{"id":66770,"date":"2008-05-09T00:00:00","date_gmt":"2008-05-09T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/factor-de-crecimiento-endotelial-vascular-en-la-maduracion-pulmonar-en-ratas-tratadas-con-corticoides-prenatales-sometidas-a-hipoxia-y-recuperadas-con-aire-o-hiperoxia\/"},"modified":"2008-05-09T00:00:00","modified_gmt":"2008-05-09T00:00:00","slug":"factor-de-crecimiento-endotelial-vascular-en-la-maduracion-pulmonar-en-ratas-tratadas-con-corticoides-prenatales-sometidas-a-hipoxia-y-recuperadas-con-aire-o-hiperoxia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/pediatria\/factor-de-crecimiento-endotelial-vascular-en-la-maduracion-pulmonar-en-ratas-tratadas-con-corticoides-prenatales-sometidas-a-hipoxia-y-recuperadas-con-aire-o-hiperoxia\/","title":{"rendered":"Factor de crecimiento endotelial vascular en la maduraci\u00f3n pulmonar en ratas tratadas con corticoides prenatales sometidas a hipoxia y recuperadas con aire o hiperoxia."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Bel\u00e9n Remesal Escalero <\/strong><\/h2>\n<p>El uso de glucocorticoides prenatales es una pr\u00e1ctica cl\u00ednica frecuente y es importante conocer su efecto sobre el factor de crecimiento endotelial vascular (vegf) en el pulm\u00f3n, debido al papel que tiene este factor de crecimiento en el desarrollo pulmonar. El objetivo de este estudio fue comparar la expresi\u00f3n del vegf pulmonar en ratas reci\u00e9n nacidas que fueron expuestas a betametasona prenatal, dexametasona prenatal o placebo (control) en condiciones basales y despu\u00e9s de la exposici\u00f3n a la hipoxia aguda y su recuperaci\u00f3n con aire o hiperoxia en el momento del nacimiento. se evalu\u00f3 la expresi\u00f3n del vegf, al nacimiento y a los 4 y 14 d\u00edas postnatales, la expresi\u00f3n proteica por inmunohistoqu\u00edmica  y la expresi\u00f3n del arnm mediante rt-pcr (reacci\u00f3n en cadena de la polimerasa por transcripci\u00f3n inversa). La cuantificaci\u00f3n de la prote\u00edna y del arnm del vegf se realiz\u00f3 mediante densitometr\u00eda con el programa de procesamiento de imagen  imagej. conclusiones. La exposici\u00f3n a hipoxia aguda incrementa la expresi\u00f3n proteica del vegf pulmonar; la recuperaci\u00f3n con hiperoxia aguda produce un descenso en la expresi\u00f3n del vegf pulmonar que se mantiene durante todo el estudio. La dexametasona disminuye la expresi\u00f3n del vegf pulmonar al nacimiento y al d\u00eda 4 de betametasona antenatal se asocia con un incremento en la expresi\u00f3n del postnatal, fase de mayor desarrollo vascular e inicio de la alveolizaci\u00f3n en el pulm\u00f3n de rata. La dexametasona disminuye el efecto de inducci\u00f3n del vegf por la hipoxia y tiene un efecto aditivo con la hiperoxia en la inhibici\u00f3n del vegf pulmonar. La administraci\u00f3n vegf pulmonar y tiene un efecto aditivo con la hipoxia en la inducci\u00f3n del vegf pulmonar. La administraci\u00f3n de betametasona prenatal aumenta la expresi\u00f3n del vegf pulmonar en todas las situaciones experimentales comparada con la dexametasona prenatal. nuestros resultados apoyar\u00edan que la betametasona podr\u00eda ser la mejor elecci\u00f3n para tratar a mujeres gestantes con riesgo de parto pret\u00e9rmino.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Factor de crecimiento endotelial vascular en la maduraci\u00f3n pulmonar en ratas tratadas con corticoides prenatales sometidas a hipoxia y recuperadas con aire o hiperoxia.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Factor de crecimiento endotelial vascular en la maduraci\u00f3n pulmonar en ratas tratadas con corticoides prenatales sometidas a hipoxia y recuperadas con aire o hiperoxia. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Bel\u00e9n Remesal Escalero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/09\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carmen Pedraz Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: valentin Salazar villalobos <\/li>\n<li>adolf Valls soler (vocal)<\/li>\n<li>josep Figueras aloy (vocal)<\/li>\n<li>Juan a Guzman caba\u00f1as (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Bel\u00e9n Remesal Escalero El uso de glucocorticoides prenatales es una pr\u00e1ctica cl\u00ednica frecuente y es importante [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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