{"id":65251,"date":"2018-03-09T22:53:21","date_gmt":"2018-03-09T22:53:21","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-las-proteinas-tirosin-kinasa-en-los-carcinomas-de-celulas-escamosas-de-cabeza-y-cuello\/"},"modified":"2018-03-09T22:53:21","modified_gmt":"2018-03-09T22:53:21","slug":"papel-de-las-proteinas-tirosin-kinasa-en-los-carcinomas-de-celulas-escamosas-de-cabeza-y-cuello","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/oncologia\/papel-de-las-proteinas-tirosin-kinasa-en-los-carcinomas-de-celulas-escamosas-de-cabeza-y-cuello\/","title":{"rendered":"Papel de las proteinas tirosin kinasa en los carcinomas de celulas escamosas de cabeza y cuello"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Xabier Altuna Mariezcurrena <\/strong><\/h2>\n<p>El objetivo del presente trabajo es determinar si sti-571 &#8211; imatinib mesylate (gleevecr) puede sensibilizar a los carcinomas de celulas escamosas de cabeza y cuello a los efectos del quimioterapico cisplatino. para ello, en primer lugar se realiza un analisis inmunohistoquimico para ver la expresion de las moleculas que son dianas del farmaco gleevecr entre las que se encuentran c-kit, c-abl y pdgfr en muestras de carcinomas de cabeza y cuello. Posteriormente se realiza un analisis por western blot para examinar la expresion de estas moleculas en dos lineas celulares de carcinoma de cabeza y cuello. una vez confirmadas que estas moleculas diana estan presentes en los tejidos y en las lineas celulares estudiadas, se realiza un test de supervivencia celular para determinar el efecto del farmaco sobre el crecimiento y la proliferacion de estas celulas. los resultados obtenidos indican que gleevecr potencia el efecto del cisplatino y conduce a un descenso significativo en la proliferacion celular y en la formacion de colonias si lo comparamos con cisplatino solo, y lo hace de una forma dosis dependiente.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de las proteinas tirosin kinasa en los carcinomas de celulas escamosas de cabeza y cuello<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de las proteinas tirosin kinasa en los carcinomas de celulas escamosas de cabeza y cuello <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Xabier Altuna Mariezcurrena <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/06\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Algaba Guimera<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos Suarez nieto <\/li>\n<li>Manuel Bernal sprekelsen (vocal)<\/li>\n<li>Jaime Marco algarra (vocal)<\/li>\n<li>Jos\u00e9 Carlos Vea orte (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Xabier Altuna Mariezcurrena El objetivo del presente trabajo es determinar si sti-571 &#8211; imatinib mesylate (gleevecr) puede [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[36483,1543,1027,12909],"tags":[25235,25303,56311,143921,85336,143920],"class_list":["post-65251","post","type-post","status-publish","format-standard","hentry","category-biologia-molecular","category-cirugia-de-garganta-nariz-y-oidos","category-oncologia","category-pais-vasco-euskal-herriko-unibertsitatea","tag-carlos-suarez-nieto","tag-jaime-marco-algarra","tag-jesus-algaba-guimera","tag-jose-carlos-vea-orte","tag-manuel-bernal-sprekelsen","tag-xabier-altuna-mariezcurrena"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/65251","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=65251"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/65251\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=65251"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=65251"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=65251"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}