{"id":67300,"date":"2008-06-10T00:00:00","date_gmt":"2008-06-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/alteracion-del-cromosoma-14-en-meningiomas-y-su-relacion-con-las-caractera%c2%adsticas-cla%c2%adnico-biologicas-de-la-enfermedad\/"},"modified":"2008-06-10T00:00:00","modified_gmt":"2008-06-10T00:00:00","slug":"alteracion-del-cromosoma-14-en-meningiomas-y-su-relacion-con-las-caractera%c2%adsticas-cla%c2%adnico-biologicas-de-la-enfermedad","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/neurocirugia\/alteracion-del-cromosoma-14-en-meningiomas-y-su-relacion-con-las-caractera%c2%adsticas-cla%c2%adnico-biologicas-de-la-enfermedad\/","title":{"rendered":"Alteraci\u00f3n del cromosoma 14 en meningiomas y su relaci\u00f3n con las caracter\u00edsticas cl\u00ednico-biol\u00f3gicas de la enfermedad"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Bel\u00e9n Espinosa Oquillas <\/strong><\/h2>\n<p>A pesar de que los meningiomas son tumores benignos del sistema nervioso central, se observan recidivas hasta en el 25% los pacientes. Nuestros resultados sugieren que en los meningiomas, la recidiva que sigue a una resecci\u00f3n quir\u00fargica completa, podr\u00eda deberse al recrecimiento del tumor primario, y raramente al desarrollo de un nuevo tumor independiente del meningioma inicial, al estar relacionados desde el punto de vista citogen\u00e9tico, los clones de c\u00e9lulas neopl\u00e1sicas detectados en el tumor primario y la recidiva. Por otra parte, los pacientes con meningiomas histol\u00f3gicamente benignos de tama\u00f1o > 5cm y que presentan coexistencia de monosom\u00eda 14 y del(1p36) en el clon tumoral ancestral, tienen una mayor probabilidad de sufrir una recidiva precoz, incluso despu\u00e9s de hab\u00e9rseles realizado una ex\u00e9resis completa del tumor, con lo que se deber\u00eda realizar un seguimiento m\u00e1s cercano de este subgrupo de pacientes con meningioma. Adem\u00e1s los pacientes varones respecto a las mujeres presentan diferentes patrones de alteraciones cromos\u00f3micas y perfiles de expresi\u00f3n g\u00e9nica, que podr\u00edan contribuir a explicar el comportamiento cl\u00ednico ligeramente diferente de este tipo de tumores en ambos sexos. En cuanto a las alteraciones del cromosoma 14, nuestros resultados indican que la mayor\u00eda de las anomal\u00edas gen\u00e9ticas que se detectan en el cromosoma 14 de las c\u00e9lulas tumorales de pacientes con meningioma, son de tipo num\u00e9rico, constituyendo las deleciones intersticiales a nivel de 14q31-q32 un hallazgo poco frecuente, tal y como lo demuestran los an\u00e1lisis de ifish y de cgh arrays. De todas las alteraciones detectadas en el cromosoma 14, s\u00f3lo la p\u00e9rdida total o monosom\u00eda 14 mostr\u00f3 un impacto significativo sobre la supervivencia libre de recidiva, asoci\u00e1ndose con un pron\u00f3stico adverso.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alteraci\u00f3n del cromosoma 14 en meningiomas y su relaci\u00f3n con las caracter\u00edsticas cl\u00ednico-biol\u00f3gicas de la enfermedad<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alteraci\u00f3n del cromosoma 14 en meningiomas y su relaci\u00f3n con las caracter\u00edsticas cl\u00ednico-biol\u00f3gicas de la enfermedad <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Bel\u00e9n Espinosa Oquillas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/10\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Alberto Orfao De Matos Correia E Vale<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: aurelio Ariza fern\u00e1ndez <\/li>\n<li>rosario Gil benso (vocal)<\/li>\n<li>Mar\u00eda concepci\u00f3n L\u00f3pez gin\u00e9s (vocal)<\/li>\n<li>Jes\u00fas Mar\u00eda Gon\u00ed\u00a7alves estella (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Bel\u00e9n Espinosa Oquillas A pesar de que los meningiomas son tumores benignos del sistema nervioso central, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9224,392,965,9386],"tags":[148082,14039,148084,25781,148083,132915],"class_list":["post-67300","post","type-post","status-publish","format-standard","hentry","category-citogenetica","category-neurocirugia","category-neuropatologia","category-salamanca","tag-ana-belen-espinosa-oquillas","tag-aurelio-ariza-fernandez","tag-jesus-maria-gonialves-estella","tag-jose-alberto-orfao-de-matos-correia-e-vale","tag-maria-concepcion-lopez-gines","tag-rosario-gil-benso"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/67300","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=67300"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/67300\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=67300"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=67300"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=67300"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}