{"id":66475,"date":"2018-03-09T22:54:47","date_gmt":"2018-03-09T22:54:47","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estres-oxidativo-en-el-glaucoma-primario-de-angulo-abierto-prevencion-de-la-ceguera-por-glaucoma\/"},"modified":"2018-03-09T22:54:47","modified_gmt":"2018-03-09T22:54:47","slug":"estres-oxidativo-en-el-glaucoma-primario-de-angulo-abierto-prevencion-de-la-ceguera-por-glaucoma","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica-molecular\/estres-oxidativo-en-el-glaucoma-primario-de-angulo-abierto-prevencion-de-la-ceguera-por-glaucoma\/","title":{"rendered":"Estr\u00e9s oxidativo en el glaucoma primario de \u00e1ngulo abierto. prevenci\u00f3n de la ceguera por glaucoma"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Vicente Zan\u00f3n Moreno <\/strong><\/h2>\n<p>Con este estudio pretendemos demostrar que los mecanismos de estr\u00e9s oxidativo y nitrosativo est\u00e1n relacionados con el gpaa, y que los neurotransmisores est\u00e1n implicados en las se\u00f1ales que relacionan la hipertensi\u00f3n ocular (hto) con la muerte por apoptosis de las c\u00e9lulas ganglionares de la retina y la p\u00e9rdida subsecuente de las fibras del nervio \u00f3ptico, lo que conduce a la atrofia \u00f3ptica y a la ceguera glaucomatosa. El estudio lo realizaremos en muestras de humor acuoso y plasma de sujetos con glaucoma primario de \u00e1ngulo abierto y sujetos con cataratas no patol\u00f3gicas (grupo comparativo). evaluaremos el estr\u00e9s oxidativo mediante la determinaci\u00f3n del malonildialdeh\u00eddo (producto de la peroxidaci\u00f3n lip\u00eddica), la determinaci\u00f3n de la actividad antioxidante de las enzimas super\u00f3xido dismutasa y glutati\u00f3n peroxidasa y la determinaci\u00f3n del estado antioxidante total. El estr\u00e9s nitrosativo lo evaluaremos mediante la determinaci\u00f3n de la concentraci\u00f3n total de \u00f3xido n\u00edtrico. Los niveles de serotonina y su principal metabolito (\u00e1cido 5-hidroxiindolac\u00e9tico) los determinaremos por hplc. La expresi\u00f3n de la prote\u00edna poli (adp-ribosa) polimerasa-1 la determinaremos mediante western blot e immunoblotting. hemos demostrado un aumento del estr\u00e9s oxidativo y del estr\u00e9s nitrosativo en el glaucoma primario de \u00e1ngulo abierto frente a las cataratas. La serotonina y su metabolito act\u00faan facilitando la alteraci\u00f3n de la homeostasis del humor acuoso en pacientes con glaucoma, permitiendo el aumento de la presi\u00f3n intraocular. El aumento de la expresi\u00f3n de la prote\u00edna poli (adp-ribosa) polimerasa-1 demuestra que en el glaucoma se produce un aumento de la muerte por apoptosis de las c\u00e9lulas, tanto de las c\u00e9lulas de la malla trabecular y de las c\u00e9lulas ganglionares de la retina.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estr\u00e9s oxidativo en el glaucoma primario de \u00e1ngulo abierto. prevenci\u00f3n de la ceguera por glaucoma<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estr\u00e9s oxidativo en el glaucoma primario de \u00e1ngulo abierto. prevenci\u00f3n de la ceguera por glaucoma <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Vicente Zan\u00f3n Moreno <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/07\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Dolores Pinazo Dur\u00e1n<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ignacio Vinuesa silva <\/li>\n<li>vicente Andr\u00e9s Garc\u00eda (vocal)<\/li>\n<li>vicente Vila bou (vocal)<\/li>\n<li>pedro Martins de almeida melo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Vicente Zan\u00f3n Moreno Con este estudio pretendemos demostrar que los mecanismos de estr\u00e9s oxidativo y nitrosativo est\u00e1n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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