{"id":64508,"date":"2018-03-09T22:52:31","date_gmt":"2018-03-09T22:52:31","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aportacion-de-la-farmacocinetica-cla%c2%adnica-al-tratamiento-del-osteosarcoma-con-dosis-altas-de-metotrexato\/"},"modified":"2018-03-09T22:52:31","modified_gmt":"2018-03-09T22:52:31","slug":"aportacion-de-la-farmacocinetica-cla%c2%adnica-al-tratamiento-del-osteosarcoma-con-dosis-altas-de-metotrexato","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/accion-de-los-farmacos\/aportacion-de-la-farmacocinetica-cla%c2%adnica-al-tratamiento-del-osteosarcoma-con-dosis-altas-de-metotrexato\/","title":{"rendered":"Aportaci\u00f3n de la farmacocin\u00e9tica cl\u00ednica al tratamiento del osteosarcoma con dosis altas de metotrexato"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rosa Farre Riba <\/strong><\/h2>\n<p>Se ha desarrollado un modelo farmacocin\u00e9tico poblacional para metotrexato, administrado en dosis altas a ni\u00f1os diagnosticados de osteosarcoma, a partir de datos procedentes de la monitorizaci\u00f3n de 209 ciclos de metotrexato. El comportamiento farmacocin\u00e9tico se ha descrito mediante un modelo bicompartimental parametrizado en t\u00e9rminos de aclaramiento plasm\u00e1tico y vol\u00famenes de distribuci\u00f3n. El modelo de error para las variabilidades interindividual y residual ha sido proporcional en ambos casos. el peso corporal y la edad han permitido explicar parte de la variabilidad interindividual de los valores del aclaramiento plasm\u00e1tico del metotrexato (iiv: 11.9%). La \u00fanica covariable que influy\u00f3 de manera significativa sobre el volumen de distribuci\u00f3n (v1) fue el peso corporal (iiv: 8.9%). la disponibilidad de valores de concentraciones plasm\u00e1ticas de metotrexato correspondientes a distintos ciclos de tratamiento ha permitido estimar la variabilidad inter-ocasi\u00f3n (iov: 8.2%) en el aclaramiento plasm\u00e1tico del metotrexato. los estudios de validaci\u00f3n del modelo poblacional propuesto demuestran la robustez, capacidad de predicci\u00f3n y futura aplicabilidad del modelo para la monitorizaci\u00f3n de los niveles plasm\u00e1ticos de metotrexato en la pr\u00e1ctica cl\u00ednica diaria. la potencial toxicidad letal asociada a la administraci\u00f3n de altas dosis de metotrexato hace imprescindible el cumplimiento da una serie de condiciones para garantizar la correcta eliminaci\u00f3n del medicamento y el dise\u00f1o individualizado de la pauta de rescate con leucovor\u00edn. En base a los resultados obtenidos en los dos casos de intoxicaci\u00f3n por metotrexato incluidos en este proyecto, no parece que, a concentraciones pr\u00f3ximas a 300 \u00c2\u00b5mol\/l, una t\u00e9cnica invasiva como la hemoperfusi\u00f3n aporte ventajas sobre la administraci\u00f3n oral de carb\u00f3n activo para favorecer la eliminaci\u00f3n de metotrexato. Parece recomendable mantener el tratamiento con carb\u00f3n activo hasta que las concentraciones descienden por debajo de 50 \u00c2\u00b5mol\/l ya que para valores inferiores el impacto en la semivida de eliminaci\u00f3n del metotrexato no es cl\u00ednicamente relevante.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aportaci\u00f3n de la farmacocin\u00e9tica cl\u00ednica al tratamiento del osteosarcoma con dosis altas de metotrexato<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aportaci\u00f3n de la farmacocin\u00e9tica cl\u00ednica al tratamiento del osteosarcoma con dosis altas de metotrexato <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rosa Farre Riba <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/05\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Helena Colom Codina<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: antoni Diaz <\/li>\n<li>isabel Badell serra (vocal)<\/li>\n<li>azucena Aldaz pastor (vocal)<\/li>\n<li>josep Cubells riero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rosa Farre Riba Se ha desarrollado un modelo farmacocin\u00e9tico poblacional para metotrexato, administrado en dosis altas a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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