{"id":65975,"date":"2008-04-07T00:00:00","date_gmt":"2008-04-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/activacion-macrofagica-peritoneal-asociada-a-la-presencia-de-adn-bacteriano-en-pacientes-con-ciri\/"},"modified":"2008-04-07T00:00:00","modified_gmt":"2008-04-07T00:00:00","slug":"activacion-macrofagica-peritoneal-asociada-a-la-presencia-de-adn-bacteriano-en-pacientes-con-ciri","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-tecnologicas\/activacion-macrofagica-peritoneal-asociada-a-la-presencia-de-adn-bacteriano-en-pacientes-con-ciri\/","title":{"rendered":"Activacion macrofagica peritoneal asociada a la presencia de adn bacteriano en pacientes con ciri"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco Uceda Porta <\/strong><\/h2>\n<p>Las infecciones bacterianas y la gravedad de la respuesta inflamatoria influyen en el pron\u00f3stico de los pacientes con cirrosis avanzada. Se ha comparado la respuesta \u00c2\u00a1inmune innata a la translocaci\u00f3n de aon bacteriano (adnb) con la causada por la (translocaci\u00f3n de bacterias viables en pacientes con peritonitis bacteriana espont\u00e1nea (pbe) y la relaci\u00f3n entre la respuesta de citoquinas y el nivel s\u00e9rico de adnb. La translocaci\u00f3n de adnb se investig\u00f3 en 226 pacientes con cirrosis y ascitis r o infectada, 22 pacientes con pbe y 10 pacientes con scitis que recib\u00edan norfloxacino de forma contin\u00faa. Se midi\u00f3 el factor de necrosis tumoral alfa, el interfer\u00f3n gamma la interleuquina 12 y los metabolitos del \u00f3xido n\u00edtrico. La identificaci\u00f3n del adnb se realiz\u00f3 mediante amplificaci\u00f3n y secuenciaci\u00f3n del rna ribosomal y cuantificaci\u00f3n digital con adn lab-on-ch\u00edps. El adnb estaba presente en 77 pacientes no infectadas (345) y en lodos los casos de pbe, incluso en aquellos casos con cultivo negativo. Ninguno de los pacientes que recib\u00edan norfloxacino mostr\u00f3 translocaci\u00f3n bacteriana. Los nivelas de todas las citoquinas fueron similares en pacientes con translocaci\u00f3n bacteriana del adnb que en aquellas con pbe y significativamente m\u00e1s elevada que en pacientes sin translocaci\u00f3n del adnb o en aquellos que recib\u00edan norfloxac\u00edno la concentraci\u00f3n de adnb s\u00e9rica era paralela a los niveles de todas las citoquinas y del \u00f3xido n\u00edtrico en los pacientes con translocaci\u00f3n del adnb o pbe durante las primeras 72 h. Conclusi\u00f3n: la translocaci\u00f3n del adnb est\u00e1 asociada a una respuesta inflamatoria que es indistinguible de la de los pacientes con pbe y es dependiente de la concentraci\u00f3n de adn. La respuesta de las citoquinas y la tranlocaci\u00f3n de adnb es abolida por el norloxacino<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Activacion macrofagica peritoneal asociada a la presencia de adn bacteriano en pacientes con ciri<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Activacion macrofagica peritoneal asociada a la presencia de adn bacteriano en pacientes con ciri <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco Uceda Porta <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Miguel hern\u00e1ndez de elche<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/07\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Francisco Such Ronda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: agust\u00edn Albillos mart\u00ednez <\/li>\n<li>gloria Royo garcia (vocal)<\/li>\n<li>ricardo Sol\u00ed\u00a0 lamoglia (vocal)<\/li>\n<li>Carlos Sillero garcia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco Uceda Porta Las infecciones bacterianas y la gravedad de la respuesta inflamatoria influyen en el pron\u00f3stico [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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