{"id":64607,"date":"2018-03-09T22:52:40","date_gmt":"2018-03-09T22:52:40","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/toxicidad-aguda-del-cadmio-y-respuesta-histopatologica-en-ratas-wistar-macho-y-hembra\/"},"modified":"2018-03-09T22:52:40","modified_gmt":"2018-03-09T22:52:40","slug":"toxicidad-aguda-del-cadmio-y-respuesta-histopatologica-en-ratas-wistar-macho-y-hembra","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/toxicologia\/toxicidad-aguda-del-cadmio-y-respuesta-histopatologica-en-ratas-wistar-macho-y-hembra\/","title":{"rendered":"Toxicidad aguda del cadmio y respuesta histopatol\u00f3gica en ratas wistar macho y hembra"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Andr\u00e9s Rueda Jim\u00e9nez <\/strong><\/h2>\n<p>Ante la preocupaci\u00f3n por los datos sobre la creciente contaminaci\u00f3n medioambiental debido a la industrializaci\u00f3n de la sociedad actual, y ante la alarma sanitaria y social por los riesgos que conlleva la exposici\u00f3n al cadmio (contaminantes medioambientales y alimentarios, puestos de trabajo, tabaco, etc.) Decidimos realizar este estudio, para determinar la posible repercusi\u00f3n a nivel hep\u00e1tico, renal y pulmonar del ci2cd administrado a elevadas dosis durante un breve per\u00edodo de tiempo. Para  ello se utilizaron 36 ratas wistar (18 hembras y 18 machos) de veinte semanas de edad, a los que se les administr\u00f3 durante 9 d\u00edas 2 g\/l de ci2cd en agua de bebida. Los sacrificios se realizaron tras este per\u00edodo de exposici\u00f3n; tras el sacrificio mediante c\u00e1mara de co2, se tomaron muestras de h\u00edgado, ri\u00f1\u00f3n y pulm\u00f3n para realizar posteriormente el an\u00e1lisi toxicol\u00f3gico, el histopatol\u00f3gico (estructural y ultraestructural). Los resultados mostraron que la concentraci\u00f3n de cadmio a nivel hep\u00e1tico era mayor que a nivel renal y mucho m\u00e1s elevado que a nivel pulmonar, tanto en hembras como en machos, sin existir diferencias significativas entre las concentraciones en las distintas v\u00edsceras entre sexos. En los animales expuestos al cadmio se apreciaron distintas lesiones seg\u00fan el \u00f3rgano afectado, as\u00ed en el h\u00edgado se observ\u00f3 un aumento de hepatocitos con esteatosis, binucleados y poliploides. Adem\u00e1s a nivel renal se apreci\u00f3 una dilataci\u00f3n de la c\u00e1psula de bowman, y glomerulonefritis mesangial, con frecuentes im\u00e1genes de degeneraci\u00f3n a nivel de los t\u00fabulos contorneados distales, la zona tubular se vio colapsada por la formaci\u00f3n de quistes en los t\u00fabulos a modo de hidronefrosis. El pulm\u00f3n se mostr\u00f3 especialmente sensible a la acci\u00f3n del metal mostrando evidentes lesiones histopatol\u00f3gicas en los animales tratados con respecto a los controles. Se observ\u00f3 hipertrofia e hiperplasia de bronquios y bronquiolos, se apreciaron nodulaciones inflamatorias y abundantes ac\u00famulos de grasa, las c\u00e9lulas ciliadas y c\u00e9lulas de clara se vieron intensamente da\u00f1adas. A la vista de nuestros resultados podemos concluir que la exposici\u00f3n subaguda a dosis elevadas de cadmio, produjeron a corto plazo lesiones muy graves a nivel de las distintas v\u00edsceras estudiadas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Toxicidad aguda del cadmio y respuesta histopatol\u00f3gica en ratas wistar macho y hembra<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Toxicidad aguda del cadmio y respuesta histopatol\u00f3gica en ratas wistar macho y hembra <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Andr\u00e9s Rueda Jim\u00e9nez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/05\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ana Mar\u00eda Molina Lopez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alfonso Blanco rodriguez <\/li>\n<li>Jos\u00e9 Mar\u00eda Vazquez auton (vocal)<\/li>\n<li>Francisco Gil cano (vocal)<\/li>\n<li>Jos\u00e9 Carlos Reymundo garcia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Andr\u00e9s Rueda Jim\u00e9nez Ante la preocupaci\u00f3n por los datos sobre la creciente contaminaci\u00f3n medioambiental debido a la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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