{"id":66906,"date":"2018-03-09T22:55:15","date_gmt":"2018-03-09T22:55:15","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/recombinacion-genetica-en-vih-1-induccion-de-formas-geneticas-in-vitro-y-su-comparacion-con-las-originadas-in-vivo\/"},"modified":"2018-03-09T22:55:15","modified_gmt":"2018-03-09T22:55:15","slug":"recombinacion-genetica-en-vih-1-induccion-de-formas-geneticas-in-vitro-y-su-comparacion-con-las-originadas-in-vivo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/recombinacion-genetica-en-vih-1-induccion-de-formas-geneticas-in-vitro-y-su-comparacion-con-las-originadas-in-vivo\/","title":{"rendered":"Recombinaci\u00f3n gen\u00e9tica en vih-1: inducci\u00f3n de formas gen\u00e9ticas in vitro y su comparaci\u00f3n con las originadas in vivo."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mercedes Mu\u00f1oz Nieto-sandoval <\/strong><\/h2>\n<p>Hasta el momento actual se han identificado 54 formas gen\u00e9ticas de vih-1, incluyendo 9 subtipos y sub-subtipos, 43 formas recombinantes circulantes y m\u00faltiples formas recombinantes \u00fanicas, lo que apoya la  importancia de las infecciones dobles y que la recombinaci\u00f3n es el principal mecanismo de variaci\u00f3n del vih-1. En esta tesis doctoral se plante\u00f3 que las formas recombinantes pueden tener propiedades biol\u00f3gicas diferentes a sus virus parentales, demostrando la detecci\u00f3n temprana de cepas is\/x4 o is\/x4r5 en pacientes infectados por crf14_bg, sugiriendo una progresi\u00f3n m\u00e1s r\u00e1pida de la enfermedad, frente a cepas  nis\/r5 en los pacientes infectados por subtipo g, incluso en estad\u00edos avanzados de la enfermedad, lo que favorecer\u00eda la transmisi\u00f3n  y difusi\u00f3n de esta forma gen\u00e9tica. Se plante\u00f3 adem\u00e1s el estudio y seguimiento  de infecciones dobles por subtipo b y g con el fin de investigar la compartimentaci\u00f3n de las poblaciones recombinantes generadas. La obtenci\u00f3n de 6 aislados primarios y d e 17 secuencias del genoma completo del vih-1 de diferentes compartimentos, permiti\u00f3 definir la compartimentaci\u00f3n de formas recombinantes bg, definir los diferentes puntos de recombinaci\u00f3n existentes en las mismas y su papel en aspectos como son las caracterizaci\u00f3n biol\u00f3gica o la presencia de mutaciones de resistencia. La presencia de un patr\u00f3n de recombinaci\u00f3n en los genes gag, pol y nef, id\u00e9ntico durante 5 a\u00f1os de seguimiento y en diferentes compartimentos, nos hizo plantearnos la existencia d e determinadas posiciones en el genoma del vih-1 que facilitan la  persistencia de patrones de recombinaci\u00f3n. Con el fin de demostrar si existen regiones del genoma con mayor tendencia a la recombinaci\u00f3n se generaron 7 recombinantes in vitro y se com pararon con los seleccionados in vivo. La obtenci\u00f3n y an\u00e1lisis de 71 clones moleculares de dos fragmentos diferentes del genoma afianzan la idea de que en el gen pol, con mayor homolog\u00eda de su secuencia, se produce con mayor frecuencia el fen\u00f3meno de  la recombinaci\u00f3n.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Recombinaci\u00f3n gen\u00e9tica en vih-1: inducci\u00f3n de formas gen\u00e9ticas in vitro y su comparaci\u00f3n con las originadas in vivo.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Recombinaci\u00f3n gen\u00e9tica en vih-1: inducci\u00f3n de formas gen\u00e9ticas in vitro y su comparaci\u00f3n con las originadas in vivo. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mercedes Mu\u00f1oz Nieto-sandoval <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/09\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael Najera Morrondo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Prieto prieto <\/li>\n<li>esteban Domingo solans (vocal)<\/li>\n<li>ascensi\u00f3n Bernal zamora (vocal)<\/li>\n<li>Carlos j. Domingo fernandez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mercedes Mu\u00f1oz Nieto-sandoval Hasta el momento actual se han identificado 54 formas gen\u00e9ticas de vih-1, incluyendo 9 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[6958,139997,5645,3474,147332,6962],"class_list":["post-66906","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-ascension-bernal-zamora","tag-carlos-j-domingo-fernandez","tag-esteban-domingo-solans","tag-jose-prieto-prieto","tag-mercedes-munoz-nieto-sandoval","tag-rafael-najera-morrondo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/66906","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=66906"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/66906\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=66906"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=66906"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=66906"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}