{"id":66778,"date":"2008-05-09T00:00:00","date_gmt":"2008-05-09T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-las-b-1-3-transferasas-de-la-familia-gh72-implicadas-en-la-remodelacion-de-la-pared-celular-de-schizosaccharomyces-pombe\/"},"modified":"2008-05-09T00:00:00","modified_gmt":"2008-05-09T00:00:00","slug":"caracterizacion-de-las-b-1-3-transferasas-de-la-familia-gh72-implicadas-en-la-remodelacion-de-la-pared-celular-de-schizosaccharomyces-pombe","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/levaduras\/caracterizacion-de-las-b-1-3-transferasas-de-la-familia-gh72-implicadas-en-la-remodelacion-de-la-pared-celular-de-schizosaccharomyces-pombe\/","title":{"rendered":"Caracterizaci\u00f3n de las b-1, 3-transferasas de la familia gh72 implicadas en la remodelaci\u00f3n de la pared celular de schizosaccharomyces pombe"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda De Medina Redondo <\/strong><\/h2>\n<p>La formaci\u00f3n de la pared celular de schizosaccharomyces pombe requiere la actividad coordinada de enzimas involucradas en la bios\u00edntesis y modificaci\u00f3n de sus componentes, entre los que destacan por su abundancia los glucanos. El complejo enzim\u00e1tico \u00edY-gluc\u00e1n-sintasa sintetiza \u00edY-1,3-glucanos lineales, que permanecen desorganizados y solubles en \u00e1lcali hasta que se establecen enlaces covalentes entre los \u00edY-1,3-glucanos y otros componentes de la pared celular. Las transferasas de la pared celular cuyos sustratos son los \u00edY-1,3-glucanos podr\u00edan estar desempe\u00f1ando importantes funciones en el ensamblaje y reordenamiento de la pared celular. Diversas prote\u00ednas pertenecientes a la familia 72 de las glicosil-hidrolasas (gh72) con actividad \u00edY-1,3-glucanosil-transferasa han sido caracterizadas en otros organismos (gas1p, gas2p y gas4p de saccharomyces cerevisiae, o gel1p de aspergillus fumigatus). La secuenciaci\u00f3n del genoma de s. Pombe ha permitido identificar cuatro genes (gas1+, gas2+, gas4+ y gas5+) que codifican cuatro hipot\u00e9ticas prote\u00ednas pertenecientes a la familia gh72. desde el punto de vista funcional, gas1p es esencial para la viabilidad celular durante el crecimiento vegetativo, ya que los mutantes carentes de este gen s\u00f3lo son capaces de crecer en medios estabilizados osm\u00f3ticamente. Por su parte, gas4p desempe\u00f1a un papel b\u00e1sico en la construcci\u00f3n de la pared celular de las esporas. Finalmente, las prote\u00ednas gas2p y gas5p deben ejercer un papel minoritario en la s\u00edntesis de la pared celular vegetativa, ya que mutantes carentes de estos genes (o el doble mutante) no presentan defectos morfol\u00f3gicos significativos. bioqu\u00edmicamente, todas ellas poseen actividad \u00edY-1,3-glucanosil-transferasa, aunque se diferencian por la especificidad de longitud de sustrato, el punto de corte y los productos generados. Todo ello, junto con las diferencias de expresi\u00f3n a lo largo del ciclo biol\u00f3gico, sugiere que las distintas prote\u00ednas de la familia gh72 presentes en s. Pombe podr\u00edan estar realizando funciones complementarias, no solapantes, en la levadura de fisi\u00f3n.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n de las b-1, 3-transferasas de la familia gh72 implicadas en la remodelaci\u00f3n de la pared celular de schizosaccharomyces pombe<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n de las b-1, 3-transferasas de la familia gh72 implicadas en la remodelaci\u00f3n de la pared celular de schizosaccharomyces pombe <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda De Medina Redondo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/09\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Rey Iglesias<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  isabel Gonzalez roncero <\/li>\n<li>ram\u00f3n Santamar\u00eda s\u00e1nchez (vocal)<\/li>\n<li>thierry Fontaine (vocal)<\/li>\n<li>Javier Arroyo nombela (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda De Medina Redondo La formaci\u00f3n de la pared celular de schizosaccharomyces pombe requiere la actividad coordinada [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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