{"id":65247,"date":"2018-03-09T22:53:21","date_gmt":"2018-03-09T22:53:21","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-del-tratamiento-preoperatorio-con-estatinas-sobre-la-respuesta-inflamatoria-sistemica-y-el-dano-miocardico-tras-intervenciones-carda%c2%adacas-con-circulacion-extracorporea\/"},"modified":"2018-03-09T22:53:21","modified_gmt":"2018-03-09T22:53:21","slug":"efectos-del-tratamiento-preoperatorio-con-estatinas-sobre-la-respuesta-inflamatoria-sistemica-y-el-dano-miocardico-tras-intervenciones-carda%c2%adacas-con-circulacion-extracorporea","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cardiologia\/efectos-del-tratamiento-preoperatorio-con-estatinas-sobre-la-respuesta-inflamatoria-sistemica-y-el-dano-miocardico-tras-intervenciones-carda%c2%adacas-con-circulacion-extracorporea\/","title":{"rendered":"Efectos del tratamiento preoperatorio con estatinas sobre la respuesta inflamatoria sist\u00e9mica y el da\u00f1o mioc\u00e1rdico tras intervenciones card\u00edacas con circulaci\u00f3n extracorp\u00f3rea."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Manuel Martinez Comendador <\/strong><\/h2>\n<p>Objetivos: determinar si el tratamiento preoperatorio con estatinas se asocia a una disminuci\u00f3n de la respuesta inflamatoria sist\u00e9mica (ris) y de los biomarcadores de da\u00f1o mioc\u00e1rdico tras intervenciones de cirug\u00eda card\u00edaca con circulaci\u00f3n extracorp\u00f3rea (cec). material y m\u00e9todos: estudiamos una cohorte prospectiva de 138 pacientes que fueron intervenidos de cirug\u00eda coronaria y valvular con cec. Diferenciamos dos grupos de estudio: enfermos con (grupo a) o sin (grupo b) estatinas. Se midieron los niveles plasm\u00e1ticos de las \u00c2\u00a1nterleuquinas pro-inflamatorias (factor de necrosis tumoral alfa [tnf-a], interleuquina [ilj-6, il-8 e il-2r) y de cpk, cpk mb y troponina i antes y 1, 6, 24, y > 72 horas despu\u00e9s de la cirug\u00eda. resultados: las caracter\u00edsticas b\u00e1sales, operatorias y la morbi-mortalidad postquir\u00fargica de los dos grupos fueron similares. El grupo a obtuvo niveles postquir\u00fargicos de il-6 a \u00f1as 6 horas, 24 horas y antes del alta hospitalaria, as\u00ed como niveles medios de il-6 postquir\u00fargicos en las primeras 24 horas, significativamente inferiores a los del grupo b. Las cifras de cpk mb y de troponina i postquir\u00fargicas tambi\u00e9n resultaron significativamente menores en el grupo a tratamiento preoperatorio con estatinas. conclusiones: demostramos por primera vez en la literatura que el tratamiento preoperatorio con estatinas disminuye la ris, as\u00ed como el da\u00f1o mioc\u00e1rdico, observado tras intervenciones de cirug\u00eda cardiaca con cec, independientemente de que sea cirug\u00eda de revascularizaci\u00f3n coronaria o cirug\u00eda valvular.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos del tratamiento preoperatorio con estatinas sobre la respuesta inflamatoria sist\u00e9mica y el da\u00f1o mioc\u00e1rdico tras intervenciones card\u00edacas con circulaci\u00f3n extracorp\u00f3rea.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos del tratamiento preoperatorio con estatinas sobre la respuesta inflamatoria sist\u00e9mica y el da\u00f1o mioc\u00e1rdico tras intervenciones card\u00edacas con circulaci\u00f3n extracorp\u00f3rea. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Manuel Martinez Comendador <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/06\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Rubio \u00e1lvarez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 benito Garcia bengoechea gonzalez moro <\/li>\n<li>joaquin Gomez gomez (vocal)<\/li>\n<li>tomas Fernandez de sevilla ribosa (vocal)<\/li>\n<li>Jos\u00e9 Carlos Diz g\u00f3mez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Manuel Martinez Comendador Objetivos: determinar si el tratamiento preoperatorio con estatinas se asocia a una disminuci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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