{"id":65756,"date":"2018-03-09T22:53:53","date_gmt":"2018-03-09T22:53:53","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/seguridad-eficacia-y-farmacocinetica-de-la-quimioembolizacion-del-carcinoma-hepatocelular-con-esferas-liberadoras-de-adriamicina\/"},"modified":"2018-03-09T22:53:53","modified_gmt":"2018-03-09T22:53:53","slug":"seguridad-eficacia-y-farmacocinetica-de-la-quimioembolizacion-del-carcinoma-hepatocelular-con-esferas-liberadoras-de-adriamicina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/seguridad-eficacia-y-farmacocinetica-de-la-quimioembolizacion-del-carcinoma-hepatocelular-con-esferas-liberadoras-de-adriamicina\/","title":{"rendered":"Seguridad, eficacia y farmacocin\u00e9tica de la quimioembolizaci\u00f3n del carcinoma hepatocelular con esferas liberadoras de adriamicina."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda Varela Calvo <\/strong><\/h2>\n<p>Esta tesis doctoral eval\u00faa la seguridad, eficacia y farmacocin\u00e9tica de la quimioembolizaci\u00f3n transarterial hep\u00e1tica utilizando esferas liberadoras de f\u00e1rmacos (drug eluting-beads, debs), un nuevo sistema embolizante dise\u00f1ado para liberar la quimioterapia lentamente y disminuir as\u00ed la toxicidad sist\u00e9mica. para ello se reclutaron 27 pacientes cirr\u00f3ticos child-pugh clase a (76% hombres, 59% vhc) con carcinoma hepatocelular multifocal no tatado previamente, a los que se les aplic\u00f3 la quimioembolizaci\u00f3n con las debs cargadas con adriamicina, a dosis ajustadas por la bilirrubina s\u00e9rica y la superficie corporal (rango 47-150 mg). los datos cl\u00ednicos y anal\u00edticos se recogieron a las 24 y 48 horas, 7, 14 y 30 d\u00edas tras la primera y la segunda deb-tace. La respuesta al tratamiento se evalu\u00f3 a los 6 meses mediante ct din\u00e1mico. para el an\u00e1lisis farmacocin\u00e9tico se obtuvieron muestras sangu\u00edneas en 13 pacientes a los 5, 20, 40, 60, 120 minutos, 6, 24, 48 y 168 horas para determinar la cmax de adriamicina y el auc. la deb-tace es bien tolerada, con un aceptable perfil de seguridad. hubo dos casos de absceso hep\u00e1tico, uno de ellos acab\u00f3 en fallecimiento. La tasa de respuesta al tratamiento fue del 75% (66.6% desde el punto de vista de intenci\u00f3n de tratar). la cmax de adriamicina y el auc fueron significativamente menores en los pacientes del grupo de deb-tace (78.97+ 38.3ng\/ml y 662.6 + 417.6ng\/ml x min.) Que en los pacientes tratados con tace convencional (2341.5 + 3951.9ng\/ml y 1812.2 + 1093.7ng\/ml x min., P = 0.00002 y p = 0.001, respectivamente). tras una mediana de seguimiento de 27.6 meses, la supervivencia a 1 y 2 a\u00f1os fue del 92.5 y del 88.9%, respectivamente.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Seguridad, eficacia y farmacocin\u00e9tica de la quimioembolizaci\u00f3n del carcinoma hepatocelular con esferas liberadoras de adriamicina.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Seguridad, eficacia y farmacocin\u00e9tica de la quimioembolizaci\u00f3n del carcinoma hepatocelular con esferas liberadoras de adriamicina. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda Varela Calvo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/06\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jordi Bruix Tud\u00f3<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda a. Buti Garc\u00eda <\/li>\n<li>lLuis Castells fuste (vocal)<\/li>\n<li>Manuel Rodr\u00edguez Garc\u00eda (vocal)<\/li>\n<li>joan Maurel santasusana (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Varela Calvo Esta tesis doctoral eval\u00faa la seguridad, eficacia y farmacocin\u00e9tica de la quimioembolizaci\u00f3n transarterial hep\u00e1tica [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,9],"tags":[58979,38953,144981,18129,144980,144979],"class_list":["post-65756","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-ciencias-medicas","tag-joan-maurel-santasusana","tag-jordi-bruix-tudo","tag-lluis-castells-fuste","tag-manuel-rodriguez-garcia","tag-maria-a-buti-garcia","tag-maria-varela-calvo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/65756","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=65756"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/65756\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=65756"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=65756"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=65756"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}