{"id":65098,"date":"2008-10-06T00:00:00","date_gmt":"2008-10-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/evaluacion-de-diferentes-estrategias-terapeuticas-en-un-modelo-experimental-de-sindrome-de-aspiracion-meconial\/"},"modified":"2008-10-06T00:00:00","modified_gmt":"2008-10-06T00:00:00","slug":"evaluacion-de-diferentes-estrategias-terapeuticas-en-un-modelo-experimental-de-sindrome-de-aspiracion-meconial","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/patologia-experimental\/evaluacion-de-diferentes-estrategias-terapeuticas-en-un-modelo-experimental-de-sindrome-de-aspiracion-meconial\/","title":{"rendered":"Evaluacion de diferentes estrategias terapeuticas en un modelo experimental de sindrome de aspiracion meconial"},"content":{"rendered":"<h2>Tesis doctoral de <strong> M\u00aa Carmen Rey Santano <\/strong><\/h2>\n<p>La fisiopatolog\u00eda del s\u00edndrome de aspiraci\u00f3n meconial (sam) es muy compleja. Los hallazgos fisiopatol\u00f3gicos se caracterizan por un inadecuado intercambio gaseoso, hipertensi\u00f3n pulmonar y fallo ventilatorio. En esta patolog\u00eda influyen gran cantidad de factores como son: la obstrucci\u00f3n de la v\u00eda a\u00e9rea por el meconio, la inflamaci\u00f3n, la toxicidad directa derivada de los componentes propios del meconio y la alteraci\u00f3n de la vasoreactividad pulmonar, as\u00ed como el edema generado. En los reci\u00e9n nacidos a t\u00e9rmino, poblaci\u00f3n susceptible de sufrir sam, el sistema del surfactante pulmonar est\u00e1 completamente maduro con una cantidad normal de surfactante. En esta patolog\u00eda se produce una alteraci\u00f3n del sistema del surfactante pulmonar causado tanto por la inactivaci\u00f3n, como por la disminuci\u00f3n de los niveles de fosfol\u00edpidos y de prote\u00ednas asociadas al surfactante. Estos fen\u00f3menos conducen a una disminuci\u00f3n de las propiedades el\u00e1sticas del pulm\u00f3n dificultando el intercambio gaseoso. La instilaci\u00f3n de meconio humano en modelos experimentales produce una sintomatolog\u00eda que se asemeja al proceso fisiopatol\u00f3gico presente en reci\u00e9n nacidos diagnosticados de sam. La evaluaci\u00f3n de diferentes terapias como la amnioinfusi\u00f3n, la ventilaci\u00f3n de alta frecuencia, el surfactante natural, etc., No han logrado demostrar unos buenos resultados. Por ello, se est\u00e1n valorando otras alternativas terap\u00e9uticas, como es el empleo de otros agentes tensoactivos que no sean inhibidos por la acci\u00f3n del meconio como los  surfactantes sint\u00e9ticos o los perfluorocarbonos. Los compuestos perfluorocarbonados poseen unas propiedades f\u00edsico-qu\u00edmicas ideales, ya que disuelven grandes cantidades de gases respiratorios y mejoran las propiedades el\u00e1sticas del pulm\u00f3n. Estos compuestos sustituyen la interfase alveolar aire-l\u00edquido por otra l\u00edquido-l\u00edquido, reduciendo as\u00ed la tensi\u00f3n superficial a nivel alveolar generada por la inactivaci\u00f3n del surfactante pulmonar end\u00f3geno.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Evaluacion de diferentes estrategias terapeuticas en un modelo experimental de sindrome de aspiracion meconial<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Evaluacion de diferentes estrategias terapeuticas en un modelo experimental de sindrome de aspiracion meconial <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M\u00aa Carmen Rey Santano <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/06\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Elena Gastiasoro Cuesta<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan Rodriguez soriano <\/li>\n<li>Jos\u00e9 Antonio Martinez orgado (vocal)<\/li>\n<li>Miguel Garcia fuentes (vocal)<\/li>\n<li>josep Figueras aloy (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M\u00aa Carmen Rey Santano La fisiopatolog\u00eda del s\u00edndrome de aspiraci\u00f3n meconial (sam) es muy compleja. Los hallazgos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17971,12909,1323],"tags":[126757,105254,163,26318,10555,143599],"class_list":["post-65098","post","type-post","status-publish","format-standard","hentry","category-fisiologia-de-la-respiracion","category-pais-vasco-euskal-herriko-unibertsitatea","category-patologia-experimental","tag-elena-gastiasoro-cuesta","tag-jose-antonio-Martinez-orgado","tag-josep-figueras-aloy","tag-juan-rodriguez-soriano","tag-miguel-garcia-fuentes","tag-ma-carmen-rey-santano"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/65098","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=65098"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/65098\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=65098"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=65098"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=65098"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}