{"id":65377,"date":"2018-03-09T22:53:29","date_gmt":"2018-03-09T22:53:29","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/respuesta-celular-a-dosis-subtermicas-de-corrientes-electricas-de-057-mhz\/"},"modified":"2018-03-09T22:53:29","modified_gmt":"2018-03-09T22:53:29","slug":"respuesta-celular-a-dosis-subtermicas-de-corrientes-electricas-de-057-mhz","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/respuesta-celular-a-dosis-subtermicas-de-corrientes-electricas-de-057-mhz\/","title":{"rendered":"Respuesta celular a dosis subt\u00e9rmicas de corrientes el\u00e9ctricas de 0,57 mhz"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda Luisa Hern\u00e1ndez Bule <\/strong><\/h2>\n<p>La terapia el\u00e9ctrica capacitiva resistiva es una t\u00e9cnica no invasiva que se aplica habitualmente para el tratamiento de lesiones cut\u00e1neas, \u00f3seas, musculares y tendinosas. Esta terapia emplea corrientes el\u00e9ctricas de entre 0,45 y 0,6 mhz  para inducir hipertermia en los tejidos profundos blanco del tratamiento.  Debido a que esta terapia se ha mostrado m\u00e1s efectiva que otros tratamientos electrot\u00e9rmicos, se ha propuesto la posibilidad de que exista un efecto sin\u00e9rgico de las corrientes el\u00e9ctricas terc y la hipertermia inducida.  El presente trabajo investiga los efectos de la corriente el\u00e9ctrica de 0,57 mhz , aplicada a densidades subt\u00e9rmicas, en cultivos de c\u00e9lulas cancerosas y no cancerosas de origen humano.  El estudio en c\u00e9lulas de hepatocarcinoma humano hepg2 muestra un efecto citost\u00e1tico en parte de la poblaci\u00f3n celular. Esta citostasis parece ligada a alteraciones electro-inducidas en los niveles de expresi\u00f3n y activaci\u00f3n de prote\u00ednas de control del ciclo celular (ciclinas d1, a y b1) e inhibidores del ciclo celular (p27 y p53) entre otras.  Tales alteraciones inducen bloqueos o prolongaciones en fases espec\u00edficas del ciclo celular y, como consecuencia, determinar\u00edan una ca\u00edda final en la densidad celular de los cultivos tratados con terc.  Por otro lado, los estudios realizados en la l\u00ednea de neuroblastoma humano nb69, con una tasa de crecimiento mayor a hepg2, muestran efectos citot\u00f3xicos en una parte de la poblaci\u00f3n celular, durante y despu\u00e9s de aplicar las corrientes el\u00e9ctricas terc. Adicionalmente, los estudios en c\u00e9lulas mononucleares de sangre perif\u00e9rica humana (pbmcs), quiescentes en ausencia de ant\u00edgeno, muestran que la viabilidad celular de estos cultivos no se ve alterada por el tratamiento el\u00e9ctrico terc.  En conjunto, los resultados obtenidos en las condiciones experimentales ensayadas sobre c\u00e9lulas cancerosas y no cancerosas no muestran indicios de efectos adversos de la terapia, y abren la posibilidad de extender las aplicaciones del tratamiento terc a otros \u00e1mbitos terap\u00e9uticos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Respuesta celular a dosis subt\u00e9rmicas de corrientes el\u00e9ctricas de 0,57 mhz<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Respuesta celular a dosis subt\u00e9rmicas de corrientes el\u00e9ctricas de 0,57 mhz <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda Luisa Hern\u00e1ndez Bule <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/06\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alejandro Ubeda Maeso<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Fernandez piqueras <\/li>\n<li>sebasti\u00e1 Sendr\u00f3s tolsau (vocal)<\/li>\n<li>Mar\u00eda  angeles Trillo ruiz (vocal)<\/li>\n<li>ernesto Roldan Santiago (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Luisa Hern\u00e1ndez Bule La terapia el\u00e9ctrica capacitiva resistiva es una t\u00e9cnica no invasiva que se aplica [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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