{"id":66712,"date":"2018-03-09T22:55:04","date_gmt":"2018-03-09T22:55:04","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/deteccion-de-papiloma-virus-humano-y-expresion-de-genes-supresores-tumorales-p16-y-p53-en-carcinomas-de-region-genital-externa\/"},"modified":"2018-03-09T22:55:04","modified_gmt":"2018-03-09T22:55:04","slug":"deteccion-de-papiloma-virus-humano-y-expresion-de-genes-supresores-tumorales-p16-y-p53-en-carcinomas-de-region-genital-externa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/patologia-clinica\/deteccion-de-papiloma-virus-humano-y-expresion-de-genes-supresores-tumorales-p16-y-p53-en-carcinomas-de-region-genital-externa\/","title":{"rendered":"Detecci\u00f3n de papiloma virus humano y expresi\u00f3n de genes supresores tumorales p16 y p53 en carcinomas de regi\u00f3n genital externa"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Manuel God\u00ednez Mart\u00ednez <\/strong><\/h2>\n<p>La implicaci\u00f3n del papilomavirus humano (hpv) en la carcinog\u00e9nesis de c\u00e9rvix est\u00e1 totalmente demostrada, pero esta infecci\u00f3n se puede producir en otras regiones anat\u00f3micas con similares consecuencias patol\u00f3gicas. El estudio presenta la detecci\u00f3n de hpv en carcinomas de pene y vulva mediante t\u00e9cnicas de reacci\u00f3n en cadena de la polimerasa (pcr), analizando la sensibilidad de diferentes sets de primers, el set gp5+\/6+ y el set my09\/11. Tambi\u00e9n se lleva a cabo la detecci\u00f3n inmunohistoqu\u00edmica de prote\u00ednas celulares como posibles marcadores diagn\u00f3stico de la infeccci\u00f3n por hpv, las prote\u00ednas reguladoras del ciclo celular p53 y p16. La expresi\u00f3n de estas prote\u00ednas se ve supuestamente alterada a trav\u00e9s de la infecci\u00f3n por hpv. Los resultados aportados por el estudio muestran c\u00f3mo en la poblaci\u00f3n de estudio existe una incidencia inusualmente alta de hpv en carcinomas de pene (cercana al 77,5 %), mientras que en el caso de los carcinomas de vulva la tasa de detecci\u00f3n de hpv se encuentra dentro de los rangos esperarados seg\u00fan los trabajos anteriormente realizados en esta materia (29,7%). El tratamiento estad\u00edstico realizado para comprobar si existe relaci\u00f3n entre la presencia de hpv y la expresi\u00f3n de los marcadores celulares nos da como resultado la no asociaci\u00f3n de estos marcadores con la infecci\u00f3n por hpv en las patolog\u00edas estudiadas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Detecci\u00f3n de papiloma virus humano y expresi\u00f3n de genes supresores tumorales p16 y p53 en carcinomas de regi\u00f3n genital externa<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Detecci\u00f3n de papiloma virus humano y expresi\u00f3n de genes supresores tumorales p16 y p53 en carcinomas de regi\u00f3n genital externa <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Manuel God\u00ednez Mart\u00ednez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/07\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Enrique Poblet Martinez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 manuel Juiz g\u00f3mez <\/li>\n<li>alejandro Pascual mart\u00edn (vocal)<\/li>\n<li>Francisco Jos\u00e9 Saez crespo (vocal)<\/li>\n<li>Juan  Mar\u00eda Vazquez rojas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Manuel God\u00ednez Mart\u00ednez La implicaci\u00f3n del papilomavirus humano (hpv) en la carcinog\u00e9nesis de c\u00e9rvix est\u00e1 totalmente [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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