{"id":65060,"date":"2008-09-06T00:00:00","date_gmt":"2008-09-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-incorporacion-migracion-y-diferenciacion-de-celulas-madre-humanas-procedentes-de-cordon-umbilical-implantadas-en-corazones-de-embrion-de-pollo\/"},"modified":"2008-09-06T00:00:00","modified_gmt":"2008-09-06T00:00:00","slug":"estudio-de-la-incorporacion-migracion-y-diferenciacion-de-celulas-madre-humanas-procedentes-de-cordon-umbilical-implantadas-en-corazones-de-embrion-de-pollo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/biologia-humana\/estudio-de-la-incorporacion-migracion-y-diferenciacion-de-celulas-madre-humanas-procedentes-de-cordon-umbilical-implantadas-en-corazones-de-embrion-de-pollo\/","title":{"rendered":"Estudio de la incorporaci\u00f3n, migraci\u00f3n y diferenciaci\u00f3n de c\u00e9lulas madre humanas procedentes de cord\u00f3n umbilical implantadas en corazones de embri\u00f3n de pollo"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Nuria Torre Perez <\/strong><\/h2>\n<p>En este trabajo hemos analizado la migraci\u00f3n y la diferenciaci\u00f3n de c\u00e9lulas madre humanas derivadas de sangre de cord\u00f3n umbilical (schucb) ijertadas en corazones de embriones de pollo normales y lesionados. Observamos que las c\u00e9lulas madre no son rechazadas por el coraz\u00f3n hu\u00e9sped y que en los corazones normales, las c\u00e9lulas madre migran por las pardes card\u00edacas mostrando preferencia por los tejidos valvulares,  mientras que en los corazones lesionados las c\u00e9lulas son atra\u00eddas fuertemente por el tejido da\u00f1ado. Caracterizamos las c\u00e9lulas madre antes de su injerto y observamos que expresan tanto genes indicadores del estod de indiferenciaci\u00f3n (c-kit y cd34) como genes precardiog\u00e9nicos (nkx2.5, gata4, mef2 y serca2a) . A los tres d\u00edas posteriores a la inyecci\u00f3n de las c\u00e9lulas, \u00e9stas muestran una morfolog\u00eda caracter\u00edstica del m\u00fasculo card\u00edaco y detectamos la presencia de trascritos humanos para genes  de diferenciaci\u00f3n cardiomioc\u00edtica (mlcsa y mhcb) a los tres d\u00edas posteriores a la inyecci\u00f3n, tanto en corazones normales como lesionados. Sin embargo, hemos encontrado una diferenciaci\u00f3n de las c\u00e9lulas, tanto ex\u00f3genas como end\u00f3genas, hacia tejido endotelial en los corazones lesioados, resultados no observados en los corazones normales. Esto indica la importancia de las condiciones fisiol\u00f3gicas del propio tejido para dirigir la diferenciaci\u00f3n de las c\u00e9lulas madre ex\u00f3genas. Adicionalmen te, hemos identificado mol\u00e9culas que participan en la migraci\u00f3n de las c\u00e9lulas madre, como sdf-1, mcp-1 o wnt5a.                             todos estos hallazgos respaldan la hip\u00f3tesis de que el coraz\u00f3n embrionario de pollo es un buen modelo para la experimentaci\u00f3n en terapias con c\u00e9lulas madre.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la incorporaci\u00f3n, migraci\u00f3n y diferenciaci\u00f3n de c\u00e9lulas madre humanas procedentes de cord\u00f3n umbilical implantadas en corazones de embri\u00f3n de pollo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la incorporaci\u00f3n, migraci\u00f3n y diferenciaci\u00f3n de c\u00e9lulas madre humanas procedentes de cord\u00f3n umbilical implantadas en corazones de embri\u00f3n de pollo <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Nuria Torre Perez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Cantabria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/06\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Mario Hurle Gonzalez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Antonio Garcia-porrero perez <\/li>\n<li>Ana M\u00aa de los angeles Sanchez garcia (vocal)<\/li>\n<li>Jos\u00e9 Carlos Rodriguez rey (vocal)<\/li>\n<li>damian Sanchez quintana (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Nuria Torre Perez En este trabajo hemos analizado la migraci\u00f3n y la diferenciaci\u00f3n de c\u00e9lulas madre humanas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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