{"id":67322,"date":"2008-08-10T00:00:00","date_gmt":"2008-08-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/polimorfismos-tipo-snp-en-el-trastorno-obsesivo-compulsivo\/"},"modified":"2008-08-10T00:00:00","modified_gmt":"2008-08-10T00:00:00","slug":"polimorfismos-tipo-snp-en-el-trastorno-obsesivo-compulsivo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/psiquiatria\/polimorfismos-tipo-snp-en-el-trastorno-obsesivo-compulsivo\/","title":{"rendered":"Polimorfismos tipo snp en el trastorno obsesivo-compulsivo"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Beatriz Rodr\u00edguez Salgado <\/strong><\/h2>\n<p>El trastorno obsesivo-compulsivo se caracteriza por pensamientos intrusos y comportamientos repetitivos. Estudios epidemiol\u00f3gicos recientes sit\u00faan la preValencia del trastorno en un 2-3% de la poblaci\u00f3n general, lo que lo convierte en una entidad no particularmente frecuente; sin embargo, la relevancia de su estudio radica en el hecho de que afecta a adultos j\u00f3venes, con una importante interferencia social y funcional. Por otra parte, el toc admite una aproximaci\u00f3n neurobiol\u00f3gica en la que se sustentan los modelos neuroanat\u00f3micos, los estudios de neuroimagen, las hip\u00f3tesis neuroqu\u00edmicas, los estudios de asociaci\u00f3n con patolog\u00edas org\u00e1nicas y las investigaciones gen\u00e9ticas.  \tel objetivo de este trabajo es el de realizar un an\u00e1lisis exploratorio de diferentes polimorfismos de un \u00fanico nucle\u00f3tido (snp) en una muestra de pacientes con diagn\u00f3stico de toc con el fin de encontrar nuevos genes candidatos con los que elaborar nuevas hip\u00f3tesis etiopatog\u00e9nicas. Este estudio examin\u00f3 883 snps pertenecientes a 312 genes de 9 v\u00edas neurofisiol\u00f3gicas, en una muestra compuesta por 92 pacientes con diagn\u00f3stico de toc, seg\u00fan criterios dsm-iv, y 374 controles sanos. \ttodos los snps se genotiparon con la plataforma snplex\u00c2\u00ae. Las frecuencias genot\u00edpicas se compararon entre pacientes y controles con un test de asociaci\u00f3n \u00c2\u00bf2 para el que situamos la p para la significaci\u00f3n estad\u00edstica en 0.001. \tcuatro nuevos snps se asociaron a la muestra de pacientes con toc para el umbral concebido: el gen de la preprotaquikinina i (rs1229434), el gen del receptor b2 de la bradikinina (rs8016905), el gen de la contactina 3 (rs13092046) y el gen del receptor 3 de la somatostatina (rs5756562).  \testos hallazgos apoyan las hip\u00f3tesis de que: 1) el toc tiene una base etiopatog\u00e9nica explicable, al menos en parte, por la dotaci\u00f3n gen\u00e9tica del individuo; 2)  algunas combinaciones de genes est\u00e1n en relaci\u00f3n con el hecho de padecer un toc; 3) algunos genes han podido no ser se\u00f1alados hasta la fecha; y 4) el an\u00e1lisis exploratorio de snps puede ser un m\u00e9todo \u00fatil para encontrar nuevos genes candidatos y elaborar nuevas hip\u00f3tesis etiopatog\u00e9nicas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Polimorfismos tipo snp en el trastorno obsesivo-compulsivo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Polimorfismos tipo snp en el trastorno obsesivo-compulsivo <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Beatriz Rodr\u00edguez Salgado <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/10\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jeronimo Saiz Ruiz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: tomas Palomo alvarez <\/li>\n<li>Jes\u00fas Valle fern\u00e1ndez (vocal)<\/li>\n<li>\u00e1ngela Ib\u00e1\u00f1ez cuadrado (vocal)<\/li>\n<li>Marta Torrens melich (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Beatriz Rodr\u00edguez Salgado El trastorno obsesivo-compulsivo se caracteriza por pensamientos intrusos y comportamientos repetitivos. Estudios epidemiol\u00f3gicos recientes [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17426,11771,1408],"tags":[97951,148121,15315,75578,33924,6196],"class_list":["post-67322","post","type-post","status-publish","format-standard","hentry","category-alcala","category-genetica-clinica","category-psiquiatria","tag-angela-ibanez-cuadrado","tag-beatriz-rodriguez-salgado","tag-jeronimo-saiz-ruiz","tag-jesus-valle-fernandez","tag-marta-torrens-melich","tag-tomas-palomo-alvarez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/67322","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=67322"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/67322\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=67322"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=67322"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=67322"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}