{"id":67286,"date":"2008-03-10T00:00:00","date_gmt":"2008-03-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-del-colesterol-mitocondrial-en-la-resistencia-del-carcinoma-hepatocelular-a-la-quimioterapia\/"},"modified":"2008-03-10T00:00:00","modified_gmt":"2008-03-10T00:00:00","slug":"papel-del-colesterol-mitocondrial-en-la-resistencia-del-carcinoma-hepatocelular-a-la-quimioterapia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/oncologia-clinica\/papel-del-colesterol-mitocondrial-en-la-resistencia-del-carcinoma-hepatocelular-a-la-quimioterapia\/","title":{"rendered":"Papel del colesterol mitocondrial en la resistencia del carcinoma hepatocelular a la quimioterapia"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan  Jos\u00e9 Montero Boronat <\/strong><\/h2>\n<p>Muchos tipos de tumores, entre ellos el carcinoma hepatocelular (chc), presentan elevados niveles de colesterol mitocondriales que podr\u00eda conferirles resistencia frente a distintos agentes quimioterap\u00e9uticos. En la tesis realizada por juan jos\u00e9 montero boronat, se muestra como una reducci\u00f3n de los niveles de colesterol en mitocondria aislada de l\u00edneas celulares de chc (reuber h35 o hepg2) las sensibiliza in vitro a est\u00edmulos como: radicales libres, atractil\u00f3sido, permeabilizaci\u00f3n por la prote\u00edna bax o calcio. A nivel celular, la disminuci\u00f3n de colesterol, ya sea por la utilizaci\u00f3n de estatinas (que inhiben el enzima limitante de la bios\u00edntesis de colesterol), del inhibidor de la escualeno sintasa ym-53601 o de sirna contra la prote\u00edna star (responsable de su transporte a la mitocondria) sensbiliza a las c\u00e9lulas tumorales frente a distintos quimioterap\u00e9uticos que act\u00faan en la mitocondria induciendo apoptosis: tri\u00f3xido de ars\u00e9nico, ionidamina, tapsigargina y doxorubicina. Tambi\u00e9n se observado como la administraci\u00f3n en un modelo xenographt in vivo, tanto de atorvastatina como de ym-53601, sensibiliza a (os tumores frente al f\u00e1rmaco doxorrubicina. Estos resultados abren la posibilidad de aplicar en terapia antitumoral inhibidores de la s\u00edntesis y el transporte de colesterol, combinados con quimioterap\u00e9uticos que act\u00faen en la mitocondria.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel del colesterol mitocondrial en la resistencia del carcinoma hepatocelular a la quimioterapia<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel del colesterol mitocondrial en la resistencia del carcinoma hepatocelular a la quimioterapia <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan  Jos\u00e9 Montero Boronat <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/10\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>chueca Fern\u00e1ndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: joan Caballeria rovira <\/li>\n<li>Mar\u00eda dolores L\u00f3pez tejero (vocal)<\/li>\n<li>cristina Mu\u00f1oz pinedo (vocal)<\/li>\n<li>albert Pol sorolla (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan Jos\u00e9 Montero Boronat Muchos tipos de tumores, entre ellos el carcinoma hepatocelular (chc), presentan elevados niveles [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,491,347],"tags":[86352,148061,126532,33878,148060,56039],"class_list":["post-67286","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-gastroenterologia","category-oncologia-clinica","tag-albert-pol-sorolla","tag-chueca-fernandez","tag-cristina-munoz-pinedo","tag-joan-caballeria-rovira","tag-juan-jose-montero-boronat","tag-maria-dolores-lopez-tejero"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/67286","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=67286"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/67286\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=67286"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=67286"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=67286"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}