{"id":64948,"date":"2008-04-06T00:00:00","date_gmt":"2008-04-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-protectores-de-la-grelina-y-el-ghrp-6-frente-a-los-danos-hipotalamicos-inducidos-por-la-excitotoxicidad-y-la-diabetes-mellitus\/"},"modified":"2008-04-06T00:00:00","modified_gmt":"2008-04-06T00:00:00","slug":"efectos-protectores-de-la-grelina-y-el-ghrp-6-frente-a-los-danos-hipotalamicos-inducidos-por-la-excitotoxicidad-y-la-diabetes-mellitus","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/patologia\/efectos-protectores-de-la-grelina-y-el-ghrp-6-frente-a-los-danos-hipotalamicos-inducidos-por-la-excitotoxicidad-y-la-diabetes-mellitus\/","title":{"rendered":"Efectos protectores de la grelina y el ghrp-6 frente a los da\u00f1os hipotal\u00e1micos inducidos por la excitotoxicidad y la diabetes mellitus"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Arancha Delgado Rub\u00edn De C\u00e9lix <\/strong><\/h2>\n<p>En esta tesis doctoral se ha investigado exhaustivamente si la grelina y los secretagogos de gh pueden proteger frente a los da\u00f1os excitot\u00f3xicos inducidos por el glutamato monos\u00f3dico en el hipot\u00e1lamo, as\u00ed como frente a aqu\u00e9llos observados en los animales con una diabetes mellitus experimental tipo 1, mejorando la situaci\u00f3n metab\u00f3lica de los individuos afectados. Los estudios se han efectuado en ratas wistar macho adultas, a las que se inyect\u00f3 glutamato monos\u00f3dico, al objeto de generar el modelo de excitotoxicidad, o bien estreptozotocina, para inducir diabetes mellitus, as\u00ed como grelina y ghrp-6 de modo cr\u00f3nico para estudiar sus efectos sobre los daos hipotal\u00e1micos provocados. Estos estudios han permitido demostrar que el ghrp-6, un secretagogo de gh an\u00e1logo a la grelina, promueve la supervivencia de las neuronas hipotal\u00e1micas mediante la promoci\u00f3n de la v\u00eda intracelular de akt, y la inhibici\u00f3n de las v\u00edas apopt\u00f3ticas inducidad por la excitotoxicidad. Adem\u00e1s, es capaz de promover una reorganizaci\u00f3n sin\u00e1ptica en el hipot\u00e1lamo, posiblemente favoreciendo la mejora metab\u00f3lica de los individuos afectados. Por otro lado, hemos podido demostrar que tanto la grelina como el ghrp-6 revierten la muerte de los astrocitos hipotal\u00e1micos inducida por la diabetes mellitus tipo 1 de larga evoluci\u00f3n sin control metab\u00f3lico, induciendo, asimismo, cambios sin\u00e1pticos en dicha regi\u00f3n. Por \u00faltimo, mediante estudios en un modelo in vitro se ha demostrado que los efectos del ghrp-6 sobre la supervivencia neuronal son independientes de su capacidad para inducir la expresi\u00f3n de igf-i, conocido factor neuroprotector.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos protectores de la grelina y el ghrp-6 frente a los da\u00f1os hipotal\u00e1micos inducidos por la excitotoxicidad y la diabetes mellitus<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos protectores de la grelina y el ghrp-6 frente a los da\u00f1os hipotal\u00e1micos inducidos por la excitotoxicidad y la diabetes mellitus <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Arancha Delgado Rub\u00edn De C\u00e9lix <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/06\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Laura Mar\u00eda Frago Fern\u00e1dez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jos\u00e9 Quero jim\u00e9nez <\/li>\n<li>isabel Varela nieto (vocal)<\/li>\n<li>Luis Miguel Garc\u00eda segura (vocal)<\/li>\n<li>i\u00f1igo Azcoitia elias (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Arancha Delgado Rub\u00edn De C\u00e9lix En esta tesis doctoral se ha investigado exhaustivamente si la grelina y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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