{"id":66400,"date":"2018-03-09T22:54:43","date_gmt":"2018-03-09T22:54:43","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/relacion-estructura-funcion-en-la-dna-polimerasa-del-bacteriofago-phi29-papel-del-dominio-intermedio-de-la-protea%c2%adna-terminal-en-el-reconocimiento-especa%c2%adfico-de-la-dna-polimerasa\/"},"modified":"2018-03-09T22:54:43","modified_gmt":"2018-03-09T22:54:43","slug":"relacion-estructura-funcion-en-la-dna-polimerasa-del-bacteriofago-phi29-papel-del-dominio-intermedio-de-la-protea%c2%adna-terminal-en-el-reconocimiento-especa%c2%adfico-de-la-dna-polimerasa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/genetica-bioquimica\/relacion-estructura-funcion-en-la-dna-polimerasa-del-bacteriofago-phi29-papel-del-dominio-intermedio-de-la-protea%c2%adna-terminal-en-el-reconocimiento-especa%c2%adfico-de-la-dna-polimerasa\/","title":{"rendered":"Relaci\u00f3n estructura-funci\u00f3n en la dna polimerasa del bacteri\u00f3fago phi29. papel del dominio intermedio de la prote\u00edna terminal en el reconocimiento espec\u00edfico de la dna polimerasa"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Patricia P\u00e9rez Arn\u00e1iz <\/strong><\/h2>\n<p>El trabajo desarrollado ha permitido identificar y caracterizar funcionalmente una serie de residuos que act\u00faan como ligandos de dna en los centros activos de exonucle\u00f3lisis y polimerizaci\u00f3n, siendo importantes para la uni\u00f3n y estabilizaci\u00f3n de la cadena iniciadora del d\u00faplex dna en ambos centros activos. Los residuos implicados en la estabilizaci\u00f3n de un ssdna en el centro activo de exonucle\u00f3lisis son tambi\u00e9n importantes para el mantenimiento de la fidelidad de s\u00edntesis. se propone tambi\u00e9n un papel para el subdominio thumb de la dna polimerasa en la coordinaci\u00f3n de las actividades de s\u00edntesis y degradaci\u00f3n. El estudio de residuos evolutivamente conservados en el centro activo de polimerizaci\u00f3n de las dna polimerasas de tipo eucari\u00f3tico ha permitido identificar dos nuevos ligandos de metal en dicho centro activo. mediante la construcci\u00f3n de prote\u00ednas quim\u00e9ricas de las prote\u00ednas terminales de phi29 y del bacteri\u00f3fago relacionado ga-1, se propuso al dominio intermedio de la prote\u00edna terminal como el responsable del reconocimiento espec\u00edfico de la dna polimerasa, a trav\u00e9s de la regi\u00f3n trp-1 de \u00e9sta. Esta interacci\u00f3n es necesaria para que el dominio iniciador de la prote\u00edna terminal se sit\u00fae en el centro activo de polimerizaci\u00f3n de la dna polimerasa de manera catal\u00edticamente competente.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Relaci\u00f3n estructura-funci\u00f3n en la dna polimerasa del bacteri\u00f3fago phi29. papel del dominio intermedio de la prote\u00edna terminal en el reconocimiento espec\u00edfico de la dna polimerasa<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Relaci\u00f3n estructura-funci\u00f3n en la dna polimerasa del bacteri\u00f3fago phi29. papel del dominio intermedio de la prote\u00edna terminal en el reconocimiento espec\u00edfico de la dna polimerasa <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Patricia P\u00e9rez Arn\u00e1iz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/07\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel De Vega Jos\u00e9<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Fernandez piqueras <\/li>\n<li>Antonio Bernad miana (vocal)<\/li>\n<li>Mar\u00eda antonia Blasco marhuenda (vocal)<\/li>\n<li>Luis Blaco d\u00e1vila (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Patricia P\u00e9rez Arn\u00e1iz El trabajo desarrollado ha permitido identificar y caracterizar funcionalmente una serie de residuos que [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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