{"id":66783,"date":"2008-05-09T00:00:00","date_gmt":"2008-05-09T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/resistencia-a-macrolidos-en-estreptococos-viridans-epidemiologa%c2%ada-y-estudio-molecular\/"},"modified":"2008-05-09T00:00:00","modified_gmt":"2008-05-09T00:00:00","slug":"resistencia-a-macrolidos-en-estreptococos-viridans-epidemiologa%c2%ada-y-estudio-molecular","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/microbiologia\/resistencia-a-macrolidos-en-estreptococos-viridans-epidemiologa%c2%ada-y-estudio-molecular\/","title":{"rendered":"Resistencia a macr\u00f3lidos en estreptococos \u00abviridans\u00bb. epidemiolog\u00eda y estudio molecular"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda Sagrario Hern\u00e1ndez Iglesias <\/strong><\/h2>\n<p>Se llev\u00f3 a cabo un estudio sobre la preValencia de la resistencia a antimicrobianos del grupo mlsb en estreptococos viridans procedentes de individuos sanos no sometidos a tratamiento antibi\u00f3tico recientemente, los fenotipos de resistencia y los determinantes gen\u00e9ticos implicados en la misma. La preValencia de resistencia a eritromicina fue del 68,9%. Predomin\u00f3 el fenotipo m (80,65%) frente al fenotipo mlsb (19,35%). Todas las cepas con fenotipo m portaban genes mef, en la mayor parte de los casos mefe (94%). Todas las cepas con fenotipo mlsb mostraron este fenotipo de forma constitutiva, y portaban en todos los casos en gen ermb. Un 91.7% de \u00e9stas portaban adem\u00e1s genes mefe, si bien \u00e9ste no influ\u00eda en su fenotipo. Todas las cepas portadoras de gen mefa, inclu\u00edan \u00e9ste dentro de un traspos\u00f3n tn 1207.1, como es habitual en otros estreptococos como s. Pyogenes. Los genes mefe se encontraban inclu\u00eddos en un elemento gen\u00e9tico similar, aunque no id\u00e9ntico, al elemento mega descrito previamente en s. Pneumoniae, que se ha denominado mega-like. Adem\u00e1s, en este estudio se han detectado genes mefe en un 65% de las cepas sensibles, circunstancia no descrita previamente en especie alguna. De las dos variedades de elementos mega descritos en neumococo, todas las cepas de estreptococos viridans resistentes a macr\u00f3lidos portaban la que conserva \u00edntegro el fragmento interg\u00e9nico entre los genes mef y mel, mientras que todas las sensibles eran portadoras de un elemento mega-like que, al igual que una de las variantes del elemento mega, muestra una deleci\u00f3n de 99 pares de bases en el mencionado fragmento interg\u00e9nico. No obstante, la transformaci\u00f3n del dna de estos estreptococos viridans en streptococcus pneumoniae r6 condicion\u00f3, en todos los casos, la aparici\u00f3n de resistencia a macr\u00f3lidos con fenotipo m, incluso cuando el dna proced\u00eda de cepas sensibles, pero portadoras de mef.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Resistencia a macr\u00f3lidos en estreptococos \u00abviridans\u00bb. epidemiolog\u00eda y estudio molecular<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Resistencia a macr\u00f3lidos en estreptococos \u00abviridans\u00bb. epidemiolog\u00eda y estudio molecular <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda Sagrario Hern\u00e1ndez Iglesias <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/09\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Luis Mu\u00f1oz Bellido<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  del carmen S\u00e1enz gonz\u00e1lez <\/li>\n<li>Juan  Jos\u00e9 Picazo de la garza (vocal)<\/li>\n<li>Jos\u00e9 Prieto prieto (vocal)<\/li>\n<li>Antonio  c\u00e1ndido G\u00f3mez Garc\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Sagrario Hern\u00e1ndez Iglesias Se llev\u00f3 a cabo un estudio sobre la preValencia de la resistencia a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[2193,1418,278,597,9386],"tags":[9630,3474,3475,25841,8318,147106],"class_list":["post-66783","post","type-post","status-publish","format-standard","hentry","category-antibioticos","category-bacteriologia","category-microbiologia","category-microbiologia-clinica","category-salamanca","tag-antonio-candido-gomez-garcia","tag-jose-prieto-prieto","tag-juan-jose-picazo-de-la-garza","tag-juan-luis-munoz-bellido","tag-maria-del-carmen-saenz-gonzalez","tag-maria-sagrario-hernandez-iglesias"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/66783","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=66783"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/66783\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=66783"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=66783"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=66783"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}