{"id":67200,"date":"2018-03-09T22:55:34","date_gmt":"2018-03-09T22:55:34","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-de-nuevos-metodos-para-la-sa%c2%adntesis-en-disolucion-de-oligosacaridos-empleando-reactivos-soportados-y-qua%c2%admicamente-etiquetados\/"},"modified":"2018-03-09T22:55:34","modified_gmt":"2018-03-09T22:55:34","slug":"desarrollo-de-nuevos-metodos-para-la-sa%c2%adntesis-en-disolucion-de-oligosacaridos-empleando-reactivos-soportados-y-qua%c2%admicamente-etiquetados","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica-de-los-hidratos-de-carbono\/desarrollo-de-nuevos-metodos-para-la-sa%c2%adntesis-en-disolucion-de-oligosacaridos-empleando-reactivos-soportados-y-qua%c2%admicamente-etiquetados\/","title":{"rendered":"Desarrollo de nuevos m\u00e9todos para la s\u00edntesis en disoluci\u00f3n de oligosac\u00e1ridos empleando reactivos soportados y qu\u00edmicamente etiquetados"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Lourdes Encinas Prieto <\/strong><\/h2>\n<p>\u00edndice introducci\u00f3n \u00bb 1 1.1. Estrategias de glicosilaci\u00f3n en s\u00edntesis de oligosac\u00e1ridos y glicoconjugados ..\u00bb&#8230;&#8230; 3 1.2. Estrategias de purificaci\u00f3n en s\u00edntesis de oligosac\u00e1ridos y glicoconjugacdos .\u00bb.\u00bb&#8230;. 6 1.2.1. Etiquetado previo de los componentes de la reacci\u00f3n .\u00bb.\u00bb&#8230;,,,,,,. 8 1.2.1.1. Etiquetado de los substratos \u00ab8 1.2.1.1.1. Etiquetas qu\u00edmicas insolubles: s\u00edntesis en fase s\u00f3lida \u00ab8 1.2.1.1.2. Etiquetas qu\u00edmicas solubles \u00bb 9 a) etiquetas polim\u00e9ricas solubles &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.9 \u00bb etiquetas de oligoetilenglicol \u00ab&#8230;&#8230;.. 9 \u00bb copol\u00edmeros de n-iso-propilacrilamida \u00ab&#8230;&#8230;. 15 \u00bb pol\u00edmeros hiperramificados \u00ab&#8230;&#8230; 15 b) etiquetas polifluoradas. Fase fluorada \u00ab&#8230;&#8230;&#8230; 17 c) etiquetas lip\u00f3filas \u00ab&#8230;&#8230; 24 d) ligandos podando de oligoetilenglicol \u00ab&#8230;&#8230;&#8230; 30 e) etiquetas \u00abi\u00f3nicas \u00ab&#8230;&#8230;. 32 f) etiquetas coloreadas \u00ab35 1.2.1.2. Etiquetado de reactivos y catalizadores &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;. 36 1.2.1.2.1. Etiquetas qu\u00edmicas insolubles: reactivos y catalizadores soportados &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;36 1.2.1.2.1.1. Pol\u00edmeros org\u00e1nicos insolubles &#8230;&#8230;&#8230;&#8230;&#8230; 37 1.2.1.2.1.2. Soportes s\u00f3lidos inorg\u00e1nicos &#8230;&#8230;&#8230;&#8230;&#8230;&#8230; 44 1.2.1.2.2. Etiquetas qu\u00edmicas solubles 52 1.2.2. Etiquetado posterior de los componentes de la reacci\u00f3n &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;. 52 \u00edndice vi 1.2.2.1 etiquetado de reactivos y subproductos &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;. 52 1.2.2.1.1. Agentes secuestrantes de reactivos y subproductos &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;52 1.2.2.1.1.1. Etiquetas qu\u00edmicas insolubles &#8230;&#8230;&#8230;. 53 1.2.2.1.1.2. Etiquetas qu\u00edmicas solubles &#8230;&#8230;&#8230;&#8230;. 55 1.2.2.1.2. Agentes capacitadores del secuestro (\u00absequestration enabling reagents\u00bb) &#8230;&#8230;&#8230;.. 55 1.2.2.2. Etiquetado de productos: m\u00e9todo de captura y liberaci\u00f3n &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..59 1.2.2.2.1. Etiquetas qu\u00edmicas insolubles &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.. 60 1.2.2.2.2. Etiquetas qu\u00edmicas solubles &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.. 64 cap\u00edtulo i. Nuevos m\u00e9todos para la s\u00edntesis en disoluci\u00f3n de agentes dadores de glicosilo empleando reactivos soportados en pol\u00edmeros insolubles &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.67 2.1. Introducci\u00f3n &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;. 67 2.2. Resultados y discusi\u00f3n &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;. 71 2.2.1. S\u00edntesis de tricloroacetimidatos de glicosilo &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230; 71 2.2.2. S\u00edntesis de cloruros y bromuros de glicosilo &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.. 83 cap\u00edtulo ii. Desarrollo de reactivos soportados para la activaci\u00f3n en disoluci\u00f3n de hemiacetales de glicosilo y tioglic\u00f3sidos &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.95 3.1. Introducci\u00f3n &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;. 95 3.1.1. Activaci\u00f3n de hemiacetales de glicosilo &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230; 95 3.1.2. Activaci\u00f3n de tioglic\u00f3sidos &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.. 98 3.2. Resultados y discusi\u00f3n &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;. 104 3.2.1. S\u00edntesis de 1-(4&#8243;-hidroxibencenosulfinil)piperidina 38 &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.. 