{"id":64699,"date":"2018-03-09T22:52:44","date_gmt":"2018-03-09T22:52:44","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-funcional-de-psap-mtch1\/"},"modified":"2018-03-09T22:52:44","modified_gmt":"2018-03-09T22:52:44","slug":"caracterizacion-funcional-de-psap-mtch1","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica-molecular\/caracterizacion-funcional-de-psap-mtch1\/","title":{"rendered":"Caracterizaci\u00f3n funcional de psap\/mtch1"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Violeta Lamarca Gay <\/strong><\/h2>\n<p>Psap\/mtchl (presenilin 1-associated protein, mitochondrial carrier homolog 1) es una prote\u00edna mitocondrial identificadaoriginalmente como prote\u00edna que interacciona con el extremo carboxiloterminal de presenilina 1, implicada en la formaci\u00f3n delp\u00e9ptido amiloide en la enfermedad de alzheimer. La sobreexpresi\u00f3n de psap\/mtchl induce apoptosis en las c\u00e9lulas, medianteliberaci\u00f3n de citocromo c de la mitocondria independiente de la acci\u00f3n de las caspasas. En el presente estudio, se trat\u00f3 decaracterizar funcionalmente esta prote\u00edna, para lo cual se establecieron cuatro objetivos generales: identificar qu\u00e9 dominios dentro dela prote\u00edna son los responsables de su importaci\u00f3n a la mitocondria, as\u00ed como de su capacidad para inducir apoptosis; determinar cu\u00e1les la localizaci\u00f3n submitocondrial de la prote\u00edna; identificar prote\u00ednas que interaccionan con ella mediante el sistemas de dosh\u00edbridos en levaduras; y tratar de dilucidar la v\u00eda por la cual la prote\u00edna induce apoptosis al ser sobreexpresada.Seg\u00fan los estudios llevados a cabo, se lleg\u00f3 a la conclusi\u00f3n de que la prote\u00edna tiene dos isoformas generadas por splicing alternativoque se localizan en la membrana externa de la mitocondria, y son prote\u00ednas integrales de ella. En la regi\u00f3n aminoterminal de laprote\u00edna se identificaron dos dominios independientes capaces de inducir apoptosis por s\u00ed mismos al ser sobreexpresados y dirigidosa la membrana externa de la mitocondria. Adem\u00e1s, la apoptosis inducida por psap\/mtchl es independiente de la acci\u00f3n de lasprote\u00ednas proapopt\u00f3ticas de la familia de bc12 bax y bak. Los resultados sugieren que psap\/mtchl induce apoptosis a trav\u00e9s delporo de transici\u00f3n de permeabilidad.Por otro lado, el sistema de dos h\u00edbridos levado a cabo -y la confirmaci\u00f3n posterior de las interacciones identificadas por la t\u00e9cnicade pull down o arrastre- muestra que psap\/mtchl interacciona, al menos in vitro, con cd22 (cluster of differentiation 22), prote\u00ednalocalizada en la membr<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n funcional de psap\/mtch1<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n funcional de psap\/mtch1 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Violeta Lamarca Gay <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/05\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Carrodeguas Villar Jos\u00e9 Alberto<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: javier Naval iraberri <\/li>\n<li>joaqu\u00edn Jord\u00e1n bueso (vocal)<\/li>\n<li> Osta pinzolas Mar\u00eda rosario (vocal)<\/li>\n<li>v\u00edctor Yuste mateos (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Violeta Lamarca Gay Psap\/mtchl (presenilin 1-associated protein, mitochondrial carrier homolog 1) es una prote\u00edna mitocondrial identificadaoriginalmente como [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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