{"id":66224,"date":"2008-11-07T00:00:00","date_gmt":"2008-11-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/inmunoterapia-anti-tumoral-inducida-por-celulas-dendra%c2%adticas-policlonales-en-leucemias-agudas-mieloblasticas\/"},"modified":"2008-11-07T00:00:00","modified_gmt":"2008-11-07T00:00:00","slug":"inmunoterapia-anti-tumoral-inducida-por-celulas-dendra%c2%adticas-policlonales-en-leucemias-agudas-mieloblasticas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/polipeptidos-y-proteinas\/inmunoterapia-anti-tumoral-inducida-por-celulas-dendra%c2%adticas-policlonales-en-leucemias-agudas-mieloblasticas\/","title":{"rendered":"Inmunoterapia anti-tumoral inducida por c\u00e9lulas dendr\u00edticas policlonales en leucemias agudas mielobl\u00e1sticas"},"content":{"rendered":"

Tesis doctoral de Juan a Serrano L\u00f3pez <\/strong><\/h2>\n

Los pacientes afectos de lam precisan modalidades intensivas de quimioterapia para alcanzar la remisi\u00f3n completa y posteriormente procedimiento de trasplante precursores hematopoy\u00e9ticos aut\u00f3logo (auto-tph) en los pacientes de bajo riesgo. La principal causa de fallo de tratamiento del auto-tph es la reca\u00edda leuc\u00e9mica. En los \u00faltimos a\u00f1os se est\u00e1n desarrollando nuevos tratamientos de inmunoterapia basada en c\u00e9lulas dendr\u00edticas (cds) para prevenir la reca\u00edda post-auto empleando blastos leuc\u00e9micos que precisan diferenciaci\u00f3n ex vivo en cultivos de 5-7 d\u00edas. En este estudio analizamos los precursores dendr\u00edticos presentes en los ph de pacientes con lam obtenidos para la realizaci\u00f3n del auto-tph como fuente no-leuc\u00e9mica de cds. Empleamos muestras biol\u00f3gicas de los ph de 43 pacientes con lam, 30 movilizados con quimioterapia (qt)+ factor estimulante de colonias-granulocitarias (g-csf) y 13 s\u00f3lo con g-csf. Cuantificamos las poblaciones dendr\u00edticas presentes en el mismo mediante citometr\u00eda de flujo y encontramos un predominio de cds mieloides (pcd1) en los pacientes que recibieron qt+g-csf. Una vez purificadas, demostramos la naturaleza policlonal de las pcd1 mediante biolog\u00eda molecular y fish. Estos pcd1 policlonales fueron pulsadas con lisados de blastos tumorales y maduradas con factor de necrosis-tumoral (tnf-a) transform\u00e1ndose en cd1 maduras (mcd1) son capaces de estimular a los linfocitos t aut\u00f3logos para producir respuestas th1 con capacidad citot\u00f3xicas anti-leuc\u00e9mica significativamente superiores en los linfocitos t estimulados solamente con il-2 (p<0,01). Todos estos hallazgos in vitro permiten dise\u00f1ar un studio pre-cl\u00ednico de inmunoterapia basada en los pcd1 policlonales contenidos en los ph obtenidos para el auto.Tph para intentar prevenir las reca\u00eddas leuc\u00e9micas mediante estimulaci\u00f3n del sistema inmune.\n\n\n\n \n\n\n

Datos acad\u00e9micos de la tesis doctoral \u00abInmunoterapia anti-tumoral inducida por c\u00e9lulas dendr\u00edticas policlonales en leucemias agudas mielobl\u00e1sticas<\/strong>\u00ab<\/h3>\n
    \n
  • T\u00edtulo de la tesis:<\/strong>\u00a0 Inmunoterapia anti-tumoral inducida por c\u00e9lulas dendr\u00edticas policlonales en leucemias agudas mielobl\u00e1sticas <\/li>\n
  • Autor:<\/strong>\u00a0 Juan a Serrano L\u00f3pez <\/li>\n
  • Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n
  • Fecha de lectura de la tesis:<\/strong>\u00a0 11\/07\/2008<\/li>\n<\/ul>\n

     <\/p>\n

    Direcci\u00f3n y tribunal<\/h3>\n
      \n
    • Director de la tesis<\/strong>\n
        \n
      • Antonio Torres G\u00f3mez<\/li>\n<\/ul>\n<\/li>\n
      • Tribunal<\/strong>\n
          \n
        • Presidente del tribunal: rafael Solana lara <\/li>\n
        • Miguel \u00e1ngel Sanz alonso (vocal)<\/li>\n
        • Jos\u00e9 f. Tom\u00e1s mart\u00ednez (vocal)<\/li>\n
        • justo pastor Casta\u00f1o fuentes (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

           <\/p>\n","protected":false},"excerpt":{"rendered":"

          Tesis doctoral de Juan a Serrano L\u00f3pez Los pacientes afectos de lam precisan modalidades intensivas de quimioterapia para alcanzar la […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[973,9399,2820,396,877],"tags":[29697,145951,145950,2021,9706,3760],"class_list":["post-66224","post","type-post","status-publish","format-standard","hentry","category-cordoba","category-cultivo-celular","category-genetica-humana","category-polipeptidos-y-proteinas","category-reumatologia","tag-antonio-torres-gomez","tag-jose-f-tomas-Martinez","tag-juan-a-serrano-lopez","tag-justo-pastor-castano-fuentes","tag-miguel-angel-sanz-alonso","tag-rafael-solana-lara"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/66224","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=66224"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/66224\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=66224"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=66224"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=66224"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}