105 \u00edndice vii 3.2.2. S\u00edntesis del 4-(bencenosulfinil)fenol 41 &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230; 107 3.2.3. S\u00edntesis de los reactivos soportados en resina de poliestireno mediante una uni\u00f3n de tipo \u00e9ter &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.109 3.2.4. S\u00edntesis de los reactivos etiquetados con cadenas lip\u00f3filas &#8230;&#8230;&#8230;&#8230;&#8230; 113 3.2.5. Ensayos preliminares de glicosilaci\u00f3n utilizando los nuevos promotores preparados &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..113 3.2.6. Estudio del efecto del grupo protector del fenol 41 en la reacci\u00f3n de glicosilaci\u00f3n empleando modelos solubles &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;117 3.2.7. S\u00edntesis de los reactivos soportados en resina de poliestireno mediante una uni\u00f3n de tipo \u00e9ster &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.118 3.2.8. Reacciones de glicosilaci\u00f3n de hemiacetales de glicosilo utilizando el sulf\u00f3xido soportado 61 &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.123 3.2.9. Reacciones de glicosilaci\u00f3n de tioglic\u00f3sidos utilizando el sulf\u00f3xido 61 y la sulfinamida 63 soportados &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..128 cap\u00edtulo iii. Etiquetado lip\u00f3filo de carbohidratos &#8230;&#8230;&#8230;&#8230;.. 133 4.1. Introducci\u00f3n &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230; 133 4.2. Resultados y discusi\u00f3n &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;. 134 conclusiones &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.. 153 parte experimental &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;. 157 6.1. General &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230; 157 6.1.1. Disolventes y reactivos &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230; 157 a) disolventes &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;. 157 b) reactivos &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.. 157 6.1.2. T\u00e9cnicas y aparatos &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230; 158 a) procedimientos cromatogr\u00e1ficos &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.. 158 b) espectroscopia de resonancia magn\u00e9tica nuclear &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.. 158 \u00edndice viii c) espectrometr\u00eda de masas &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230; 159 d) puntos de fusi\u00f3n &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.. 159 e) an\u00e1lisis elemental &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;. 159 f) espectroscopia infrarroja con transformada de fourier &#8230;&#8230;&#8230;&#8230;&#8230;. 159 g) poderes \u00f3pticos rotatorios &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.. 160 6.2. Cap\u00edtulo i &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.. 160 6.2.1. S\u00edntesis de tricloroacetimidatos de glicosilo &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230; 160 6.2.2. S\u00edntesis de cloruros y bromuros de glicosilo &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.. 166 6.3. Cap\u00edtulo ii &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230; 175 6.4. Cap\u00edtulo iii &#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.. 226<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo de nuevos m\u00e9todos para la s\u00edntesis en disoluci\u00f3n de oligosac\u00e1ridos empleando reactivos soportados y qu\u00edmicamente etiquetados<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo de nuevos m\u00e9todos para la s\u00edntesis en disoluci\u00f3n de oligosac\u00e1ridos empleando reactivos soportados y qu\u00edmicamente etiquetados <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Lourdes Encinas Prieto <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/09\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Luis Chiara Romero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Garc\u00eda ruano <\/li>\n<li>carmen N\u00e1jera domingo (vocal)<\/li>\n<li>sergio Castillon miranda (vocal)<\/li>\n<li>rodolfo Lavilla grifols (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Lourdes Encinas Prieto \u00edndice introducci\u00f3n \u00bb 1 1.1. Estrategias de glicosilaci\u00f3n en s\u00edntesis de oligosac\u00e1ridos y glicoconjugados [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[3209],"tags":[19243,58768,5621,147895,85585,32735],"class_list":["post-67200","post","type-post","status-publish","format-standard","hentry","category-quimica-de-los-hidratos-de-carbono","tag-carmen-najera-domingo","tag-jose-luis-chiara-romero","tag-jose-luis-garcia-ruano","tag-lourdes-encinas-prieto","tag-rodolfo-lavilla-grifols","tag-sergio-castillon-miranda"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/67200","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=67200"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/67200\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=67200"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=67200"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=67200"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}