{"id":65506,"date":"2018-03-09T22:53:37","date_gmt":"2018-03-09T22:53:37","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-inmunomodulador-de-la-melatonina-en-modelos-experimentales-de-la-infeccion-por-el-virus-de-encefalitis-equina-venezolana\/"},"modified":"2018-03-09T22:53:37","modified_gmt":"2018-03-09T22:53:37","slug":"efecto-inmunomodulador-de-la-melatonina-en-modelos-experimentales-de-la-infeccion-por-el-virus-de-encefalitis-equina-venezolana","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/inmunopatologia\/efecto-inmunomodulador-de-la-melatonina-en-modelos-experimentales-de-la-infeccion-por-el-virus-de-encefalitis-equina-venezolana\/","title":{"rendered":"Efecto inmunomodulador de la melatonina en modelos experimentales de la infecci\u00f3n por el virus de encefalitis equina venezolana"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Nereida Josefina Valero Cede\u00f1o <\/strong><\/h2>\n<p>De este trabajo experimental de an\u00e1lisis in vivo e in vitro del efecto inmunomodulador de la melatonina en modelos experimentales de infecci\u00f3n por el eev, se deducen las siguientes conclusiones:  1.\tEl tratamiento preventivo y mantenido con mlt ejerce un efecto protector en ratones infectados por el virus de eev, aumentando la supervivencia.  2.\tEl tratamiento con mlt induce un efecto inmunomodulador sobre los animales infectados con eev que se caracteriza por un incremento de los niveles citocinas proinflamatorias y de patr\u00f3n th1, predominando la elevaci\u00f3n de la il-1\u00edY. El impacto terap\u00e9utico de este aumento de la il-1\u00edY se considera muy relevante ya que la deprivaci\u00f3n funcional de esta citosina se asocia a una dram\u00e1tica mortalidad.  3.\tLa mlt induce un efecto antioxidante en los animales infectados con eev.  4.\tLa administraci\u00f3n de lz bloquea el efecto terap\u00e9utico de la mlt, por lo que el mecanismo de acci\u00f3n de la administraci\u00f3n ex\u00f3gena de esta neurohormona se ejerce a trav\u00e9s de su interacci\u00f3n con sus receptores espec\u00edficos.  5.\tMlt inhibe el efecto citop\u00e1tico del virus eev en cultivo celulares sin poseer una acci\u00f3n directa sobre su replicaci\u00f3n.  6.\tTomados en conjunto estos resultados se concluye que mlt posee un efecto terap\u00e9utico sobre la infecci\u00f3n por el virus de la eev, cuya relevancia cl\u00ednica deber\u00e1 establecerse en futuros trabajos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto inmunomodulador de la melatonina en modelos experimentales de la infecci\u00f3n por el virus de encefalitis equina venezolana<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto inmunomodulador de la melatonina en modelos experimentales de la infecci\u00f3n por el virus de encefalitis equina venezolana <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Nereida Josefina Valero Cede\u00f1o <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/06\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Melchor Alvarez De Mon Soto<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Rodriguez zapata <\/li>\n<li>Juan  Manuel Casas fernandez de tejerina (vocal)<\/li>\n<li>M\u00aa del puerto Hernandez (vocal)<\/li>\n<li>Jos\u00e9 Antonio Gir\u00f3n gonz\u00e1lez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Nereida Josefina Valero Cede\u00f1o De este trabajo experimental de an\u00e1lisis in vivo e in vitro del efecto [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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