{"id":66776,"date":"2008-05-09T00:00:00","date_gmt":"2008-05-09T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-celulares-y-moleculares-de-la-patologa%c2%ada-vascular-de-la-dirofilariosis-cardiopulmonar-el-papel-de-las-filarias-y-de-los-endosimbiontes-del-genero-wolbachia\/"},"modified":"2008-05-09T00:00:00","modified_gmt":"2008-05-09T00:00:00","slug":"mecanismos-celulares-y-moleculares-de-la-patologa%c2%ada-vascular-de-la-dirofilariosis-cardiopulmonar-el-papel-de-las-filarias-y-de-los-endosimbiontes-del-genero-wolbachia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/enfermedades-pulmonares\/mecanismos-celulares-y-moleculares-de-la-patologa%c2%ada-vascular-de-la-dirofilariosis-cardiopulmonar-el-papel-de-las-filarias-y-de-los-endosimbiontes-del-genero-wolbachia\/","title":{"rendered":"Mecanismos celulares y moleculares de la patolog\u00eda vascular de la dirofilariosis cardiopulmonar. el papel de las filarias y de los endosimbiontes del g\u00e9nero \u00abwolbachia\u00bb"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rodrigo Morch\u00f3n Garc\u00eda <\/strong><\/h2>\n<p>Dirofilaria immitis es el agente causante de la dirofilariosis cardiopulmonar canina y felina y la dirofilariosis pulmonar humana. Como otras filarias, este par\u00e1sito alberga bacterias endosimbiontes del g\u00e9nero wolbachia. La dirofilariosis cardiopulmonar animal es una enfermedad cr\u00f3nica. Produce da\u00f1os endoteliales, despu\u00e9s pulmonares, y en sus \u00faltimas fases puede verse afectado el coraz\u00f3n. La muerte masiva de muchos vermes exacerba las reacciones inflamatorias en las arterias pulmonares. Nuestro objetivo fue identificar la presencia de eicosanoides en hospedadores infectados con d. Immitis y sus cambios a lo largo de la infecci\u00f3n, y dise\u00f1ar un modelo experimental basado en el cultivo in vitro de c\u00e9lulas endoteliales vasculares para estudiar el efecto del extracto antig\u00e9nico de adultos de d. Immitis (disa) y el de la prote\u00edna mayoritaria de la cubierta de wolbachia recombinante (wspr) sobre los mecanismos celulares y moleculares del endotelio vascular en la dirofilariosis cardiopulmonar durante la patolog\u00eda aguda. En hospedadores animales y humanos con dirofilariosis cr\u00f3nica se detectan altas concentraciones de txb2 y ltb4, pero no de pge2. En gatos infectados experimentalmente, la concentraci\u00f3n de todos ellos es similar a la observada en infecciones naturales cr\u00f3nicas a los 6 meses postinfecci\u00f3n. La muerte temprana de las larvas inducida por el tratamiento con ivermectina altera el patr\u00f3n evolutivo de pge2 y ltb4 pero no del txb2. Esto podr\u00eda estar relacionado con la disminuci\u00f3n de la gravedad de las reacciones inflamatorias, una vez que las larvas son eliminadas. Disa y wspr estimulan selectivamente mol\u00e9culas directamente relacionadas con el proceso inflamatorio en c\u00e9lulas endoteliales durante las primeras 24 horas de tratamiento, sin alterar los procesos fisiol\u00f3gicos b\u00e1sicos de dichas c\u00e9lulas. Disa est\u00e1 relacionado con los procesos de vasodilataci\u00f3n y disminuci\u00f3n de la permeabilidad vascular, lo que podr\u00eda facilitar la supervivencia del par\u00e1sito y wspr parece estar relacionado con el proceso de reclutamiento de c\u00e9lulas inmunitarias.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos celulares y moleculares de la patolog\u00eda vascular de la dirofilariosis cardiopulmonar. el papel de las filarias y de los endosimbiontes del g\u00e9nero \u00abwolbachia\u00bb<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos celulares y moleculares de la patolog\u00eda vascular de la dirofilariosis cardiopulmonar. el papel de las filarias y de los endosimbiontes del g\u00e9nero \u00abwolbachia\u00bb <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rodrigo Morch\u00f3n Garc\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/09\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fernando Sim\u00f3n Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Santiago Mas coma <\/li>\n<li>Alberto Montoya alonso (vocal)<\/li>\n<li>claudio Genchi (vocal)<\/li>\n<li>Francisco Bolas fernandez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rodrigo Morch\u00f3n Garc\u00eda Dirofilaria immitis es el agente causante de la dirofilariosis cardiopulmonar canina y felina y 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