{"id":65217,"date":"2018-03-09T22:53:17","date_gmt":"2018-03-09T22:53:17","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/integration-of-shh-and-wnt-patways-controls-morphogenesis-of-the-cns-la-integracion-de-las-senales-shh-y-wnt-controlan-la-morgogenesis-del-snc\/"},"modified":"2018-03-09T22:53:17","modified_gmt":"2018-03-09T22:53:17","slug":"integration-of-shh-and-wnt-patways-controls-morphogenesis-of-the-cns-la-integracion-de-las-senales-shh-y-wnt-controlan-la-morgogenesis-del-snc","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/barcelona\/integration-of-shh-and-wnt-patways-controls-morphogenesis-of-the-cns-la-integracion-de-las-senales-shh-y-wnt-controlan-la-morgogenesis-del-snc\/","title":{"rendered":"Integration of shh and wnt patways controls morphogenesis of the cns (la integracion de las se\u00f1ales shh y wnt controlan la morgog\u00e9nesis del snc)"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Roberto Alvarez Medina <\/strong><\/h2>\n<p>La formaci\u00f3n del patr\u00f3n dorsoventral del sistema nervioso central en vertebrados est\u00e1 controlada por la acci\u00f3n de se\u00f1ales morfogen\u00e9ticas. Estas se\u00f1ales son secretadas por centros de se\u00f1alizaci\u00f3n situados en el extremo dorsal, ectodermo y placa del techo, y ventral, notocorda y placa del suelo, del tubo neural. La v\u00eda de se\u00f1alizaci\u00f3n de shh\/gli juega un papel principal in el establecimiento temprano de la regi\u00f3n ventral del tubo neural. Sin embargo, los mecanismos moleculares que restringen la expresi\u00f3n de los genes responsables de establecer este patr\u00f3n a un dominio concreto no son del todo conocidos. En este trabajo mostramos que las se\u00f1ales morphogen\u00e9ticas wnt1 y wnt3a, activando la v\u00eda de se\u00f1alizaci\u00f3n can\u00f3nica medida por \u00edY-catenina\/tcf, regulan la expresi\u00f3n de genes dorsales y reprimen el programa ventral, mediante un mecanismo que depende de la actividad gli. Adem\u00e1s, mostramos que la expresi\u00f3n de gli3 humano revela que contienen sitios de uni\u00f3n consenso para los factores tcf\/lef-1 activos. Esto indica que la expresi\u00f3n dorsal de gli3 est\u00e1 controlada directamente por la actividad de la v\u00eda can\u00f3nica de wnt. A su vez, gli3, actuando como un represor transcripcional, restringe la actividad del gradiente ventral shh\/gli para establecer el patr\u00f3n dorsoventral del tubo neural correctamente.  las v\u00edas can\u00f3nicas de se\u00f1alizaci\u00f3n celular de wnt y hedgehog regulan la proliferaci\u00f3n celular en varios contextos de forma conjunta, sin embargo, posibles interacciones de estas v\u00edas de se\u00f1alizaci\u00f3n en el control del ciclo celular no han sido estudiadas. Durante el desarrollo del sistema nervioso de vertebrados, aunque las prote\u00ednas shh y wnts se expresan en extremos dorso-ventralmente opuestos del tubo neural, varios trabajos demuestran que es necesaria la integraci\u00f3n de ambas v\u00edas de se\u00f1alizaci\u00f3n para controlar la duraci\u00f3n de la fase g1 del ciclo celular. Adem\u00e1s, mostramos el requerimiento de la actividad hedgehog para la regulaci\u00f3n medida por wnt de la expresi\u00f3n del activador de ciclo celular ciclina d1, componente clave para la progresi\u00f3n a trav\u00e9s de g1. Aunque la actividad de la v\u00eda can\u00f3nica de wnt se limita al control de la transici\u00f3n g1\/s, adicionalmente, la actividad hedgehog regula la duraci\u00f3n de la fase g2 mediante la regulaci\u00f3n de las ciclinas de fase g2 ciclina a2 y ciclinas b2\/b3. En conjunto, estos resultados proponen un papel fundamental en el control del crecimiento para la actividad shh\/gli como reguladora de las fases g1 y g2 del ciclo celular y adem\u00e1s como reguladora por encima de l actividad can\u00f3nica de wnt.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Integration of shh and wnt patways controls morphogenesis of the cns (la integracion de las se\u00f1ales shh y wnt controlan la morgog\u00e9nesis del snc)<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Integration of shh and wnt patways controls morphogenesis of the cns (la integracion de las se\u00f1ales shh y wnt controlan la morgog\u00e9nesis del snc) <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Roberto Alvarez Medina <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/06\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Elisa Mart\u00ed Gorostiza<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: emilio Salo boix <\/li>\n<li>Elena Sancho suils (vocal)<\/li>\n<li>mart\u00ed Aldea malo (vocal)<\/li>\n<li>Jos\u00e9 Luis Gomez skarmeta (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Roberto Alvarez Medina La formaci\u00f3n del patr\u00f3n dorsoventral del sistema nervioso central en vertebrados est\u00e1 controlada [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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