{"id":66222,"date":"2008-11-07T00:00:00","date_gmt":"2008-11-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-papel-de-las-enzimas-claves-del-ciclo-del-gioxilico-y-del-tansporte-de-acetil-coa-en-la-virulencia-e-aspergillus-fumigatus\/"},"modified":"2008-11-07T00:00:00","modified_gmt":"2008-11-07T00:00:00","slug":"estudio-del-papel-de-las-enzimas-claves-del-ciclo-del-gioxilico-y-del-tansporte-de-acetil-coa-en-la-virulencia-e-aspergillus-fumigatus","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/micologia\/estudio-del-papel-de-las-enzimas-claves-del-ciclo-del-gioxilico-y-del-tansporte-de-acetil-coa-en-la-virulencia-e-aspergillus-fumigatus\/","title":{"rendered":"Estudio del papel de las enzimas claves del ciclo del gioxilico y del tansporte de acetil-coa en la virulencia e aspergillus fumigatus"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Israel Olivas Martinez <\/strong><\/h2>\n<p>Aspergillus fumigatus es un hongo pat\u00f3geno oportunista de humanos que produce aspergilosis invasora (ai) en individuos inmunodeprimidos. Los elevados niveles de incidencia y mortalidad asociados a esta micosis hacen necesaria la b\u00fasqueda de nuevos antif\u00fangicos para tratar a los pacientes infectados. Estudios llevados a cabo en diversos microorganismos pat\u00f3genos han demostrado que el metabolismo de los \u00e1cidos grasos es una fuente importante de factores de virulencia y, en consecuencia, de posibles dianas terap\u00e9uticas frente a las que dise\u00f1ar antif\u00fangicos m\u00e1s eficaces contra la ai. \t en este trabajo se ha estudiado el papel de las enzimas claves del ciclo del gliox\u00edlico, isocitrato liasa (icl) y malato sintetasa (ms), y del transporte de acetil-coa, carnitina acetil transferasa (cat) y carnitina\/acil-carnitina translocasa (cact), en la virulencia de a. Fumigatus. Para ello, se han construido cuatro cepas \u00abknock-out\u00bb para los genes que codifican dichas prote\u00ednas, empleando dos sistemas de transformaci\u00f3n basados en los marcadores auxotr\u00f3ficos pyr-4 de neurospora crassa y sc de aspergillus nidulans. Los estudios de virulencia e histopatol\u00f3gicos realizados en un modelo murino han demostrado la dispensabilidad de ambas rutas metab\u00f3licas para el establecimiento de ai. Por \u00faltimo, se ha analizado, a nivel fisiol\u00f3gico, la capacidad de las cepas \u00c2\u00bficl, \u00c2\u00bfms, \u00c2\u00bfcat y \u00c2\u00bfcact para germinar y crecer en condiciones limitantes en nutrientes. Los resultados obtenidos han demostrado que la utilizaci\u00f3n del glicerol, procedente de los triglic\u00e9ridos y fosfol\u00edpidos de la membrana del fagosoma, les permite a estas cepas escapar de los macr\u00f3fagos y adquirir, en \u00faltima instancia, un fenotipo virulento.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio del papel de las enzimas claves del ciclo del gioxilico y del tansporte de acetil-coa en la virulencia e aspergillus fumigatus<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio del papel de las enzimas claves del ciclo del gioxilico y del tansporte de acetil-coa en la virulencia e aspergillus fumigatus <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Israel Olivas Martinez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/07\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Ram\u00f3n De Lucas Iglesias<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: fernando Laborda rodriguez <\/li>\n<li>Fernando Leal sanchez (vocal)<\/li>\n<li>alfonso Mendoza losana (vocal)<\/li>\n<li>Mar\u00eda Molina mart\u00edn (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Israel Olivas Martinez Aspergillus fumigatus es un hongo pat\u00f3geno oportunista de humanos que produce aspergilosis invasora (ai) [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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