{"id":65384,"date":"2018-03-09T22:53:29","date_gmt":"2018-03-09T22:53:29","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulation-of-nfta5-by-signaling-pathways-involved-in-osmotic-stress-responses-and-cell-growth\/"},"modified":"2018-03-09T22:53:29","modified_gmt":"2018-03-09T22:53:29","slug":"regulation-of-nfta5-by-signaling-pathways-involved-in-osmotic-stress-responses-and-cell-growth","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/biologia-celular\/regulation-of-nfta5-by-signaling-pathways-involved-in-osmotic-stress-responses-and-cell-growth\/","title":{"rendered":"Regulation of nfta5 by signaling pathways involved in osmotic stress responses and cell growth"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Beatriz Morancho Armisen <\/strong><\/h2>\n<p>Nfat5 es el principal regulador del programa de genes osmoprotector que se activa en respuesta a estr\u00e9s osm\u00f3tico. La hipertonicidad causa un aumento en la concentraci\u00f3n intracelular de iones inorg\u00e1nicos que es perjudicial para la c\u00e9lula y los genes regulados por nfat5 permiten la acumulaci\u00f3n de osmolitos org\u00e1nicos y chaperonas para proteger a la c\u00e9lula de este estr\u00e9s. Sin embargo, se desconocen los umbrales fisiopatol\u00f3gicos que inducen la activaci\u00f3n transcripcional de nfat5, y que v\u00edas de se\u00f1alizaci\u00f3n est\u00e1n involucradas, en c\u00e9lulas primarias. %&#038;\/En nuestro trabajo hemos estudiado la regulaci\u00f3n de la actividad transcripcional de nfat5 en diversos tipos de c\u00e9lulas primarias obtenidas a partir de ratones transg\u00e9nicos con el gen reportero 9xnfat-luc desarrollado por el laboratorio del dr. Molkentin. Nuestros resultados indican que nfat5 es capaz de responder a niveles patol\u00f3gicos de tonicidad en c\u00e9lulas primarias y requiere una combinaci\u00f3n de v\u00edas de se\u00f1alizaci\u00f3n, algunas de las cuales son m\u00e1s relevantes en determinados tipos celulares.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulation of nfta5 by signaling pathways involved in osmotic stress responses and cell growth<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulation of nfta5 by signaling pathways involved in osmotic stress responses and cell growth <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Beatriz Morancho Armisen <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pompeu fabra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/06\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Francisco Aramburu Beltran<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: francesc Posas garriga <\/li>\n<li>Jos\u00e9 ramon Bayascas ram\u00edrez (vocal)<\/li>\n<li>Juan  Miguel Redondo moya (vocal)<\/li>\n<li>carme Caelles franch (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Beatriz Morancho Armisen Nfat5 es el principal regulador del programa de genes osmoprotector que se activa en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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