{"id":65202,"date":"2018-03-09T22:53:17","date_gmt":"2018-03-09T22:53:17","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/inactivacio-del-mecanisme-de-vigilancia-de-la-fase-s-estudi-de-les-fosfatases-responsables-de-la-desfosforilacio-de-la-quinasa-efectora-central-rad53\/"},"modified":"2018-03-09T22:53:17","modified_gmt":"2018-03-09T22:53:17","slug":"inactivacio-del-mecanisme-de-vigilancia-de-la-fase-s-estudi-de-les-fosfatases-responsables-de-la-desfosforilacio-de-la-quinasa-efectora-central-rad53","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/inactivacio-del-mecanisme-de-vigilancia-de-la-fase-s-estudi-de-les-fosfatases-responsables-de-la-desfosforilacio-de-la-quinasa-efectora-central-rad53\/","title":{"rendered":"Inactivacio del mecanisme de vigilancia de la fase s. estudi de les fosfatases responsables de la desfosforilacio de la quinasa efectora central rad53"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Anna Travesa Centrich <\/strong><\/h2>\n<p>Los mecanismos de vigilancia o checkpoints son cruciales para mantener la estabilidad gen\u00f3mica de la c\u00e9lula. En concreto, el checkpoint de la fase s detecta da\u00f1o al dna o estr\u00e9s replicativo y genera una respuesta global en la c\u00e9lula que permite parar el ciclo celular para permitir a la c\u00e9lula reparar el da\u00f1o celular. Errores en la inactivaci\u00f3n del checkpoint conllevan la muerte reproductiva y la lisis celular. en este trabajo de tesis, se ha estudiado el proceso de inactivaci\u00f3n de la quinasa efectora central de s, cerevisiae, rad53. Rad53 es una quinasa que se activa por hiperfosforilaci\u00f3n en trans, y su inactivaci\u00f3n correlaciona con su desfosforilaci\u00f3n, de manera que una o m\u00e1s fosfatasas son responsables de esta inactivaci\u00f3n. en esta tesis, se ha sugerido un modelo en el que varias fosfatasas son las responsables de la inactivaci\u00f3n de rad53 dependiendo del tipo de da\u00f1o que haya activado rad53.Ptc2 y ptc3 han sido involucradas previamente en la inactivaci\u00f3n de rad53 despu\u00e9s de una rotura de doble hebra del dna. En este trabajo, hemos mostrado que ptc2 y ptc3 son necesarias para la inactivaci\u00f3n de rad53 despu\u00e9s de da\u00f1o por mutilaci\u00f3n del dna. En el caso de estr\u00e9s replicativo, nuestro trabajo sugiere la existencia de redundancia entre actividades fosfatasas capaces de inactivar rad53, ya que se ha llevado a cabo un estudio sistem\u00e1tico de la mayor\u00eda de subunidades fosfatasas existentes en la levadura de gemaci\u00f3n, y ninguna es necesaria por s\u00ed sola para la desfosforilaci\u00f3n de rad53 despu\u00e9s de estr\u00e9s replicativo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Inactivacio del mecanisme de vigilancia de la fase s. estudi de les fosfatases responsables de la desfosforilacio de la quinasa efectora central rad53<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Inactivacio del mecanisme de vigilancia de la fase s. estudi de les fosfatases responsables de la desfosforilacio de la quinasa efectora central rad53 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Anna Travesa Centrich <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/06\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>David Garc\u00eda Quintana<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: joaqu\u00edn Ari\u00f1o carmona <\/li>\n<li>benjam\u00ed Pi\u00f1a cap\u00f3 (vocal)<\/li>\n<li>mireia Du\u00f1ach masJuan (vocal)<\/li>\n<li>Mar\u00eda  isabel Geli fernandez-pe\u00f1aflor (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Anna Travesa Centrich Los mecanismos de vigilancia o checkpoints son cruciales para mantener la estabilidad gen\u00f3mica de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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