{"id":6500,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/caracterizacion-estructural-y-funcional-de-la-proteina-s-del-bhsag-mutantes-de-cisteina-y-peptido-de-fusion\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"caracterizacion-estructural-y-funcional-de-la-proteina-s-del-bhsag-mutantes-de-cisteina-y-peptido-de-fusion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/caracterizacion-estructural-y-funcional-de-la-proteina-s-del-bhsag-mutantes-de-cisteina-y-peptido-de-fusion\/","title":{"rendered":"Caracterizacion estructural y funcional de la proteina s del bhsag: mutantes de cisteina y peptido de fusion"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Rodriguez Crespo Jos\u00e9 Ignacio <\/strong><\/h2>\n<p>En la presente memoria de investigacion se ha llevado a cabo la caracterizacion tanto estructural como antigenica de la proteina s del antigeno de superficie del virus b de la hepatitis clonada y expresada en celulas cho asi como de cuatro mutantes sencillos de cisteina por serina y dos mutantes dobles. Asimismo, se ha llevado a cabo la caracterizacion de las propiedades de interaccion con lipidos de un peptido sintetico correspondiente al extremo n-terminal de la proteina s del hbsag que presenta homolog\u00edas de secuencia con peptidos de fusion de la familia de los retrovirus y de los paramyxovirus.  dicho peptido ha demostrado ser capaz de interaccionar con lipidos promoviendo procesos de hemolisis agregacion, mezcla de lipidos y ruptura vesicular.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizacion estructural y funcional de la proteina s del bhsag: mutantes de cisteina y peptido de fusion<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizacion estructural y funcional de la proteina s del bhsag: mutantes de cisteina y peptido de fusion <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Rodriguez Crespo Jos\u00e9 Ignacio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Gavilanes Franco<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Gregorio Gavilanes Franco <\/li>\n<li>Jos\u00e9 Manuel Gonzalez Ros (vocal)<\/li>\n<li> Ferragot Rodriguez Jos\u00e9 Antonio (vocal)<\/li>\n<li> Laynez Vallejo Jos\u00e9 Luis (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rodriguez Crespo Jos\u00e9 Ignacio En la presente memoria de investigacion se ha llevado a cabo la caracterizacion [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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