{"id":67064,"date":"2018-03-09T22:55:27","date_gmt":"2018-03-09T22:55:27","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modificacion-de-los-biomarcadores-de-riesgo-cardivascular-y-del-perfil-proteomico-en-plasma-y-plaquetas-en-pacientes-con-hipertension-arteria-moderada-tratados-con-almesartan-mesoximil\/"},"modified":"2018-03-09T22:55:27","modified_gmt":"2018-03-09T22:55:27","slug":"modificacion-de-los-biomarcadores-de-riesgo-cardivascular-y-del-perfil-proteomico-en-plasma-y-plaquetas-en-pacientes-con-hipertension-arteria-moderada-tratados-con-almesartan-mesoximil","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modificacion-de-los-biomarcadores-de-riesgo-cardivascular-y-del-perfil-proteomico-en-plasma-y-plaquetas-en-pacientes-con-hipertension-arteria-moderada-tratados-con-almesartan-mesoximil\/","title":{"rendered":"Modificaci\u00f3n de los biomarcadores de riesgo cardivascular y del perfil prote\u00f3mico en plasma y plaquetas en pacientes con hipertensi\u00f3n arteria moderada tratados con almesartan mesoximil."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan  Mar\u00eda Gonzalez Del Castillo <\/strong><\/h2>\n<p>Null el olmesartan medoximil es un nuevo ara-ii cuyos efectos pleotr\u00f3picos no han sido a\u00fan aclarados. El objetivo de esta tesis es doble. En primer lugar observar los efectos del olmesartan medoximil sobre la tensi\u00f3n arterial y la funci\u00f3n renal en sujetos  con hipertensi\u00f3n arterial moderada y mal controlada. En estos pacientes los efectos pleotr\u00f3picos del olmesartan pueden ser m\u00e1s evidentes. Por otra parte, tratamos de determinar si el tratamiento con olmesartan medoximil pueda provocar efectos antiin flamatorios y modificar la expresi\u00f3n en el perfil de las prote\u00ednas de las plaquetas. Se incluyeron 13 pacientes con hipertensi\u00f3n arterial sist\u00f3lica moderada y mal controlada con una funci\u00f3n renal en estad\u00edo 2-3 de la clasificaci\u00f3n k\/doq i. Los pacien tes fueron tratados con olmesartan medoximil (24 mg\/d\u00eda) durante 6 meses. La tensi\u00f3n arterial sist\u00f3lica se redujo de forma significativa tras el tratamiento. La proteinuria y los niveles plasm\u00e1ticos de colesterol total y de la fracci\u00f3n ldl fueron igu almente menores tras el tratamiento con olmesartan. Los niveles circulantes en plasma de prote\u00ednas e isoformas de prote\u00ednas relacionadas con inflamaci\u00f3n no se modificaron tras el tratamiento. Despu\u00e9s del tratamiento con olmesartan medoximil, el nivel  de expresi\u00f3n de diferentes prote\u00ednas de las plaquetas, incluyendo las isoformas 3 y 4 de la tropomiosina, las isoformas 1, 2, 3, 4 y 5 de la serotransferrina, el inhibidor de la elastasa leucocitaria y la isoforma 1 de la prote\u00edna del canal intracel ular del cloro, fueron reducidas de forma significativa. Adem\u00e1s, la expresi\u00f3n de la isoforma 4 del precursor de la gelsolina se increment\u00f3 en las plaquetas despu\u00e9s del tratamiento con olmesart\u00e1n medoximil. En resumen, el tratamiento con olmesartan in duce cambios en la expresi\u00f3n de prote\u00ednas plaquetarias, lo cual puede estar relaccionado con alguna acci\u00f3n del f\u00e1rmaco a nivel del megacariocito.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modificaci\u00f3n de los biomarcadores de riesgo cardivascular y del perfil prote\u00f3mico en plasma y plaquetas en pacientes con hipertensi\u00f3n arteria moderada tratados con almesartan mesoximil.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modificaci\u00f3n de los biomarcadores de riesgo cardivascular y del perfil prote\u00f3mico en plasma y plaquetas en pacientes con hipertensi\u00f3n arteria moderada tratados con almesartan mesoximil. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan  Mar\u00eda Gonzalez Del Castillo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/09\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio L\u00f3pez Farr\u00e9<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Carlos Porres cubero <\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan Mar\u00eda Gonzalez Del Castillo Null el olmesartan medoximil es un nuevo ara-ii cuyos efectos pleotr\u00f3picos no [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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