{"id":65685,"date":"2018-03-09T22:53:49","date_gmt":"2018-03-09T22:53:49","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-de-la-funcion-de-cdc14-flp1-en-la-respuesta-a-estres-genotoxico-en-schizosaccharomyces-pombe\/"},"modified":"2018-03-09T22:53:49","modified_gmt":"2018-03-09T22:53:49","slug":"analisis-de-la-funcion-de-cdc14-flp1-en-la-respuesta-a-estres-genotoxico-en-schizosaccharomyces-pombe","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/biologia-celular\/analisis-de-la-funcion-de-cdc14-flp1-en-la-respuesta-a-estres-genotoxico-en-schizosaccharomyces-pombe\/","title":{"rendered":"An\u00e1lisis de la funci\u00f3n de cdc14\/flp1 en la respuesta a estr\u00e9s genot\u00f3xico en schizosaccharomyces pombe"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Helena Diaz Cuervo <\/strong><\/h2>\n<p>El estudio presentado en esta tesis doctoral se centra en la investigaci\u00f3n de la funci\u00f3n de la fosfatasa flp1p de schizosaccharomyces pombe (tambi\u00e9n conocida como clp1p), perteneciente a la familia cdc14, en los mecanismos de vigilancia celular, especialmente en la cascada de se\u00f1alizaci\u00f3n en respuesta al estr\u00e9s replicativo y al da\u00f1o en el dna. Para ello se llevaron a cabo an\u00e1lisis gen\u00e9ticos y bioqu\u00edmicos comparados de las mencionadas respuestas en cepas silvestres y mutadas para flp1, as\u00ed como estudios de la expresi\u00f3n g\u00e9nica en respuesta a estr\u00e9s. En el marco de esta tesis se est\u00e1 desarrollando as\u00ed mismo un modelo matem\u00e1tico del checkpoint de replicaci\u00f3n en colaboraci\u00f3n con el grupo de biolog\u00eda computacional de sistemas del instituto max planck de gen\u00e9tica molecular de berl\u00edn, alemania. en esta tesis doctoral se ha demostrado la estrecha relaci\u00f3n de flp1p de s. Pombe, con la quinasa cds1p (principal efector del checkpoint de replicaci\u00f3n) en situaciones de estr\u00e9s replicativo y se describe por primera vez la implicaci\u00f3n de flp1p en el checkpoint de replicaci\u00f3n. La respuesta celular a estr\u00e9s replicativo produce la salida de flp1p al n\u00facleo, muy probablemente por medio de fosforilaci\u00f3n directa de la fosfatasa por cds1p. Por otra parte la actividad de cds1p en respuesta al checkpoint se ve reducida en c\u00e9lulas delecionadas para flp1p. La alteraci\u00f3n de los niveles proteicos de flp1p o de su localizaci\u00f3n resulta en la desregulaci\u00f3n de la respuesta a estr\u00e9s, produci\u00e9ndose efectos como p\u00e9rdida de eficiencia en el bloqueo de la progresi\u00f3n celular o la aparici\u00f3n de focos de recombinaci\u00f3n. Todas estas evidencias apuntan a que flp1p participa en la (auto-) regulaci\u00f3n del grado de activaci\u00f3n del checkpoint de replicaci\u00f3n necesario para una respuesta celular adecuada en situaciones de estr\u00e9s replicativo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis de la funci\u00f3n de cdc14\/flp1 en la respuesta a estr\u00e9s genot\u00f3xico en schizosaccharomyces pombe<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis de la funci\u00f3n de cdc14\/flp1 en la respuesta a estr\u00e9s genot\u00f3xico en schizosaccharomyces pombe <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Helena Diaz Cuervo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/06\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Andr\u00e9s Avelino Bueno Nu\u00f1ez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: sergio Moreno p\u00e9rez <\/li>\n<li>rosa Aligue alemany (vocal)<\/li>\n<li>Rafael Rodr\u00edguez daga (vocal)<\/li>\n<li>viesturs Simanis (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Helena Diaz Cuervo El estudio presentado en esta tesis doctoral se centra en la investigaci\u00f3n de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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