{"id":65680,"date":"2018-03-09T22:53:49","date_gmt":"2018-03-09T22:53:49","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/deteccion-molecular-de-los-astrovirus-humanos-y-caracterizacion-biologica-de-la-protea%c2%adna-estructural-vp26\/"},"modified":"2018-03-09T22:53:49","modified_gmt":"2018-03-09T22:53:49","slug":"deteccion-molecular-de-los-astrovirus-humanos-y-caracterizacion-biologica-de-la-protea%c2%adna-estructural-vp26","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/alicante\/deteccion-molecular-de-los-astrovirus-humanos-y-caracterizacion-biologica-de-la-protea%c2%adna-estructural-vp26\/","title":{"rendered":"Detecci\u00f3n molecular de los astrovirus humanos y caracterizaci\u00f3n biol\u00f3gica de la prote\u00edna estructural vp26"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jes\u00fas Enrique Royuela Casamayor <\/strong><\/h2>\n<p>Las gastroenteritis aguadas virales (geav) son un importante problema de salud p\u00fablica por su alta incidencia, causando una elevada morbi-motalidad en ni\u00f1os, principalmente en pa\u00edses en v\u00edas de desarrollo. Adem\u00e1s, constituye la segunda causa de las enfermedades transmitidas por alimentos, lo que supone elevados costes econ\u00f3micos. La hospitalizaci\u00f3n de ni\u00f1os con geav alcanza valores del 25-50% en nuestro pa\u00eds. Estudios realizados por gaggero (1998) y dalton (2002) indican que el astrovirus humano (hastv) es la segunda causa de geav en ni\u00f1os. Por otro lado, aspectos fundamentales de la biolog\u00eda de los astrovirus siguen siendo desconocidos. Actualmente no existe consenso en la composici\u00f3n y localizaci\u00f3n de las prote\u00ednas estructurales. A su vez, sigue sin haberse caracterizado en profundidad los ep\u00edtopos implicados en la antigenicidad e inmunogenicidad viral ni la funci\u00f3n de las prote\u00ednas estructurales, as\u00ed como los componentes m\u00ednimos necesarios para la formaci\u00f3n de viriones, etc. Por lo tanto, un an\u00e1lisis en detalle de estos aspectos b\u00e1sicos nos permitir\u00eda el dise\u00f1o de nuevos sistemas de prevenci\u00f3n y\/o tratamiento y de m\u00e9todos sensibles de detecci\u00f3n. En este trabajo hemos desarrollado un m\u00e9todo de rt-pcr en tiempo real que amplifica de forma sensible, espec\u00edfica, r\u00e1pida y en un solo paso los 8 serotipos de astrovirus humanos. Este m\u00e9todo ha sido aplicado a muestras cl\u00ednicas y se ha obtenido un 7.5% de falsos negativos, lo que indica que la incidencia de este agente productor de gastroenteritis est\u00e1 siendo infravalorada y que son necesarios nuevos m\u00e9todos de detecci\u00f3n para el diagn\u00f3stico molecular de las gastroenteritis por astrovirus. Adem\u00e1s, se ha realizado una caracterizaci\u00f3n bioqu\u00edmica, antig\u00e9nica y funcional de la prote\u00edna estructural vp26, poniendo de manifiesto que es una prote\u00edna que contiene ep\u00edtopos antig\u00e9nicos inmunodominantes y que est\u00e1 implicada funcionalmente en la uni\u00f3n a las c\u00e9lulas hu\u00e9sped.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Detecci\u00f3n molecular de los astrovirus humanos y caracterizaci\u00f3n biol\u00f3gica de la prote\u00edna estructural vp26<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Detecci\u00f3n molecular de los astrovirus humanos y caracterizaci\u00f3n biol\u00f3gica de la prote\u00edna estructural vp26 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jes\u00fas Enrique Royuela Casamayor <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alicante<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/06\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ana M. Falc\u00f3n Escalona<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: josefa Anton botella <\/li>\n<li>inmaculada Casas flecha (vocal)<\/li>\n<li>Marta Fogeda moreno (vocal)<\/li>\n<li>Francisco Mart\u00edn saavedra (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jes\u00fas Enrique Royuela Casamayor Las gastroenteritis aguadas virales (geav) son un importante problema de salud p\u00fablica por [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[19166],"tags":[79040,144800,144798,144797,65588,144799],"class_list":["post-65680","post","type-post","status-publish","format-standard","hentry","category-alicante","tag-ana-m-falcon-escalona","tag-francisco-martin-saavedra","tag-inmaculada-casas-flecha","tag-jesus-enrique-royuela-casamayor","tag-josefa-anton-botella","tag-marta-fogeda-moreno"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/65680","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=65680"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/65680\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=65680"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=65680"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=65680"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}