{"id":65909,"date":"2008-04-07T00:00:00","date_gmt":"2008-04-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/control-de-la-proliferacion-celular-por-cannabinoides-en-cancer-de-mama\/"},"modified":"2008-04-07T00:00:00","modified_gmt":"2008-04-07T00:00:00","slug":"control-de-la-proliferacion-celular-por-cannabinoides-en-cancer-de-mama","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/control-de-la-proliferacion-celular-por-cannabinoides-en-cancer-de-mama\/","title":{"rendered":"Control de la proliferaci\u00f3n celular por cannabinoides en c\u00e1ncer de mama."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda Mu\u00f1oz Caffarel <\/strong><\/h2>\n<p>Null los cannabinoides, principios activos de la planta cannabis sativa, se han empleado desde la antig\u00ed\u00bcedad con fines terap\u00e9uticos y recreativos. Hoy en d\u00eda, gracias a la caracterizaci\u00f3n bioqu\u00edmica y farmacol\u00f3gica del sistema endocannabinoide, se ha avan zado mucho en el avance del estudio de las acciones de estos compuestos. Una de las posibles aplicaciones terap\u00e9uticas de los cannabinoides que est\u00e1 m\u00e1s en boga es su papel como posibles agentes antitumorales, ya que estos compuestos reducen la proli feraci\u00f3n de un gran n\u00famero de l\u00edneas tumorales en cultivo y su efecto ha sido confirmado en modelos animales de carcinomas de pulm\u00f3n, p\u00e1ncreas, piel y mama, as\u00ed como en gliomas, epiteliomas de tiroide y melanomas. Los cannabinoides pueden ejercer su acci\u00f3n antitumoral a trav\u00e9s de varios mecanismos entre los que se incluyen la inhibici\u00f3n de la proliferaci\u00f3n y la inducci\u00f3n de la muerte por apoptosis de las c\u00e9lulas tumorales, la inducci\u00f3n de la diferenciaci\u00f3n de las c\u00e9lulas troncales tumorales y la  inhibici\u00f3n de la angiog\u00e9nesis y la met\u00e1stasis tumoral. Mientras que el mecanismo por el que los cannabinoides inducen la apoptosis de las c\u00e9lulas tumorales est\u00e1 bastante bien caracterizado, se sabe muy poco de c\u00f3mo estos compuestos controlan la prol iferaci\u00f3n de estas c\u00e9lulas, y m\u00e1s concretamente, de c\u00f3mo afectan al ciclo celular, proceso clave en el control de la proliferaci\u00f3n celular. En esta tesis doctoral hemos estudiado el mecanismo por el que los cannabinoides controlan la proliferaci\u00f3n de  c\u00e9lulas de c\u00e1ncer de mama y hemos demostrado que \u00e9ste mecanismo implica alteraciones en el ciclo celular. Hemos estudiado tambi\u00e9n el efecto de los cannabinoides en un modelo gen\u00e9tico de c\u00e1ncer de mama, comprobando que dichos compuestos reducen la pr ogresi\u00f3n tumoral. Por \u00faltimo, hemos analizado la expresi\u00f3n de receptores de cannabinoides en una serie de tumores de mama humanos y tejidos sanos de mama y hemos observado que la expresi\u00f3n del receptor de cannabinoides cb2 se correlaciona con la mali gnidad tumoral. Todos estos resultados confirman el potencial de los cannabinoides como posible herramienta terap\u00e9utica para el tratamiento del c\u00e1ncer de mama.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Control de la proliferaci\u00f3n celular por cannabinoides en c\u00e1ncer de mama.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Control de la proliferaci\u00f3n celular por cannabinoides en c\u00e1ncer de mama. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda Mu\u00f1oz Caffarel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/07\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Guzm\u00e1n Pastor<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  lucio Iovanna <\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Mu\u00f1oz Caffarel Null los cannabinoides, principios activos de la planta cannabis sativa, se han empleado desde [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[41091,39707,145288],"class_list":["post-65909","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-juan-lucio-iovanna","tag-manuel-guzman-pastor","tag-maria-munoz-caffarel"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/65909","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=65909"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/65909\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=65909"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=65909"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=65909"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}