{"id":65785,"date":"2008-01-07T00:00:00","date_gmt":"2008-01-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/perfil-genetico-proinflamatorio-en-pacientes-con-enfermedad-oclusiva-severa-de-aorta-abdominal\/"},"modified":"2008-01-07T00:00:00","modified_gmt":"2008-01-07T00:00:00","slug":"perfil-genetico-proinflamatorio-en-pacientes-con-enfermedad-oclusiva-severa-de-aorta-abdominal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/perfil-genetico-proinflamatorio-en-pacientes-con-enfermedad-oclusiva-severa-de-aorta-abdominal\/","title":{"rendered":"Perfil gen\u00e9tico proinflamatorio en pacientes con enfermedad oclusiva severa de aorta abdominal"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Estrella Blanco Ca\u00f1ibano <\/strong><\/h2>\n<p>Introducci\u00f3n: la reacci\u00f3n inflamatoria es responsable del desarrollo y progresi\u00f3n de la aterosclerosis. Las variaciones gen\u00e9ticas individuales pueden predisponer a una respuesta inflamatoria incrementada a est\u00edmulos ambientales con el consecuente des arrollo de una mayor aterosclerosis. Como otras patolog\u00edas polig\u00e9nicas, la susceptibilidad gen\u00e9tica de cada individuo vendr\u00eda determinada por las interacciones de un cierto n\u00famero de alelos con diferentes efectos sobre el riesgo de desarrollar la enf ermedad.  Los polimorfismos de genes codificantes de mol\u00e9culas inflamatorias pueden deterimiar perfiles gen\u00e9ticos asociados con el mayor riesgo de progresi\u00f3n de enfermedades cardiovasculares objetivo: determinar el  papel que las variaciones en los g enes que codifican factores  inflamatorios pueda tener en el desarrollo de la enfermedad ateroscler\u00f3tica oclusiva severa de la aorta (aoa).  material y m\u00e9todos: estudio de asociaci\u00f3n gen\u00e9tica entre 104 pacientes con aoa y 578 controles, analiz\u00e1ndose los siguientes polimorfismos: mol\u00e9culas de histocompatibilidad clase ii; microsat\u00e9lites tnfa y tnfb del promotor del gen tnf; microsat\u00e9lites il-10r, il-10g, (il10) -1082a\/g, (il10) -592c\/a, (il10) -819 t\/c del promotor del gen il10; microsat\u00e9lite (ca )n del promotor del gen mmp9 . resultados: encontramos que el haplotipo ancestral ah60.1 (tnfa11b4-hladrb1*0404) se comportaba como marcador de riesgo de aoa (or:5.92 (ic95  1.82-19.5), p=0.0013). Tambi\u00e9n se comportaba como marcador de riesgo de aoa el haplotipo il-10g11-gcc (or:2.12 (ic95  1.2-3.6), p=0.003). conclusiones: los hallazgos encontrados en cuanto a las asociaciones con el haplotipo ancestral 60.1 por una parte y los alelos del microsat\u00e9lite il10-g y polimorfismos del promotor del ge n il10 apoyan la teor\u00eda inflamatoria de la ateroscler\u00f3tica y el papel de los mecanismos autoinmunitarios en el desarrollo de la enfermedad.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Perfil gen\u00e9tico proinflamatorio en pacientes con enfermedad oclusiva severa de aorta abdominal<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Perfil gen\u00e9tico proinflamatorio en pacientes con enfermedad oclusiva severa de aorta abdominal <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Estrella Blanco Ca\u00f1ibano <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/07\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Javier Serrano  Hernando<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio  jose Torres Garc\u00eda <\/li>\n<li>eduardo Ros die (vocal)<\/li>\n<li>Miguel Fern\u00e1ndez arquero (vocal)<\/li>\n<li>Francisco Lozano sanchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Estrella Blanco Ca\u00f1ibano Introducci\u00f3n: la reacci\u00f3n inflamatoria es responsable del desarrollo y progresi\u00f3n de la aterosclerosis. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[15009,1555,44184,9873,145038,14600],"class_list":["post-65785","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-antonio-jose-torres-garcia","tag-eduardo-ros-die","tag-francisco-javier-serrano-hernando","tag-francisco-lozano-sanchez","tag-maria-estrella-blanco-canibano","tag-miguel-fernandez-arquero"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/65785","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=65785"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/65785\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=65785"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=65785"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=65785"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}