{"id":66566,"date":"2018-03-09T22:54:56","date_gmt":"2018-03-09T22:54:56","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/diarrea-va%c2%adrica-bovina-estudio-estructural-ultraestructural-e-inmunohistoqua%c2%adico-de-los-macrofagos-asociados-a-la-va%c2%ada-oronasal-y-en-pulmon\/"},"modified":"2018-03-09T22:54:56","modified_gmt":"2018-03-09T22:54:56","slug":"diarrea-va%c2%adrica-bovina-estudio-estructural-ultraestructural-e-inmunohistoqua%c2%adico-de-los-macrofagos-asociados-a-la-va%c2%ada-oronasal-y-en-pulmon","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/histopatologia\/diarrea-va%c2%adrica-bovina-estudio-estructural-ultraestructural-e-inmunohistoqua%c2%adico-de-los-macrofagos-asociados-a-la-va%c2%ada-oronasal-y-en-pulmon\/","title":{"rendered":"Diarrea v\u00edrica bovina: estudio estructural, ultraestructural e inmunohistoqu\u00edico de los macr\u00f3fagos asociados a la v\u00edaoronasal y en pulm\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Antonio  Da Silva Alexandre <\/strong><\/h2>\n<p>El objetivo de este trabajo fue caracterizar las lesiones y la distribuci\u00f3n de ant\u00edgeno en la tonsila y el pulm\u00f3n de terneros no encalostrados e inoculados con la cepa no citop\u00e1tica 7443 del virus de la diarrea v\u00edrica bovina (dvb), y determinar la relaci\u00f3n espacial y temporal sobre la depleci\u00f3n linfoide, macr\u00f3fagos expresando citoquinas, cambios cuantitativos de los linfocitos t, as\u00ed como el papel de la red estromal (c\u00e9lulas dendr\u00edticas y reticulares). los resultados obtenidos sugieren que la acci\u00f3n directa del virus y de las citoquinas liberadas por los macr\u00f3fagos en fol\u00edculos y \u00e1reas interfoliculares de la tonsila, jugar\u00edan un papel secundario en la apoptosis linfocitaria. La infecci\u00f3n v\u00edrica de las c\u00e9lulas dendr\u00edticas y reticulares inducir\u00eda cambios morfol\u00f3gicos que podr\u00edan alterar los procesos de presentaci\u00f3n de ant\u00edgeno provocando la apoptosis de los linfocitos b. el estudio de la expresi\u00f3n de citoquinas proinflamatorias por los mips y maps de pulm\u00f3n no mostr\u00f3 cambios significativos en el n\u00famero de c\u00e9lulas reactivas frente al tnf a, il-1 a e il-6. As\u00edmismo, pese a la presencia de c\u00e9lulas con signos de infecci\u00f3n v\u00edrica desde los 3 dpi, el n\u00famero de linfocitos t cd3+ cuantificados a nivel intersticial no mostr\u00f3 cambios en fases iniciales de la enfermedad, destacando adem\u00e1s un descenso significativo en el n\u00famero del infocitos t cd4+m cd8+ y ?D+. Por tanto, las funciones de control del virus que pueden ejercer los linfocitos t, as\u00ed como la respuesta inmune, parecen estar inhibidas desde la llegada del vdvb. Se pone as\u00ed de manifiesto as\u00ed el car\u00e1cter inmunosupresor del vdvb que puede predisponer la aparici\u00f3n de agentes secundarios.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Diarrea v\u00edrica bovina: estudio estructural, ultraestructural e inmunohistoqu\u00edico de los macr\u00f3fagos asociados a la v\u00edaoronasal y en pulm\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Diarrea v\u00edrica bovina: estudio estructural, ultraestructural e inmunohistoqu\u00edico de los macr\u00f3fagos asociados a la v\u00edaoronasal y en pulm\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Antonio  Da Silva Alexandre <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/07\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pedro Jose Sanchez Cordon<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alfonso Blanco rodriguez <\/li>\n<li>Mar\u00eda carmen Tarradas iglesias (vocal)<\/li>\n<li>Mar\u00eda Jos\u00e9 Bautista p\u00e9rez (vocal)<\/li>\n<li>anabela gouveia Antunes alves (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Antonio Da Silva Alexandre El objetivo de este trabajo fue caracterizar las lesiones y la distribuci\u00f3n de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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