{"id":65447,"date":"2018-03-09T22:53:33","date_gmt":"2018-03-09T22:53:33","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/diseno-y-validacion-de-un-modelo-de-camara-corneal-aplicacion-al-estudio-de-permeacion-ocular-de-diferentes-formas-de-administracion-de-diclofenaco\/"},"modified":"2018-03-09T22:53:33","modified_gmt":"2018-03-09T22:53:33","slug":"diseno-y-validacion-de-un-modelo-de-camara-corneal-aplicacion-al-estudio-de-permeacion-ocular-de-diferentes-formas-de-administracion-de-diclofenaco","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/analisis-de-farmacos\/diseno-y-validacion-de-un-modelo-de-camara-corneal-aplicacion-al-estudio-de-permeacion-ocular-de-diferentes-formas-de-administracion-de-diclofenaco\/","title":{"rendered":"Dise\u00f1o y validaci\u00f3n de un modelo de c\u00e1mara corneal. aplicaci\u00f3n al estudio de permeaci\u00f3n ocular de diferentes formas de administraci\u00f3n de diclofenaco"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Roger Valls Foix <\/strong><\/h2>\n<p>* se ha dise\u00f1ado y evaluado un modelo de c\u00e1mara corneal de dos compartimientos (epitelial y endotelial) para estudios de permeaci\u00f3n \u00abex vivo\u00bb de f\u00e1rmacos a trav\u00e9s de c\u00f3rneas de conejo. El dispositivo permite, adem\u00e1s, la medici\u00f3n y registro del potencial corneal, que proporciona informaci\u00f3n sobre la viabilidad de la membrana corneal. La validaci\u00f3n del instrumento, se realiz\u00f3 con fluoresce\u00edna, obteni\u00e9ndose valores correctos de repetibilidad, precisi\u00f3n intermedia, linealidad y robustez. En estudios de inyecci\u00f3n del f\u00e1rmaco y posterior lavado con l\u00e1grima, la aplicaci\u00f3n de un modelo farmacocin\u00e9tico es un buen m\u00e9todo para comparar formulaciones. A tiempos cortos, el c\u00e1lculo de la permeabilidad aparente, puede dar una buena aproximaci\u00f3n. * se ha estudiado la penetraci\u00f3n de diclofenaco s\u00f3dico, a diferentes concentraciones en el modelo de c\u00e1mara corneal desarrollado, compar\u00e1ndola con el colirio comercial de diclofenaco. El colirio comercial (diclofenaco lepori\u00c2\u00ae presenta mejores resultados en los modelos con lavado de l\u00e1grima lo que se atribuye a su composici\u00f3n que incluye tensiactivos y agentes viscosizantes. El comportamiento del diclofenaco s\u00f3dico en los estudios donde la concentraci\u00f3n en el compartimiento epitelial se mantiene constante presenta mejores resultados a largo plazo. * se han preparado y caracterizado complejos de inclusi\u00f3n de diclofenaco s\u00f3dico con beta-ciclodextrinas por amasado, un m\u00e9todo secillo y pr\u00e1ctico de preparaci\u00f3n, que da unos rendimientos buenos. * la permeaci\u00f3n de diclofenaco s\u00f3dico asociado a beta-ciclodextrinas a trav\u00e9s de la membrana corneal, en el dispositivo desarrollado, ha puesto de manifiesto un coeficiente de permeaci\u00f3n m\u00e1s elevado que el del f\u00e1rmaco libre. Comparando estos resultados con los de la especialidad comercial conteniendo gamma-ciclodextrinas (voltaren\u00c2\u00ae colirio), se observa una mayor permeaci\u00f3n de esta \u00faltima, debido a la presencia de otros coadyuvantes en la formulaci\u00f3n.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Dise\u00f1o y validaci\u00f3n de un modelo de c\u00e1mara corneal. aplicaci\u00f3n al estudio de permeaci\u00f3n ocular de diferentes formas de administraci\u00f3n de diclofenaco<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Dise\u00f1o y validaci\u00f3n de un modelo de c\u00e1mara corneal. aplicaci\u00f3n al estudio de permeaci\u00f3n ocular de diferentes formas de administraci\u00f3n de diclofenaco <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Roger Valls Foix <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/06\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Oriol Valls Planells<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: benito Del castillo garcia <\/li>\n<li>Francisco Zaragoza garcia (vocal)<\/li>\n<li>xavier Pag\u00e9s rovira (vocal)<\/li>\n<li>Mar\u00eda  asuncion Alsina esteller (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Roger Valls Foix * se ha dise\u00f1ado y evaluado un modelo de c\u00e1mara corneal de dos compartimientos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[339,951],"tags":[4776,4080,11947,1377,144340,144341],"class_list":["post-65447","post","type-post","status-publish","format-standard","hentry","category-analisis-de-farmacos","category-barcelona","tag-benito-del-castillo-garcia","tag-francisco-zaragoza-garcia","tag-maria-asuncion-alsina-esteller","tag-oriol-valls-planells","tag-roger-valls-foix","tag-xavier-pages-rovira"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/65447","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=65447"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/65447\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=65447"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=65447"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=65447"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}