{"id":65610,"date":"2018-03-09T22:53:45","date_gmt":"2018-03-09T22:53:45","guid":{"rendered":""},"modified":"2018-03-09T22:53:45","modified_gmt":"2018-03-09T22:53:45","slug":"towards-coenzyme-q-biosynthesis-regulation-in-mammals-nf-kb-activation-of-coq7-hacia-la-regulacion-de-la-biosa%c2%adntesis-del-coenzima-q-en-mama%c2%adferos-activacion-transcripcional-de-coq7-media","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica-molecular\/towards-coenzyme-q-biosynthesis-regulation-in-mammals-nf-kb-activation-of-coq7-hacia-la-regulacion-de-la-biosa%c2%adntesis-del-coenzima-q-en-mama%c2%adferos-activacion-transcripcional-de-coq7-media\/","title":{"rendered":"Towards coenzyme q biosynthesis regulation in mammals. nf-kb activation of coq7 (hacia la regulaci\u00f3n de la bios\u00edntesis del coenzima q en mam\u00edferos. activaci\u00f3n transcripcional de coq7 mediada por nf-kb)"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Gloria Teresa Brea Calvo <\/strong><\/h2>\n<p>La camptotecina (cpt) es un citot\u00f3xico inhibe la topoisomerasa 1 y genera especies reactivas de ox\u00edgeno (ros), provocando apoptosis. La cpt induce la s\u00edntesis del coq, el \u00fanico antioxidante de naturaleza lip\u00eddica sintetizado end\u00f3genamente por las c\u00e9lulas. Adem\u00e1s, los niveles de ros y lipoperoxidaci\u00f3n aumentan en c\u00e9lulas tratadas con cpt cuya s\u00edntesis de coq est\u00e1 inhibida. Como consecuencia, estas c\u00e9lulas son m\u00e1s sensibles al tratamiento con el quimioter\u00e1pico. Posiblemente el coq sea un elemento del sistema de defensa frente al estr\u00e9s oxidativo inducido por los ros generados durante el tratamiento con cpt.  el mecanismo por el cual la cpt genera ros no se conoce actualmente. Nosotros hemos observado un aumento temprano en el potencial de membrana mitocondrial que se correlaciona con el aumento en los niveles de ros y una inhibici\u00f3n del consumo de ox\u00edgeno. Probablemente el quimioter\u00e1pico est\u00e9 modificando las propiedades de fluidez de la membrana mitocondrial, impidiendo la disipaci\u00f3n del gradiente de protones y causando el aumento de ros.               de entre los genes que participan en la ruta de bios\u00edntesis del coq destaca coq7, que parece tener no solo un papel enzim\u00e1tico sino tambi\u00e9n regulador de la ruta. Nosotros hemos observado una regulaci\u00f3n transcripcional de coq7 en respuesta a la cpt. El an\u00e1lisis del promotor del gen coq7 revela que contiene dos sitios funcionalmente activos de uni\u00f3n para nf-kb a los cuales el factor de transcripci\u00f3n se une en respuesta al quimioter\u00e1pico.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Towards coenzyme q biosynthesis regulation in mammals. nf-kb activation of coq7 (hacia la regulaci\u00f3n de la bios\u00edntesis del coenzima q en mam\u00edferos. activaci\u00f3n transcripcional de coq7 mediada por nf-kb)<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Towards coenzyme q biosynthesis regulation in mammals. nf-kb activation of coq7 (hacia la regulaci\u00f3n de la bios\u00edntesis del coenzima q en mam\u00edferos. activaci\u00f3n transcripcional de coq7 mediada por nf-kb) <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Gloria Teresa Brea Calvo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pablo de olavide<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/06\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pl\u00e1cido Navas Lloret<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Sobrino beneyto <\/li>\n<li>Jos\u00e9 Manuel Villalba montoro (vocal)<\/li>\n<li>Rafael Artuch iriberri (vocal)<\/li>\n<li>leonardo Salviati (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gloria Teresa Brea Calvo La camptotecina (cpt) es un citot\u00f3xico inhibe la topoisomerasa 1 y genera especies [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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