{"id":66976,"date":"2018-03-09T22:55:19","date_gmt":"2018-03-09T22:55:19","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aplicaciones-terapeuticas-y-biotecnologicas-de-macrofagos-desactivados-por-suero-therapeutic-and-biotechnological-applications-of-serum-deactivated-macrophages\/"},"modified":"2018-03-09T22:55:19","modified_gmt":"2018-03-09T22:55:19","slug":"aplicaciones-terapeuticas-y-biotecnologicas-de-macrofagos-desactivados-por-suero-therapeutic-and-biotechnological-applications-of-serum-deactivated-macrophages","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/biologia-celular\/aplicaciones-terapeuticas-y-biotecnologicas-de-macrofagos-desactivados-por-suero-therapeutic-and-biotechnological-applications-of-serum-deactivated-macrophages\/","title":{"rendered":"Aplicaciones terap\u00e9uticas y biotecnol\u00f3gicas de macr\u00f3fagos desactivados por suero (therapeutic and biotechnological applications of serum-deactivated macrophages)"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Paloma Riquelme Madrona <\/strong><\/h2>\n<p>Los macr\u00f3fagos humanos derivados de monocitos adquieren propiedades espec\u00edficas cuando se cultivan con altas concentraciones de suero humano, incluyendo la capacidad supresora de linfocitos t y la expresi\u00f3n de algunas caracter\u00edsticas t\u00edpicas de c\u00e9lulas epiteliales. Los macr\u00f3fagos desactivados por suero humano se diferencian de otros tipos de macr\u00f3fago descritos en cuanto a ant\u00edgenos de superficie celular y actividad in vitro. Adem\u00e1s, este grupo de macr\u00f3fagos se deriva de un modo diferente, que depende de la inmunoglobulina presente en suero humano. un tipo de macr\u00f3fago desactivado por suero y estimulado con ifn-gamma, llamado macr\u00f3fago regulador o m reg, es capaz de inhibir la proliferaci\u00f3n de linfocitos t estimulados con pha y de polarizar linfocitos t hacia respuestas reguladoras. Dhrs9, una enzima retinol deshidrogenasa de la familia sdr, se ha identificado como un nuevo marcador de m regs.  en contra de publicaciones previas, se ha demostrado que otro tipo de macr\u00f3fago desactivado por suero, llamado pcmo, no es una c\u00e9lula progenitora multipotente. Sin embargo, derivados de pcmo expresan caracter\u00edsticas de hepatocitos y de c\u00e9lulas pancre\u00e1ticas como parte de un programa normal de diferenciaci\u00f3n macrof\u00e1gica, lo que significa que los neohepatocitos podr\u00edan ser usados en aplicaciones toxicol\u00f3gicas espec\u00edficas.  la caracterizaci\u00f3n fenot\u00edpica y funcional de m regs, pcmo, neohepatocitos y neoislotes permite clasificarlos en el contexto de estados de activaci\u00f3n de macr\u00f3fagos, y sugieren que los macr\u00f3fagos desactivados por suero humano presentan un fenotipo similar al de macr\u00f3fagos residentes en tejidos. Adem\u00e1s en este trabajo se han discutido las aplicaciones potenciales de macr\u00f3fagos desactivados por suero humano en terapias de reparaci\u00f3n de tejidos y de inducci\u00f3n de tolerancia inmunol\u00f3gica.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aplicaciones terap\u00e9uticas y biotecnol\u00f3gicas de macr\u00f3fagos desactivados por suero (therapeutic and biotechnological applications of serum-deactivated macrophages)<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aplicaciones terap\u00e9uticas y biotecnol\u00f3gicas de macr\u00f3fagos desactivados por suero (therapeutic and biotechnological applications of serum-deactivated macrophages) <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Paloma Riquelme Madrona <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pablo de olavide<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/09\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Bernat Soria Escoms<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: josep Mar\u00eda Griny\u00f3 boira <\/li>\n<li>edward kenneth Geissler (vocal)<\/li>\n<li>v\u00edctor S\u00e1nchez margalet (vocal)<\/li>\n<li>guillermo Anti\u00f1olo gil (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Paloma Riquelme Madrona Los macr\u00f3fagos humanos derivados de monocitos adquieren propiedades espec\u00edficas cuando se cultivan con altas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[849,17349,1737,37286,2953],"tags":[11639,147469,61427,48992,147468,38173],"class_list":["post-66976","post","type-post","status-publish","format-standard","hentry","category-biologia-celular","category-biotecnologia","category-inmunologia","category-pablo-de-olavide","category-trasplante-de-organos","tag-bernat-soria-escoms","tag-edward-kenneth-geissler","tag-guillermo-antinolo-gil","tag-josep-maria-grinyo-boira","tag-paloma-riquelme-madrona","tag-victor-sanchez-margalet"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/66976","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=66976"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/66976\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=66976"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=66976"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=66976"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}