{"id":64612,"date":"2018-03-09T22:52:40","date_gmt":"2018-03-09T22:52:40","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-del-sistema-cannabinoide-en-la-respuesta-glial-al-deposito-del-peptido-beta-amiloide\/"},"modified":"2018-03-09T22:52:40","modified_gmt":"2018-03-09T22:52:40","slug":"papel-del-sistema-cannabinoide-en-la-respuesta-glial-al-deposito-del-peptido-beta-amiloide","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-del-sistema-cannabinoide-en-la-respuesta-glial-al-deposito-del-peptido-beta-amiloide\/","title":{"rendered":"Papel del sistema cannabinoide en la respuesta glial al dep\u00f3sito del p\u00e9ptido beta-amiloide"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Estefan\u00eda N\u00fa\u00f1ez S\u00e1nchez <\/strong><\/h2>\n<p>El descubrimiento, en los a\u00f1os 90, de los receptores del delta elevado a 9-thc, componente psicoactivo de la marihuana, revel\u00f3 la existencia de un sistema de se\u00f1alizaci\u00f3n conocido como sistema cannabinoide end\u00f3geno. \u00e9ste est\u00e1 formado por los receptores de cannabinoides cb1 y cb2, sus ligandos end\u00f3genos o endocannabinoides, y las prote\u00ednas encargadas de su s\u00edntesis e inactivaci\u00f3n. Algunos elementos del sistema cannabinoide end\u00f3geno se sobre-expresan en algunas enfermedades y en modelos animales de algunas patolog\u00edas (esquizofrenia, infarto, shock s\u00e9ptico, c\u00e1ncer, esclerosis m\u00faltiple, enfermedad de parkinson, enfermedad de huntington, obesidad, enfermedad de alzheimer). El objetivo de esta tesis es el estudio de los niveles y la distribuci\u00f3n de los distintos elementos del sistema cannabinoide end\u00f3geno en el cerebro de pacientes con la enfermedad de alzheimer y s\u00edndrome de down, as\u00ed como en los correspondientes modelos animales de ambas enfermedades. Adem\u00e1s, se ha estudiado la acci\u00f3n de los agonistas cannabinoides sobre las c\u00e9lulas gliales que se activan en respuesta a la formaci\u00f3n de los dep\u00f3sitos del p\u00e9ptido beta-amiloide.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel del sistema cannabinoide en la respuesta glial al dep\u00f3sito del p\u00e9ptido beta-amiloide<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel del sistema cannabinoide en la respuesta glial al dep\u00f3sito del p\u00e9ptido beta-amiloide <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Estefan\u00eda N\u00fa\u00f1ez S\u00e1nchez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/05\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juli\u00e1n Romero Paredes<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: javier Fernandez ruiz <\/li>\n<li>Jos\u00e9 Mart\u00ednez orgado (vocal)<\/li>\n<li>carmen Guaza rodriguez (vocal)<\/li>\n<li>leyre Mestre nieto (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Estefan\u00eda N\u00fa\u00f1ez S\u00e1nchez El descubrimiento, en los a\u00f1os 90, de los receptores del delta elevado a 9-thc, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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