{"id":66590,"date":"2018-03-09T22:54:56","date_gmt":"2018-03-09T22:54:56","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicaciones-de-smc2-en-la-tumorogenesis-colorrectal-una-nueva-diana-de-la-via-de-senalizacion-wnt-beta-catenina\/"},"modified":"2018-03-09T22:54:56","modified_gmt":"2018-03-09T22:54:56","slug":"implicaciones-de-smc2-en-la-tumorogenesis-colorrectal-una-nueva-diana-de-la-via-de-senalizacion-wnt-beta-catenina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/implicaciones-de-smc2-en-la-tumorogenesis-colorrectal-una-nueva-diana-de-la-via-de-senalizacion-wnt-beta-catenina\/","title":{"rendered":"Implicaciones de smc2 en la tumorogenesis colorrectal: una nueva diana de la via de se\u00f1alizacion wnt\/beta-catenina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Veronica Davalos Vega <\/strong><\/h2>\n<p>La prote\u00edna smc2 (structural maintenance of chromosomes 2) forma parte del complejo condensina, implicado en la compactaci\u00f3n de la cromatina y la formaci\u00f3n de cromosomas mit\u00f3ticos. Adem\u00e1s, estudios en organismos modelo han demostrado su funci\u00f3n en la regulaci\u00f3n de la expresi\u00f3n g\u00e9nica, aunque hasta el momento esto no hab\u00eda sido evaluado en el caso de humanos. Los datos presentados en este estudio constituyen la primera evidencia de la implicaci\u00f3n de smc2 en c\u00e1ncer, particularmente en c\u00e1ncer colorrectal (ccr). Smc2 est\u00e1 sobrexpresado en el 90% de los casos de ccr estudiados, independientemente de los antecedentes clinicopatol\u00f3gicos.  nuestros resultados demuestran que la v\u00eda de se\u00f1alizaci\u00f3n wnt\/beta-catenina es uno de los mecanismos moleculares responsables de la regulaci\u00f3n transcripcional de smc2. El promotor de smc2 posee un sitio funcional de uni\u00f3n para tcf4, que est\u00e1 conservado en mam\u00edferos. La inhibici\u00f3n de tcf4 o beta-catenina en modelos celulares conlleva a la reducci\u00f3n de la expresi\u00f3n de smc2. Considerando que la activaci\u00f3n aberrante de la v\u00eda wnt ocurre en el 85-90% de casos de ccr, sugerimos que esto podr\u00eda explicar la sobrexpresi\u00f3n de smc2 detectada en este tipo de c\u00e1ncer.  tambi\u00e9n hemos detectado que la sobrexpresi\u00f3n ect\u00f3pica de smc2 en l\u00edneas celulares de ccr aumenta su potencial clonog\u00e9nico, mientras que la inhibici\u00f3n de la expresi\u00f3n de smc2 disminuye el crecimiento de los tumores en modelos murinos de xenotransplante, lo que sugiere una implicaci\u00f3n de smc2 en la tumorog\u00e9nesis colorrectal.   smc2 se asocia a un entorno transcripcionalmente inactivo en los promotores y su inhibici\u00f3n conlleva a un incremento en la expresi\u00f3n de genes antitumorales. La sobrexpresi\u00f3n de smc2 en ccr podr\u00eda contribuir a la tumorog\u00e9nesis a trav\u00e9s del silenciamiento de genes supresores de tumores, anti-proliferativos, anti-metast\u00e1sicos y pro-apopt\u00f3ticos, mediante mecanismos asociados a la formaci\u00f3n de complejos de represi\u00f3n transcripcional.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicaciones de smc2 en la tumorogenesis colorrectal: una nueva diana de la via de se\u00f1alizacion wnt\/beta-catenina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicaciones de smc2 en la tumorogenesis colorrectal: una nueva diana de la via de se\u00f1alizacion wnt\/beta-catenina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Veronica Davalos Vega <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/07\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Simo Schwartz Navarro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: mireia Du\u00f1ach masJuan <\/li>\n<li>bru Cormand (vocal)<\/li>\n<li>anna Messeguer navarro (vocal)<\/li>\n<li>Miguel angel Peinado morales (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Veronica Davalos Vega La prote\u00edna smc2 (structural maintenance of chromosomes 2) forma parte del complejo condensina, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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