{"id":65137,"date":"2008-11-06T00:00:00","date_gmt":"2008-11-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/receptores-implicados-en-el-efecto-neurotrofico-del-acido-oleico-durante-el-desarrollo-del-snc\/"},"modified":"2008-11-06T00:00:00","modified_gmt":"2008-11-06T00:00:00","slug":"receptores-implicados-en-el-efecto-neurotrofico-del-acido-oleico-durante-el-desarrollo-del-snc","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica-molecular\/receptores-implicados-en-el-efecto-neurotrofico-del-acido-oleico-durante-el-desarrollo-del-snc\/","title":{"rendered":"Receptores implicados en el efecto neurotr\u00f3fico del \u00e1cido oleico durante el desarrollo del snc"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Andr\u00e9 F\u00e1bio Bento Abreu <\/strong><\/h2>\n<p>La existencia de un receptor espec\u00edfico para la alb\u00famina en el cerebro, responsable de la elevada concentraci\u00f3n de la alb\u00famina en el cerebro durante los primeros d\u00edas de vida posnatal y cuya expresi\u00f3n se encuentre regulada durante el desarrollo, se ha postulado durante d\u00e9cadas. Sin embargo, se desconoc\u00eda todav\u00eda la naturaleza del receptor, as\u00ed como el tipo de endocitosis empleada para la internalizaci\u00f3n de la alb\u00famina en los astrocitos. En este trabajo, hemos observado que la megalina, la caveolina-1 y la caveolina-2, pero no la clatrina, colocalizan con la alb\u00famina en la membrana plasm\u00e1tica. Adem\u00e1s, dado que el silenciamiento de la megalina, de la caveolina-1 y de la caveolina-2, pero no el de la clatrina, reducen la capacidad de la alb\u00famina para unirse a la membrana e internalizarse, se puede concluir que la megalina es el receptor de la alb\u00famina en los astrocitos y que la endocitosis de la alb\u00famina en los astrocitos est\u00e1 mediada por caveolas y no por ves\u00edculas recubiertas de clatrina.  la internalizaci\u00f3n de la alb\u00famina en los astrocitos promueve la sintesis del factor neurotr\u00f3fico \u00e1cido oleico, que induce la diferenciaci\u00f3n neuronal (aumento de las neuritas y aumento de las prote\u00ednas marcadoras de diferenciaci\u00f3n axonal, gap-43, y dendr\u00edtico, map-2). Dado que el \u00e1cido oleico es un ligando y activador de los ppars, hemos investigado el papel de estos como receptores para el \u00e1cido oleico en neuronas. Nuestros resultados muestran que, pese a que las neuronas en cultivo primario expresen las tres isoformas de los ppars (alfa, beta y gamma), solo la activaci\u00f3n por ligandos espec\u00edficos del pparalfa, y no del pparbeta y del ppargamma, induce la diferenciaci\u00f3n neuronal. Adem\u00e1s, el \u00e1cido oleico activa el pparalfa en las neuronas en cultivo. Finalmente, el silenciamiento del pparalfa previene la diferenciaci\u00f3n neuronal inducida por el \u00e1cido oleico, lo que sugiere que el pparalfa es el receptor del \u00e1cido oleico para su efecto neurotr\u00f3fico en la diferenciaci\u00f3n neuronal.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Receptores implicados en el efecto neurotr\u00f3fico del \u00e1cido oleico durante el desarrollo del snc<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Receptores implicados en el efecto neurotr\u00f3fico del \u00e1cido oleico durante el desarrollo del snc <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Andr\u00e9 F\u00e1bio Bento Abreu <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/06\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Mar\u00eda Medina Jimenez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: federico Mayor zaragoza <\/li>\n<li>Ana Sastre gallego (vocal)<\/li>\n<li>Emilio Herrera castillon (vocal)<\/li>\n<li>Fernando De castro soubriet (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Andr\u00e9 F\u00e1bio Bento Abreu La existencia de un receptor espec\u00edfico para la alb\u00famina en el cerebro, responsable [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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