{"id":65271,"date":"2018-03-09T22:53:21","date_gmt":"2018-03-09T22:53:21","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-valor-patogenico-de-la-expresion-y-ruta-de-senalizacion-de-kit-e-igf1r-en-sarcoma-de-ewing-anuevas-posibles-dianas-terapeuticas\/"},"modified":"2018-03-09T22:53:21","modified_gmt":"2018-03-09T22:53:21","slug":"estudio-del-valor-patogenico-de-la-expresion-y-ruta-de-senalizacion-de-kit-e-igf1r-en-sarcoma-de-ewing-anuevas-posibles-dianas-terapeuticas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/salamanca\/estudio-del-valor-patogenico-de-la-expresion-y-ruta-de-senalizacion-de-kit-e-igf1r-en-sarcoma-de-ewing-anuevas-posibles-dianas-terapeuticas\/","title":{"rendered":"Estudio del valor patog\u00e9nico de la expresi\u00f3n y ruta de se\u00f1alizaci\u00f3n de kit e igf1r en sarcoma de ewing: \u00c2\u00bfnuevas posibles dianas terap\u00e9uticas?"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Sofia Da Silva Martins <\/strong><\/h2>\n<p>Los sarcomas de ewing (se) son tumores \u00f3seos y de partes blandas, que presentan una mayor incidencia en ni\u00f1os y j\u00f3venes adultos, siendo la segunda neoplasia m\u00e1s frecuente en los tumores primarios del hueso de pacientes pedi\u00e1tricos (16% de los tumores malignos), siendo la supervivencia a los 5 a\u00f1os de apenas un 50%. la b\u00fasqueda de nuevas formas de tratar los sarcomas es una necesidad urgente. El estudio y clarificaci\u00f3n de los procesos que regulan el desarrollo y progresi\u00f3n tumoral es, desde luego, uno de los aspectos m\u00e1s importantes para que se pueden dise\u00f1ar nuevas terapias \u00abeficazmente dirigidas\u00bb.  en este trabajo se han estudiado la implicaci\u00f3n de la ruta de se\u00f1alizaci\u00f3n de igf1r en el se y cu\u00e1les son los efectos de su inhibici\u00f3n, verific\u00e1ndose que era esencial para la proliferaci\u00f3n y supervivencia celulares. Se han estudiado posibles combinaciones con la inhibici\u00f3n de c-kit y la terapia convencional (doxorubicina y vincristina), obteni\u00e9ndose efectos sin\u00e9rgicos, present\u00e1ndose nuevas potenciales aplicaciones cl\u00ednicas. con estudios de prote\u00f3mica, se ha comprobado una expresi\u00f3n alterada de varias prote\u00ednas de choque t\u00e9rmico (hsps) en l\u00edneas celulares de se tratadas con inhibidores de igf1r\/c-kit, habi\u00e9ndose decidido estudiar m\u00e1s en detalle la implicaci\u00f3n de hsp90 en el se. Se ha verificado que su expresi\u00f3n estaba incrementada en aquellas l\u00edneas celulares resistentes a los efectos de la inhibici\u00f3n de igf1r\/c-kit y que su inhibici\u00f3n ten\u00eda efectos sensibilizadores al tratamiento, incluso en modelos xen\u00f3grafos, sugiri\u00e9ndose nuevos mecanismos de resistencia al tratamiento no descritos hasta el momento en el se. Los resultados obtenidos en este trabajo indican posibles aplicaciones cl\u00ednicas de la inhibici\u00f3n de igf1r y hsp90.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio del valor patog\u00e9nico de la expresi\u00f3n y ruta de se\u00f1alizaci\u00f3n de kit e igf1r en sarcoma de ewing: \u00c2\u00bfnuevas posibles dianas terap\u00e9uticas?<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio del valor patog\u00e9nico de la expresi\u00f3n y ruta de se\u00f1alizaci\u00f3n de kit e igf1r en sarcoma de ewing: \u00c2\u00bfnuevas posibles dianas terap\u00e9uticas? <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Sofia Da Silva Martins <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/06\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Enrique De \u00e1lava Casado<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco javier Pardo mind\u00e1n <\/li>\n<li>teresa Flores corral (vocal)<\/li>\n<li>Francisco Javier Alonso garcia de la rosa (vocal)<\/li>\n<li>jaume Mora graupera (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Sofia Da Silva Martins Los sarcomas de ewing (se) son tumores \u00f3seos y de partes blandas, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9386],"tags":[143968,17769,36152,2940,138076,9544],"class_list":["post-65271","post","type-post","status-publish","format-standard","hentry","category-salamanca","tag-ana-sofia-da-silva-martins","tag-enrique-de-alava-casado","tag-francisco-javier-alonso-garcia-de-la-rosa","tag-francisco-javier-pardo-mindan","tag-jaume-mora-graupera","tag-teresa-flores-corral"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/65271","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=65271"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/65271\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=65271"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=65271"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=65271"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}