{"id":64212,"date":"2018-03-09T22:52:11","date_gmt":"2018-03-09T22:52:11","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudios-de-orientacion-terapeutica-sobre-la-biologa%c2%ada-de-la-estimulacion-de-cd137-y-la-transferencia-genica-de-interleukina-15\/"},"modified":"2018-03-09T22:52:11","modified_gmt":"2018-03-09T22:52:11","slug":"estudios-de-orientacion-terapeutica-sobre-la-biologa%c2%ada-de-la-estimulacion-de-cd137-y-la-transferencia-genica-de-interleukina-15","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/inmunologia\/estudios-de-orientacion-terapeutica-sobre-la-biologa%c2%ada-de-la-estimulacion-de-cd137-y-la-transferencia-genica-de-interleukina-15\/","title":{"rendered":"Estudios de orientaci\u00f3n terap\u00e9utica sobre la biolog\u00eda de la estimulaci\u00f3n de cd137 y la transferencia g\u00e9nica de interleukina-15"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Oihana Murillo Sauca <\/strong><\/h2>\n<p>There is an ongoing explosion of knowledge in immunological sciences following the discovery of many agents that have the potential to serve as immunotherapeutic drugs. These agents include interleukin-15 (il-15) and agonistic anti-cd137 monoclonal antibodies (mabs). In animal models, both il-15 and anti-cd137 mabs have been shown to promote powerful anti-tumor responses capable of clearing established tumors, and they hold great expectations for cancer therapy in humans. However, for a rational design of treatments with these agents a fully understanding of the mechanisms behind their anti-tumor effects is needed. The driving force of the studies presented in this thesis has been the discovery of mechanistic aspects of il-15 and anti-cd137 mabs that could be suitable to improve cancer immunotherapy with these agents. In particular, our work has focused in three crucial points, to study: 1) the feasibility and mechanisms pertaining therapy of myeloma with anti-cd137 mabs, 2) the mechanisms of antigen presentation underlying immunotherapy with anti-cd137 mabs, and 3) the effects of hydrodynamically-delivered il-15 on nk cells and ikdcs, two immune cell subsets involved in tumor surveillance. This study demonstrates that anti-cd137 mab treatment shows benefit in various murine myeloma models and provides important clues on the involvement of cd8+ t lymphocytes and nk cells in the therapeutic immune response. In addition, our work provides evidence for an involvement of dc in the augmentation of anti-tumor ctl immunity by agonist anti-cd137 mabs; however the presence of dc is not absolutely required for the therapeutic effects of this anti-tumoral agent. Finally, this thesis proves the concept that liver gene transfer in mice provides a source of il-15 that thereby impacts the biology of ikdcs and nk cells up-regulating both their numbers and their cytolytic function.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudios de orientaci\u00f3n terap\u00e9utica sobre la biolog\u00eda de la estimulaci\u00f3n de cd137 y la transferencia g\u00e9nica de interleukina-15<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudios de orientaci\u00f3n terap\u00e9utica sobre la biolog\u00eda de la estimulaci\u00f3n de cd137 y la transferencia g\u00e9nica de interleukina-15 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Oihana Murillo Sauca <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/04\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ignacio Javier Melero Bermejo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Ort\u00edz de land\u00e1zuri busca <\/li>\n<li>Jos\u00e9 ignacio Mayordomo camara (vocal)<\/li>\n<li>pablo Villoslada diaz (vocal)<\/li>\n<li>Francisco Ruiz-cabello  osuna (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Oihana Murillo Sauca There is an ongoing explosion of knowledge in immunological sciences following the discovery of [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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