{"id":65342,"date":"2018-03-09T22:53:25","date_gmt":"2018-03-09T22:53:25","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/el-receptor-tipo-opioide-orl1-en-los-gash-sal-una-nueva-la%c2%adnea-de-hamsters-sirios-con-epilepsia-audiogena\/"},"modified":"2018-03-09T22:53:25","modified_gmt":"2018-03-09T22:53:25","slug":"el-receptor-tipo-opioide-orl1-en-los-gash-sal-una-nueva-la%c2%adnea-de-hamsters-sirios-con-epilepsia-audiogena","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/neuropatologia\/el-receptor-tipo-opioide-orl1-en-los-gash-sal-una-nueva-la%c2%adnea-de-hamsters-sirios-con-epilepsia-audiogena\/","title":{"rendered":"El receptor tipo opioide orl1 en los gash: sal, una nueva l\u00ednea de h\u00e1msters sirios con epilepsia audi\u00f3gena"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Luis Fernando Barrios Rodr\u00edguez <\/strong><\/h2>\n<p>Esta tesis doctoral presenta un estudio sobre la implicaci\u00f3n del opioide orl1 en las crisis epil\u00e9pticas a partir de experimentos hechos en un modelo animal que presenta convulsiones audi\u00f3genas, el h\u00e1mster gash:sal. el receptor opi\u00e1ceo con las caracter\u00edsticas estructurales llamadas orl1 (receptor-como los opioides 1) reconoce que participan en m\u00faltiples funciones de la organizaci\u00f3n del sistema nervioso central (snc). Recientemente se ha observado que orl1 podr\u00eda estar jugando un papel clave en las incautaciones de considerar s\u00edndromes epil\u00e9pticos. Se estudi\u00f3 la expresi\u00f3n de receptores de orl1 en las regiones del cerebro que mostraron una mayor actividad en la aparici\u00f3n y desarrollo de las crisis epil\u00e9pticas en un nuevo modelo animal de h\u00e1msters sirios (mesocricetus auratus) con una epilepsia audiog\u00e9nico, llamado gash: sal. Nuestro trabajo ha sido clonado y descrito por primera vez la presencia del receptor del h\u00e1mster del snc (maorl), el gen que codifica el receptor, mostrar\u00e1 una secuencia de 1104 pb con la m\u00e1s alta homolog\u00eda en la secuencia de nucle\u00f3tidos con la rata y el rat\u00f3n receptor orl1. Tras el estallido de la crisis gash: sal tiene una alta densidad de inmunoreactividad neuronas de la prote\u00edna fos en el n\u00facleo del tronco cerebral diversos, especialmente en el col\u00edculo inferior todas sus subn\u00facleo y el gris periacueductal. Las neuronas del inmunopositive orl1 receptor tambi\u00e9n se encuentra en las regiones del col\u00edculo inferior que expresa la prote\u00edna fos con la mayor densidad de inmunoreactividad neuronal en el n\u00facleo central del col\u00edculo inferior y una menor densidad de la corteza dorsal y externa. En los animales de control no se observaron inmunoreactividad neuronal para orl1 receptor.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>El receptor tipo opioide orl1 en los gash: sal, una nueva l\u00ednea de h\u00e1msters sirios con epilepsia audi\u00f3gena<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 El receptor tipo opioide orl1 en los gash: sal, una nueva l\u00ednea de h\u00e1msters sirios con epilepsia audi\u00f3gena <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Luis Fernando Barrios Rodr\u00edguez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/06\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Raquel Emilia Rodr\u00edguez Rodr\u00edguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rafael Cove\u00f1as rodr\u00edguez <\/li>\n<li>adalberto Benito hernandez (vocal)<\/li>\n<li>natividad Garc\u00eda atar\u00e9s (vocal)<\/li>\n<li>Jos\u00e9 de anchieta de Castro horta junior (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Luis Fernando Barrios Rodr\u00edguez Esta tesis doctoral presenta un estudio sobre la implicaci\u00f3n del opioide orl1 en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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