{"id":64432,"date":"2008-09-05T00:00:00","date_gmt":"2008-09-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/alcaloides-indolicos-antiparasitarios-de-especies-de-la-amazonia-peruana\/"},"modified":"2008-09-05T00:00:00","modified_gmt":"2008-09-05T00:00:00","slug":"alcaloides-indolicos-antiparasitarios-de-especies-de-la-amazonia-peruana","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/alcaloides-indolicos-antiparasitarios-de-especies-de-la-amazonia-peruana\/","title":{"rendered":"Alcaloides ind\u00f3licos antiparasitarios de especies de la amazonia peruana"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Wilfredo Ruiz Mesia <\/strong><\/h2>\n<p>En esta memoria de investigaci\u00f3n se describe el aislamiento, purificaci\u00f3n y elucidaci\u00f3n estructural de alcaloides ind\u00f3licos, aislados de cinco especies de la amazonia peruana de la familia apocinaceae, geissospernum reticulatum, aspidosperma rigidum, a. Desmanthum, a. Spruceanum y a. Schultesil, as\u00ed como los resultados obtenidos de la actividad antiparasitaria de los extractos hidroalcoh\u00f3licos y los productos puros. Se han aislado alcaloides ind\u00f3licos del tipo aspidospermatano; subtipo geissosvellina (3), subtipo tubotalwina (5) y los alcaloides geissospermidina, n-desacetil-n-butanoligeissospermidina, 10-metoxigeissospermidina y 11-metoxigeissospermidina que constituyen un nuevo subtipo de esqueleto no descrito previamente al que denominamos geissospermidina. del tipo plumerano: subtipo labersonina (3), subtipo neblinina (4), subtipo haplofitina (7), subtipo alalakina (2), subtipo quebrachamina (1). del tipo corinanteano: subtipo mitrafillina (5), subtipo akuammilina (4), subtipo normacusina b (1), subtipo vobasina (1) y subtipo aspidodasicarpina (1). el alcaloide ind\u00f3lico flavopereirina no est\u00e1 considerado dentro de esta clasificaci\u00f3n. del total de alcaloides aislados, 14 son nuevos alcaloides no descritos previamente en la bibliograf\u00eda qu\u00edmica. Adem\u00e1s, los alcaloides pagicerina, desacetilakuammilina, 10-metoxidesacetilakuammilina y 10-metoxiakuammilina se han aislado por primera vez delg\u00e9nero aspidosperma. de las pruebas de actividad biol\u00f3gica, el alcaloide caboxina b result\u00f3 activo frente a t cruzi sin citotoxicidad asociada. Los alcaloides aspidocarpina y aspidolimina, aislados de la corteza de la ra\u00edz de aspidosperma desmanthum, se mostraron muy activos frente a l. Infantum, de forma similar a 12-hidroxi-n-acetilaspidospermidina, aislado de g. Reticulatum (relacionados estructuralmente). Adem\u00e1s, tienen actividad moderada-baja frente a t. Cruzi y presentan citotoxicidad. los alcaloides tubotalwina y 11-metoxitubotalwina, aislados de corteza de la ra\u00edz, de a., Spruceanum, resultaron ser activos frente a l. Infantum, siendo tubotalvina el de mayor potencia y la presencia del grupo metoxilo en c-11 reduce esta actividad. Esta es la primera descripci\u00f3n de su actividad antiparasitaria.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alcaloides ind\u00f3licos antiparasitarios de especies de la amazonia peruana<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alcaloides ind\u00f3licos antiparasitarios de especies de la amazonia peruana <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Wilfredo Ruiz Mesia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 La laguna<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/05\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mat\u00edas Reina Artiles<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: mat\u00edas L\u00f3pez rodr\u00edguez <\/li>\n<li>Rafael Mart\u00ednez d\u00edaz (vocal)<\/li>\n<li>cirilo P\u00e9rez p\u00e9rez (vocal)<\/li>\n<li>Jes\u00fas L\u00f3pez rodilla (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Wilfredo Ruiz Mesia En esta memoria de investigaci\u00f3n se describe el aislamiento, purificaci\u00f3n y elucidaci\u00f3n estructural de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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