{"id":65417,"date":"2018-03-09T22:53:29","date_gmt":"2018-03-09T22:53:29","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/alteraciones-de-la-glicosilacion-de-la-transferrina-estudio-de-su-utilidad-cla%c2%adnica-como-marcador-de-disfuncion-metabolica\/"},"modified":"2018-03-09T22:53:29","modified_gmt":"2018-03-09T22:53:29","slug":"alteraciones-de-la-glicosilacion-de-la-transferrina-estudio-de-su-utilidad-cla%c2%adnica-como-marcador-de-disfuncion-metabolica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-clinicas\/alteraciones-de-la-glicosilacion-de-la-transferrina-estudio-de-su-utilidad-cla%c2%adnica-como-marcador-de-disfuncion-metabolica\/","title":{"rendered":"Alteraciones de la glicosilaci\u00f3n de la transferrina. estudio de su  utilidad cl\u00ednica como marcador de disfunci\u00f3n metab\u00f3lica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carlos Garrido-allepuz Herrera <\/strong><\/h2>\n<p>Numerosas prote\u00ednas tienen en su composici\u00f3n estructuras oligosacar\u00eddicas tambi\u00e9n denominadas glicanos, unidas a su cadena polipept\u00eddica. Esta estructura glucoproteica la comparten muchas de las proteinas extracelulares, como la proteina s\u00e9rica transferrina o los factores de coagulaci\u00f3n, la mayor parte de las prote\u00ednas de membrana, y algunas de las prote\u00ednas intracelulares como son las enzimas lisosomales. La diversidad de organelas intracelulares implicadas en los procesos de glicosilaci\u00f3n y la complejidad de este proceso intracelular, sugieren que diferentes alteraciones en la homeostasis o metabolismo celular podr\u00edan verse reflejadas en cambios en los patrones de glicosilaci\u00f3n normal de determinadas biomol\u00e9culas. En pediatr\u00eda son varias las situaciones cl\u00ednicas en las que la identificaci\u00f3n de cambios en los patrones normales de glicosilaci\u00f3n podr\u00eda aportar datos de inter\u00e9s diagn\u00f3stico, pron\u00f3st ico y de seguimiento o respuesta a diferentes tratamientos. Con estos  antecedentes que ser\u00e1n analizados en detalle en los cap\u00edtulos siguientes, fue planteada esta tesis cuyo objetivo es investigar la posible existencia de defectos de la glicosilaci\u00f3n en prote\u00ednas s\u00e9ricas de pac ientes pedi\u00e1tricos con potencial alteraci\u00f3n en el metabolismo celular hep\u00e1tico. De acuerdo a nuestros resultados, el estudio de los patronesde glicosilaci\u00f3n permite identificar individuos con una disfunci\u00f3n cellar significativa manifestada, hepatopat\u00eda y disfunci\u00f3n metab\u00f3lica. En individuos portadores del alero z de la prote\u00edna alfa-1 antitripsina (aat), el estudio de la glicosilaci\u00f3n de la transferrina permitir\u00eda identificar de forma precoz un da\u00f1o hep\u00e1tico con una posible repercusi\u00f3n cl\u00ednica, independientemente de las alteraciones en el perfil bioqu\u00edmico de sus enzimas hep\u00e1ticos. El estudio de los patrones de hipoglicosilaci\u00f3n de la transferrinas parece ser muy sensible en la identificaci\u00f3n de m\u00ednimas disfunciones hep\u00e1ticas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alteraciones de la glicosilaci\u00f3n de la transferrina. estudio de su  utilidad cl\u00ednica como marcador de disfunci\u00f3n metab\u00f3lica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alteraciones de la glicosilaci\u00f3n de la transferrina. estudio de su  utilidad cl\u00ednica como marcador de disfunci\u00f3n metab\u00f3lica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carlos Garrido-allepuz Herrera <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Cantabria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/06\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>lamu\u00f1o Leguina Gonzalez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel Garcia fuentes <\/li>\n<li>pablo Sanjurjo crespo (vocal)<\/li>\n<li>Jes\u00fas Merino perez (vocal)<\/li>\n<li>Mar\u00eda  angeles Ros lasierra (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carlos Garrido-allepuz Herrera Numerosas prote\u00ednas tienen en su composici\u00f3n estructuras oligosacar\u00eddicas tambi\u00e9n denominadas glicanos, unidas a su [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[10518,155,817],"tags":[144280,10670,60680,43805,10555,11808],"class_list":["post-65417","post","type-post","status-publish","format-standard","hentry","category-cantabria","category-ciencias-clinicas","category-fisiologia-humana","tag-carlos-garrido-allepuz-herrera","tag-jesus-merino-perez","tag-lamuno-leguina-gonzalez","tag-maria-angeles-ros-lasierra","tag-miguel-garcia-fuentes","tag-pablo-sanjurjo-crespo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/65417","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=65417"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/65417\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=65417"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=65417"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=65417"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}