{"id":64304,"date":"2018-03-09T22:52:19","date_gmt":"2018-03-09T22:52:19","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudi-farmacocinetic-de-profarmacs-de-fenitoa%c2%adna\/"},"modified":"2018-03-09T22:52:19","modified_gmt":"2018-03-09T22:52:19","slug":"estudi-farmacocinetic-de-profarmacs-de-fenitoa%c2%adna","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/farmacodinamia\/estudi-farmacocinetic-de-profarmacs-de-fenitoa%c2%adna\/","title":{"rendered":"Estudi farmacocinetic de profarmacs de fenito\u00edna"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Montserrat Suriol Ferrer <\/strong><\/h2>\n<p>La fenito\u00edna se administra por v\u00eda iv en soluci\u00f3n acuosa conteniendo un porcentaje elevado de asolvente debido a su escasa solubilidad.  Asimismo, tiene un ph de n 12. Con el fin de evitar el uso de asolventes y un ph elevado se han dise\u00f1ado prof\u00e1rmacos de fenito\u00edna (r6, r71, r81, r312 y r322). Se realizan \u00abestudios in vitro\u00bb (estudio estabilidad en soluci\u00f3n acuosa a la hidr\u00f3lisis y estudio de hidr\u00f3lisis a fenito\u00edna en sangre de rata) para seleccionar el prof\u00e1rmaco id\u00f3neo para llevar a cabo un estudio farmacocin\u00e9tico del prof\u00e1rmaco seleccionado, la fenito\u00edna comercializada y un prof\u00e1rmaco de referencia tras infusi\u00f3n iv de una dosis equivalente en fenito\u00edna de 15 mg\/kg en el perro beagle (estudios \u00abin vivo\u00bb). El prof\u00e1rmaco seleccionado en los estudios \u00abin vitro\u00bb result\u00f3 ser el r322. El prof\u00e1rmaco que se toma como prof\u00e1rmaco de referencia es el r6. Se realiza un an\u00e1lisis farmacocin\u00e9tico no compartimental y compartimental. En el estudio farmacocin\u00e9tico de los prof\u00e1rmacos se realiza un ajustado simult\u00e1neo de los niveles hem\u00e1ticos de prof\u00e1rmaco, de la fenito\u00edna procedente de la hidr\u00f3lisis del prof\u00e1rmaco y de la fenito\u00edna infundida. Finalmente se concluye que la hidr\u00f3lisis del r322 \u00abin vitro\u00bb e \u00abin vivo\u00bb es m\u00e1s r\u00e1pida que la del r6, por lo que es de esperar que una soluci\u00f3n liofilizada de r322 pueda ser en humanos un buen producto para el tratamiento de la epilepsia.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudi farmacocinetic de profarmacs de fenito\u00edna<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudi farmacocinetic de profarmacs de fenito\u00edna <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Montserrat Suriol Ferrer <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/04\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Domenech Berrozpe<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Martinez lanao <\/li>\n<li>josep Queralt regue (vocal)<\/li>\n<li>marina Herraez dominguez (vocal)<\/li>\n<li>helena Colom codina (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Montserrat Suriol Ferrer La fenito\u00edna se administra por v\u00eda iv en soluci\u00f3n acuosa conteniendo un porcentaje elevado [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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