{"id":64724,"date":"2018-03-09T22:52:48","date_gmt":"2018-03-09T22:52:48","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudios-estructura-funcion-de-un-surfactante-pulmonar-sintetico-basado-en-el-peptido-antipatico-kl4-y-analisis-de-su-eficacia-terapeutica-en-trasplante-de-pulmon-experimental\/"},"modified":"2018-03-09T22:52:48","modified_gmt":"2018-03-09T22:52:48","slug":"estudios-estructura-funcion-de-un-surfactante-pulmonar-sintetico-basado-en-el-peptido-antipatico-kl4-y-analisis-de-su-eficacia-terapeutica-en-trasplante-de-pulmon-experimental","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica\/estudios-estructura-funcion-de-un-surfactante-pulmonar-sintetico-basado-en-el-peptido-antipatico-kl4-y-analisis-de-su-eficacia-terapeutica-en-trasplante-de-pulmon-experimental\/","title":{"rendered":"Estudios estructura-funci\u00f3n de un surfactante pulmonar sint\u00e9tico basado en el p\u00e9ptido antip\u00e1tico kl4 y an\u00e1lisis de su eficacia terap\u00e9utica en trasplante de pulm\u00f3n experimental"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alejandra S\u00e1enz Mart\u00ednez <\/strong><\/h2>\n<p>Esta tesis analiza las relaciones estructura-funci\u00f3n del surfactante pulmonar. Para ello se ha empleado un surfactante natural de origen animal y distintos surfactantes sint\u00e9ticos basados en el p\u00e9ptido antip\u00e1tico kl4, as\u00ed como un abordaje experimental multidisciplinar, utilizando t\u00e9cnicas biof\u00edsicas, bioqu\u00edmicas e inmunol\u00f3gicas (cap\u00edtulos i, ii y iii) y un modelo animal de transplante de pulm\u00f3n para evaluar el efecto terap\u00e9utico de un surfactante sint\u00e9tico basado en kl$ (c\u00e1p\u00edtulo iv). A partir de distintas situaciones experimentales o patol\u00f3gicas que dan lugar a la inhibici\u00f3n de la actividad biof\u00edsica del surfactante (cap\u00edtulos i, ii y iii) se extrae la conclusi\u00f3n de que la coexistencia de fases l\u00edquido ordenada\/l\u00edquido desordenada en surfactantes naturales y s\u00f3lido\/flu\u00eddo en sint\u00e9ticos, es fundamental para el correcto funcionamiento del surfactante pulmonar. Este hallazgo es de gran inter\u00e9s, no solo porque aporta m\u00e1s conocimiento respecto a las caracter\u00edsticas estructurales de las membranas del surfactante necesarias para su funci\u00f3n, sino porque facilitar\u00e1 la formulaci\u00f3n de nuevos surfactantes sint\u00e9ticos. Por otra parte, los estudios de interacci\u00f3n de las membranas del surfactante pulmonar con la apolipoprote\u00edna a de dicho complejo (sp-a) (cap\u00edtulo ii) y de su papel en la protecci\u00f3n del surfactante frente a la inactivaci\u00f3n por la prote\u00edna reactiva c del plasma (cap\u00edtulo iii) y frente al da\u00f1o tras la isquemia-reperfusi\u00f3n en transplante de pulm\u00f3n (cap\u00edtulo iv), abren nuevas perspectivas y apoyan la utilizaci\u00f3n terap\u00e9utica de formas recombinantes de sp-a, en la composici\u00f3n de surfactantes sint\u00e9ticos o naturales.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudios estructura-funci\u00f3n de un surfactante pulmonar sint\u00e9tico basado en el p\u00e9ptido antip\u00e1tico kl4 y an\u00e1lisis de su eficacia terap\u00e9utica en trasplante de pulm\u00f3n experimental<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudios estructura-funci\u00f3n de un surfactante pulmonar sint\u00e9tico basado en el p\u00e9ptido antip\u00e1tico kl4 y an\u00e1lisis de su eficacia terap\u00e9utica en trasplante de pulm\u00f3n experimental <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alejandra S\u00e1enz Mart\u00ednez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/05\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Cristina Casals Carro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Perez gil <\/li>\n<li>jordi Hern\u00e1ndez borrell (vocal)<\/li>\n<li>Luis Alberto Bagatolli (vocal)<\/li>\n<li>alicia Alonso izquierdo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alejandra S\u00e1enz Mart\u00ednez Esta tesis analiza las relaciones estructura-funci\u00f3n del surfactante pulmonar. Para ello se ha empleado [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[36483,160],"tags":[142800,13242,6747,25839,102145,142801],"class_list":["post-64724","post","type-post","status-publish","format-standard","hentry","category-biologia-molecular","category-bioquimica","tag-alejandra-saenz-Martinez","tag-alicia-alonso-izquierdo","tag-cristina-casals-carro","tag-jesus-perez-gil","tag-jordi-hernandez-borrell","tag-luis-alberto-bagatolli"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/64724","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=64724"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/64724\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=64724"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=64724"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=64724"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}