{"id":64456,"date":"2008-12-05T00:00:00","date_gmt":"2008-12-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modulacion-de-la-senal-de-calcio-celular-por-los-flujos-de-calcio-mitocondriales\/"},"modified":"2008-12-05T00:00:00","modified_gmt":"2008-12-05T00:00:00","slug":"modulacion-de-la-senal-de-calcio-celular-por-los-flujos-de-calcio-mitocondriales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/modulacion-de-la-senal-de-calcio-celular-por-los-flujos-de-calcio-mitocondriales\/","title":{"rendered":"Modulaci\u00f3n de la se\u00f1al de calcio celular por los flujos de calcio mitocondriales"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Vay Del Ca\u00f1o Laura <\/strong><\/h2>\n<p>Existe considerable evidencia de que las mitocondrias modulan la din\u00e1mica de calcio celular y que tienen una relaci\u00f3n priviligiada en t\u00e9rminos de homeostasis del calcio tanto con el ret\u00edculo endopl\u00e1smico como con la membrana plasm\u00e1tica. La gran capacidad y velocidad de acumulaci\u00f3n de calcio en la mitocondria le permite a este org\u00e1nulo acumular transitoriamente la mayor parte del calcio que entra en la c\u00e9lula durante la estimulaci\u00f3n celular. De esta manera, actuando como amortiguadores de los niveles de calcio, las mitocondrias son capaces de modular el tama\u00f1o de los pico de calcio citos\u00f3licos y los fen\u00f3menos asociados a estos aumentos transitorios de la concentraci\u00f3n de calcio, tales como por ejemplo la secreci\u00f3n de neurotransmisores. La posterior liberaci\u00f3n lenta del calcio acumulado por las mitocondrias genera hombros caracter\u00edsticos en los picos de calcio citos\u00f3licos y sirve tambi\u00e9n para facilitar el rellenado con calcio del ret\u00edculo endopl\u00e1smico cuando el transitorio de calcio se debe a liberaci\u00f3n desde este org\u00e1nulo. existe tambi\u00e9n evidencia estructural y funcional que sugiere que mitocondria y ret\u00edculo endopl\u00e1smico est\u00e1n estrchamente acoplados en t\u00e9rminos de homeostasis de calcio, probablementa a trav\u00e9s de interacciones estables y espec\u00edficas entre ambos organulos. De esta manera, la estrecha proximidad entre los receptores de inositol 1,4,5-trifosfato (insp3) y los uniportadores de calcio mitocondrial puede facilitar una transferencia r\u00e1pida de calcio desde el ret\u00edculo endopl\u00e1smico a la mitocondria, as\u00ed como la modulaci\u00f3n por \u00e9stas del microambiente local de calcio que rodea a los receptores de  insp3. Este mecanismo permitir\u00eda a la mitocondria controlar la liberaci\u00f3n de calcio del ret\u00edculo endopl\u00e1smico, dado que los receptores de insp3 poseen una fuerte regulaci\u00f3n feedback positiva y negativa por el nivel local de calcio en la boca de los canales. Adem\u00e1s las mitocondrias parecen tener tambi\u00e9n  interacciones espec\u00ed<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modulaci\u00f3n de la se\u00f1al de calcio celular por los flujos de calcio mitocondriales<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modulaci\u00f3n de la se\u00f1al de calcio celular por los flujos de calcio mitocondriales <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Vay Del Ca\u00f1o Laura <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Valladolid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/05\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Javier \u00e1lvarez Mart\u00edn<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel angel Valdeolmillos lopez <\/li>\n<li>luc\u00eda N\u00fa\u00f1ez llorente (vocal)<\/li>\n<li>Juan  Antonio Rosado dionisio (vocal)<\/li>\n<li>Mar\u00eda Jos\u00e9 Pozo andrada (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Vay Del Ca\u00f1o Laura Existe considerable evidencia de que las mitocondrias modulan la din\u00e1mica de calcio celular [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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